| Literature DB >> 30600877 |
Yang Liu1,2, Wenyao Zhen1,2, Yinghui Wang1, Jianhua Liu3, Longhai Jin3, Tianqi Zhang3, Songtao Zhang1, Ying Zhao1,2, Shuyan Song1,2, Chengyu Li1, Junjie Zhu4, Yang Yang4, Hongjie Zhang1,2.
Abstract
The stringent reaction conditions for an effective Fenton reaction (pH range of 3-4) hinders its application in cancer therapy. Therefore, how to improve the efficiency of the Fenton reaction in a tumor site has been the main obstacle in chemodynamic therapy (CDT). Herein, we report biocompatible one-dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)- and photothermal (PT)-enhanced Fenton properties and excellent photothermal conversion efficiency (56.6 %) in the NIR II window, showing synergistic therapeutic properties. Additionally, the high photothermal conversion efficiency and excellent traverse relaxivity (277.79 mm-1 s-1 ) of the FP NRs means they are excellent photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agents. This is the first report on exploiting the response of metallic phosphides to NIR II laser (1064 nm) and ultrasound to improve the CDT effect with a high therapeutic effect and PA/MR imaging.Entities:
Keywords: Fenton reaction; NIR-II; iron; nanorods; theranostics
Year: 2019 PMID： 30600877 DOI： 10.1002/anie.201813702
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336