| Literature DB >> 30605122 |
C O S Sorzano1, A Jiménez1, J Mota1, J L Vilas1, D Maluenda1, M Martínez1, E Ramírez-Aportela1, T Majtner1, J Segura1, R Sánchez-García1, Y Rancel1, L Del Caño1, P Conesa1, R Melero1, S Jonic2, J Vargas3, F Cazals4, Z Freyberg5, J Krieger5, I Bahar5, R Marabini6, J M Carazo1.
Abstract
Single-particle analysis by electron microscopy is a well established technique for analyzing the three-dimensional structures of biological macromolecules. Besides its ability to produce high-resolution structures, it also provides insights into the dynamic behavior of the structures by elucidating their conformational variability. Here, the different image-processing methods currently available to study continuous conformational changes are reviewed.Keywords: continuous heterogeneity; electron microscopy; image processing; normal-mode analysis; single-particle analysis
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Year: 2019 PMID： 30605122 PMCID： PMC6317454 DOI： 10.1107/S2053230X18015108
Source DB: PubMed Journal: Acta Crystallogr F Struct Biol Commun ISSN： 2053-230X Impact factor: 1.056