Teresa Amaral1,2, Ioanna Tampouri1, Thomas Eigentler1, Ulrike Keim1, Bernhard Klumpp3, Vanessa Heinrich4, Daniel Zips4,5, Frank Paulsen4,5, Irina Gepfner-Tuma6,5, Marco Skardelly6,7,5, Marcos Tatagiba6,7,5, Ghazaleh Tabatabai6,5, Claus Garbe1, Andrea Forschner1. 1. Center for Dermatooncology, Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany. 2. Portuguese Air Force Health Direction, Paço do Lumiar, 1649-020, Lisbon, Portugal. 3. Department of Radiology, University Hospital Tuebingen, Tuebingen, Germany. 4. Department of Radiation Oncology, University Hospital Tuebingen, Tuebingen, Germany. 5. Centre for CNS Tumors at the Comprehensive Cancer Centre Tuebingen-Stuttgart, University Hospital Tuebingen, Tuebingen, Germany. 6. Interdisciplinary Division of Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tuebingen, Tuebingen, Germany. 7. Department of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany.
Abstract
AIM: Melanoma brain metastases (MBM) are associated with a dismal prognosis. Few clinical trials evaluated the impact of immunotherapy (IT) and targeted therapy (TT) alone or in combination with surgery and radiotherapy in this population. PATIENTS & METHODS: Retrospective analysis of data from 163 patients diagnosed with MBM between January 2014 and December 2016. Prognostic factors of overall survival were analyzed using Kaplan-Meier survival curves, classification and regression tree and multivariate Cox regression analysis. RESULTS: The median follow-up was 25 months; median overall survival (mOS) for all patients was 7 months. For patients receiving IT, the mOS was 13 months and 7 months for patients receiving TT or chemotherapy (CT). The mOS for patients treated with surgery/radiosurgery in combination with IT, TT and CT was 25, 14 and 11 months, respectively. CONCLUSION: New systemic therapies, especially IT, improve mOS in patients with MBM, particularly when combined with surgery/radiosurgery upfront.
AIM: Melanoma brain metastases (MBM) are associated with a dismal prognosis. Few clinical trials evaluated the impact of immunotherapy (IT) and targeted therapy (TT) alone or in combination with surgery and radiotherapy in this population. PATIENTS & METHODS: Retrospective analysis of data from 163 patients diagnosed with MBM between January 2014 and December 2016. Prognostic factors of overall survival were analyzed using Kaplan-Meier survival curves, classification and regression tree and multivariate Cox regression analysis. RESULTS: The median follow-up was 25 months; median overall survival (mOS) for all patients was 7 months. For patients receiving IT, the mOS was 13 months and 7 months for patients receiving TT or chemotherapy (CT). The mOS for patients treated with surgery/radiosurgery in combination with IT, TT and CT was 25, 14 and 11 months, respectively. CONCLUSION: New systemic therapies, especially IT, improve mOS in patients with MBM, particularly when combined with surgery/radiosurgery upfront.
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