Vinícius de Melo Marques1, Camilla Sousa Santos2, Isabella Godinho Santiago3, Solomar Martins Marques1, Maria das Graças Nunes Brasil3, Talita Toledo Lima4, Paulo Sucasas Costa5. 1. Department of Pediatrics, School of Medicine, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. 2. Department of Pediatric Neurology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil. 3. Department of Pediatric Neurology, Hospital das Clínicas, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. 4. Department of Ophtalmology, Hospital das Clínicas, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. 5. Department of Pediatrics, School of Medicine, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. Electronic address: paulosucasas@ufg.br.
Abstract
BACKGROUND: In utero Zika virus infection resulted in many newborns with congenital defects; this public health issue was followed by unprecedented scientific productivity in this field. Many questions remain about congenital Zika virus infection and its maternal transmission, pathogenesis, clinical events, and the resulting neurological damage. There are few review articles that synthesize the current knowledge of congenital neurological complications as well as the gaps in the pediatric literature. OBJECTIVE: We review the full range of data on neurological complications in the newborns and infants born to Zika virus-infected women. METHODS: A research question (PCC: Population, newborns and infants of infected mothers; Concept, neurological outcomes at birth; Context, congenital Zika virus infection) was created to guide our review in searching several databases: PubMed, Lilacs, CINAHL, Cochrane Library, and OpenGrey literature. A total of 34 articles were included in the final review. RESULTS: Central nervous system calcifications, mainly at the cortical-subcortical junction, were the most prevalent neurological birth defects related to Zika infection (104/112, 92.9% from seven studies). Also, microcephaly occurred in 39.7% of all infected infants (1561/3931 patients in all the studies) and ventriculomegaly and/or hydrocephalus occurred in 63.1% (157/249 patients analyzed in 12 studies). A total of 10 articles detailed ocular findings, including macular lesions, focal pigment mottling of the retina, chorioretinal atrophy, optic nerve abnormalities, cataract, microphthalmia, and strabismus, among others. CONCLUSIONS: Neurological and related malformations are common lesions in individuals with congenital Zika syndrome. Long-term follow-up studies in this field are lacking.
BACKGROUND: In utero Zika virus infection resulted in many newborns with congenital defects; this public health issue was followed by unprecedented scientific productivity in this field. Many questions remain about congenital Zika virus infection and its maternal transmission, pathogenesis, clinical events, and the resulting neurological damage. There are few review articles that synthesize the current knowledge of congenital neurological complications as well as the gaps in the pediatric literature. OBJECTIVE: We review the full range of data on neurological complications in the newborns and infantsborn to Zika virus-infectedwomen. METHODS: A research question (PCC: Population, newborns and infants of infected mothers; Concept, neurological outcomes at birth; Context, congenital Zika virus infection) was created to guide our review in searching several databases: PubMed, Lilacs, CINAHL, Cochrane Library, and OpenGrey literature. A total of 34 articles were included in the final review. RESULTS:Central nervous system calcifications, mainly at the cortical-subcortical junction, were the most prevalent neurological birth defects related to Zika infection (104/112, 92.9% from seven studies). Also, microcephaly occurred in 39.7% of all infectedinfants (1561/3931 patients in all the studies) and ventriculomegaly and/or hydrocephalus occurred in 63.1% (157/249 patients analyzed in 12 studies). A total of 10 articles detailed ocular findings, including macular lesions, focal pigment mottling of the retina, chorioretinal atrophy, optic nerve abnormalities, cataract, microphthalmia, and strabismus, among others. CONCLUSIONS: Neurological and related malformations are common lesions in individuals with congenital Zika syndrome. Long-term follow-up studies in this field are lacking.
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