| Literature DB >> 30600998 |
Trong D Tran1, Brice A P Wilson1, Curtis J Henrich1,2, Louis M Staudt3, Lauren R H Krumpe1,2, Emily A Smith1,2, Jarrod King4, Karen L Wendt4, Alberto M Stchigel5, Andrew N Miller6, Robert H Cichewicz4, Barry R O'Keefe1,7, Kirk R Gustafson1.
Abstract
Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.Entities:
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Year: 2019 PMID： 30600998 PMCID： PMC7462088 DOI： 10.1021/acs.jnatprod.8b00871
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050