| Literature DB >> 33634055 |
Anisha Hegde1, Michelle R Denburg2, Dorey A Glenn3.
Abstract
Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.Entities:
Keywords: AKI; fibroblast growth factor 23; inflammation; klotho; mineral; parathyroid hormone; skeleton; vitamin D
Year: 2021 PMID: 33634055 PMCID: PMC7900149 DOI: 10.3389/fped.2020.635628
Source DB: PubMed Journal: Front Pediatr ISSN: 2296-2360 Impact factor: 3.418