Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Natural Products as a Foundation for Drug Discovery.

Literature DB >> 31539923

Natural Products as a Foundation for Drug Discovery.

Abstract

Many natural products have been used as drugs for the treatment of diverse indications. Although most U.S. pharmaceutical companies have reduced or eliminated their in-house natural-product research over the years, new approaches for compound screening and chemical synthesis are resurrecting interest in exploring the therapeutic value of natural products. The aim of this commentary is to review emerging strategies and techniques that have made natural products a viable strategic choice for inclusion in drug discovery programs. Published 2019. U.S. Government. Published 2019. This article is a US Government work and is in the public domain in the USA.

Entities: Chemical

Keywords: drug discoveryzzm321990; natural products; screening

Mesh：

Substances：
Biological Products

Year: 2019 PMID： 31539923 PMCID： PMC7442317 DOI： 10.1002/cpph.67

Source DB: PubMed Journal: Curr Protoc Pharmacol ISSN： 1934-8282

147 in total

1. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina.

Authors: Mark Hildebrand; Laura E Waggoner; Haibin Liu; Sebastian Sudek; Scott Allen; Christine Anderson; David H Sherman; Margo Haygood
Journal: Chem Biol Date: 2004-11

2. Total synthesis and absolute configuration of the guaiane sesquiterpene englerin A.

Authors: Matthieu Willot; Lea Radtke; Daniel Könning; Roland Fröhlich; Viktoria H Gessner; Carsten Strohmann; Mathias Christmann
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

Review 3. Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms.

Authors: Laura V Flórez; Peter H W Biedermann; Tobias Engl; Martin Kaltenpoth
Journal: Nat Prod Rep Date: 2015-07 Impact factor: 13.423

4. Draft bill reignites U.S. debate over patenting human genes.

Authors: Kelly Servick
Journal: Science Date: 2019-06-14 Impact factor: 47.728

5. Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method.

Authors: Kan Li; Da-Song Yang; Xiao-Fei Gu; Bin Di
Journal: Fitoterapia Date: 2019-02-13 Impact factor: 2.882

6. Tiny crystals have big potential for determining structures of small molecules.

Authors: Alan Brown; Jon Clardy
Journal: Nature Date: 2018-12 Impact factor: 49.962

7. Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

Authors: Florent Olivon; Pierre-Marie Allard; Alexey Koval; Davide Righi; Gregory Genta-Jouve; Johan Neyts; Cécile Apel; Christophe Pannecouque; Louis-Félix Nothias; Xavier Cachet; Laurence Marcourt; Fanny Roussi; Vladimir L Katanaev; David Touboul; Jean-Luc Wolfender; Marc Litaudon
Journal: ACS Chem Biol Date: 2017-09-15 Impact factor: 5.100

8. A reinvestigation of Maprounea triterpenes.

Authors: J A Beutler; Y Kashman; M Tischler; J H Cardellina; G N Gray; M J Currens; M E Wall; M C Wani; M R Boyd
Journal: J Nat Prod Date: 1995-07 Impact factor: 4.050

9. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens.

Authors: Fei Xu; Behnam Nazari; Kyuho Moon; Leah B Bushin; Mohammad R Seyedsayamdost
Journal: J Am Chem Soc Date: 2017-06-29 Impact factor: 15.419

10. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

Authors: Zhongli Xu; Mikko Metsä-Ketelä; Christian Hertweck
Journal: J Biotechnol Date: 2008-11-13 Impact factor: 3.307

11 in total

Review 1. Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review.

Authors: Sze Yuen Lew; Michael Weng Lok Phang; Pit Shan Chong; Jaydeep Roy; Chi Him Poon; Wing Shan Yu; Lee Wei Lim; Kah Hui Wong
Journal: Pharmaceuticals (Basel) Date: 2022-06-19

2. Isolation of an Extract from the Soft Coral Symbiotic Microorganism Salinispora arenicola Exerting Cytoprotective and Anti-Aging Effects.

Authors: Xanthippi P Louka; Aimilia D Sklirou; Géraldine Le Goff; Philippe Lopes; Eleni-Dimitra Papanagnou; Maria S Manola; Yehuda Benayahu; Jamal Ouazzani; Ioannis P Trougakos
Journal: Curr Issues Mol Biol Date: 2021-12-22 Impact factor: 2.976

Review 3. Therapeutic roles of natural remedies in combating hereditary ataxia: A systematic review.

Authors: Michael Weng Lok Phang; Sze Yuen Lew; Ivy Chung; William Kiong-Seng Lim; Lee Wei Lim; Kah Hui Wong
Journal: Chin Med Date: 2021-01-28 Impact factor: 5.455

4. In silico approach for identifying natural lead molecules against SARS-COV-2.

Authors: Shiv Shankar Gupta; Ashwani Kumar; Ravi Shankar; Upendra Sharma
Journal: J Mol Graph Model Date: 2021-04-13 Impact factor: 2.518

5. Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay.

Authors: Guan-Yu Chen; Yi-Cheng Pan; Tung-Ying Wu; Tsung-You Yao; Wei-Jan Wang; Wan-Jou Shen; Azaj Ahmed; Shu-Ting Chan; Chih-Hsin Tang; Wei-Chien Huang; Mien-Chie Hung; Juan-Cheng Yang; Yang-Chang Wu
Journal: J Tradit Complement Med Date: 2021-09-16

Review 6. Screening S protein - ACE2 blockers from natural products: Strategies and advances in the discovery of potential inhibitors of COVID-19.

Authors: Le-le Ma; Hui-Min Liu; Xue-Mei Liu; Xiao-Yu Yuan; Chao Xu; Fang Wang; Jun-Zhi Lin; Run-Chun Xu; Ding-Kun Zhang
Journal: Eur J Med Chem Date: 2021-10-04 Impact factor: 6.514

7. Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function.

Authors: Neline Kriek; Sophie H Nock; Tanya Sage; Badrija Khalifa; Alexander P Bye; Joanne L Mitchell; Steven Thomson; Mark G McLaughlin; Sarah Jones; Jonathan M Gibbins; Amanda J Unsworth
Journal: Thromb Haemost Date: 2022-03-04 Impact factor: 6.681

8. Microbial sophorolipids inhibit colorectal tumour cell growth in vitro and restore haematocrit in Apc^min+/- mice.

Authors: Breedge Callaghan; Matthew S Twigg; Niki Baccile; Inge N A Van Bogaert; Roger Marchant; Christopher A Mitchell; Ibrahim M Banat
Journal: Appl Microbiol Biotechnol Date: 2022-08-15 Impact factor: 5.560

9. Aspartic Acid Isomerization Characterized by High Definition Mass Spectrometry Significantly Alters the Bioactivity of a Novel Toxin from Poecilotheria.

Authors: Stephen R Johnson; Hillary G Rikli
Journal: Toxins (Basel) Date: 2020-03-25 Impact factor: 4.546

10. Antibacterial, Antifungal, and Cytotoxic Activity of Excoecaria agallocha Leaf Extract.

Authors: Kuzhunellil Raghavanpillai Sabu; Sujith Sugathan; Akbar Idhayadhulla; Melat Woldemariam; Addis Aklilu; Gelila Biresaw; Behailu Tsegaye; Aseer Manilal
Journal: J Exp Pharmacol Date: 2022-01-14