Caroline Bertoncini Silva1, Priscila Giacomo Fassini2, Leandra Náira Zambelli Ramalho3, Edemilson Cardoso da Conceição4, Aline José Coelho Moreira Zordan2, Daniela Carlos5, Vivian Marques Miguel Suen2. 1. Division of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil. bertoncinicaroline@gmail.com. 2. Division of Nutrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil. 3. Departament of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil. 4. Faculty of Pharmacy of Federal University of Goiás, Rua 240, esquina com 5ª Avenida, s/n, Setor Leste Universitário, Goiânia, Goiás, CEP 74605-170, Brazil. 5. Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
Abstract
PURPOSE: This experimental study investigated the effects of curcuma supplementation on weight gain, Body Adiposity Index, glucose and lipid profile, and liver and pancreas histology in C57BL/6 mice fed with a high-fat diet. METHODS: 40 animals were separated into four groups: standard diet (SD), standard diet plus curcuma (SD + C), high-fat diet (HFD), and high-fat diet plus curcuma (HFD + C). Curcuma dose was 8 mg/animal/day. Histological and biochemical analyses were performed at the end of the experimental period. RESULTS: Curcuma prevented weight gain, despite a higher food intake, and increased brown adipose tissue weight only in mice receiving standard diet. However, these changes were not observed in HFD + C group. The groups that received curcuma (SD + C and HFD + C) showed a pancreas with diffuse macro- and microgoticular steatosis. CONCLUSIONS: Curcuma supplementation did not prevent weight gain or improved glucose and lipid profile in mice receiving high-fat diet. Furthermore, there was evidence of possible curcuma toxicity in the pancreas of C57BL/6 mice. The implications of these findings on humans still need to be investigated.
PURPOSE: This experimental study investigated the effects of curcuma supplementation on weight gain, Body Adiposity Index, glucose and lipid profile, and liver and pancreas histology in C57BL/6 mice fed with a high-fat diet. METHODS: 40 animals were separated into four groups: standard diet (SD), standard diet plus curcuma (SD + C), high-fat diet (HFD), and high-fat diet plus curcuma (HFD + C). Curcuma dose was 8 mg/animal/day. Histological and biochemical analyses were performed at the end of the experimental period. RESULTS: Curcuma prevented weight gain, despite a higher food intake, and increased brown adipose tissue weight only in mice receiving standard diet. However, these changes were not observed in HFD + C group. The groups that received curcuma (SD + C and HFD + C) showed a pancreas with diffuse macro- and microgoticular steatosis. CONCLUSIONS: Curcuma supplementation did not prevent weight gain or improved glucose and lipid profile in mice receiving high-fat diet. Furthermore, there was evidence of possible curcuma toxicity in the pancreas of C57BL/6 mice. The implications of these findings on humans still need to be investigated.
Entities:
Keywords:
C57BL/6 mice; Curcuma; Phytotherapy; Toxicity; Weight gain
Authors: Katherine E Pinnick; Stephan C Collins; Constantine Londos; Dominique Gauguier; Anne Clark; Barbara A Fielding Journal: Obesity (Silver Spring) Date: 2008-01-17 Impact factor: 5.002
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