Hao-Hsien Lee1, Chong-Chi Chiu2, Jin-Jia Lin3, Jhi-Joung Wang4, King-Teh Lee5, Ding-Ping Sun6, Hon-Yi Shi7. 1. Department of Surgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan. Electronic address: hshi@kmu.edu.tw. 2. Department of Surgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Surgery, Chi Mei Medical Center, Yongkang, Tainan, Taiwan; Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan. 3. Department of Psychiatry, Chi-Mei Medical Center, Yongkang, Tainan, Taiwan; Department of Psychiatry, Chi-Mei Hospital, Liouying, Tainan, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 4. Department of Medical Research, Chi Mei Medical Center, Yongkang, Tainan, Taiwan. 5. Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, 100-Shih-Chun 1st Road, Kaohsiung 80708, Taiwan. 6. Department of Surgery, Chi Mei Medical Center, Yongkang, Tainan, Taiwan. 7. Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, 100-Shih-Chun 1st Road, Kaohsiung 80708, Taiwan; Department of Business Management, National Sun Yat-sen University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Abstract
OBJECTIVE: The impact of anxiety and depression symptoms (ADS) is often estimated in terms of clinical endpoints such as the risk of complications and probabilities of readmission and survival. The purpose of this study was to provide a benchmark for capturing the negative effects of ADS on quality of life after hepatocellular carcinoma (HCC) surgery and to provide an evidence base for future research and clinical interventions aimed at understanding and remediating these effects. METHODS: This prospective study analyzed 410 HCC patients at three tertiary academic hospitals. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Functional Assessment of Cancer Therapy- Hepatobiliary (FACT-H) were administered before HCC surgery and at 6 months, 1 year, and 2 years after HCC surgery. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of ADS. RESULTS: At baseline, 9.0% of the participants had anxiety symptom (BAI > 10), 17.1% had depression symptom (BDI > 13), and 7.1% had ADS. Throughout the study period, anxiety and depression (differences-in-differences value) had significant (P < 0.001) negative net effects on mean scores for all FACT-H dimensions, and the differences gradually increased over time. From baseline through all follow-up years, the two groups significantly (P < 0.001) differed in scores for all FACT-H dimensions, and the differences increased over time. CONCLUSIONS: For healthcare providers, this study highlights the need for continued monitoring for ADS in patients who have undergone hepatic resection and the need for timely and appropriate psychological care for these patients.
OBJECTIVE: The impact of anxiety and depression symptoms (ADS) is often estimated in terms of clinical endpoints such as the risk of complications and probabilities of readmission and survival. The purpose of this study was to provide a benchmark for capturing the negative effects of ADS on quality of life after hepatocellular carcinoma (HCC) surgery and to provide an evidence base for future research and clinical interventions aimed at understanding and remediating these effects. METHODS: This prospective study analyzed 410 HCC patients at three tertiary academic hospitals. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Functional Assessment of Cancer Therapy- Hepatobiliary (FACT-H) were administered before HCC surgery and at 6 months, 1 year, and 2 years after HCC surgery. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of ADS. RESULTS: At baseline, 9.0% of the participants had anxiety symptom (BAI > 10), 17.1% had depression symptom (BDI > 13), and 7.1% had ADS. Throughout the study period, anxiety and depression (differences-in-differences value) had significant (P < 0.001) negative net effects on mean scores for all FACT-H dimensions, and the differences gradually increased over time. From baseline through all follow-up years, the two groups significantly (P < 0.001) differed in scores for all FACT-H dimensions, and the differences increased over time. CONCLUSIONS: For healthcare providers, this study highlights the need for continued monitoring for ADS in patients who have undergone hepatic resection and the need for timely and appropriate psychological care for these patients.
Authors: Elena Kainz; Karin Stuff; Ursula Kahl; Christian Wiessner; Yuanyuan Yu; Franziska von Breunig; Rainer Nitzschke; Alexander Haese; Markus Graefen; Marlene Fischer Journal: Qual Life Res Date: 2022-01-27 Impact factor: 3.440
Authors: Ursula Kahl; Sarah Callsen; Stefanie Beck; Hans Pinnschmidt; Franziska von Breunig; Alexander Haese; Markus Graefen; Christian Zöllner; Marlene Fischer Journal: Health Qual Life Outcomes Date: 2021-02-25 Impact factor: 3.186