AIM: Our aim was to analyse 12-month outcomes of children who were prenatally exposed to the Zika virus and asymptomatic at birth. METHODS: This was an observational, exploratory study of infants exposed to the Zika virus during gestation and born between March 2016 and April 2017 without congenital Zika syndrome. They were followed until the age of 22 months. The outcome measure was neurodevelopment at 12 months of life, which was evaluated with the Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III). The scores were adjusted for maternal education and prematurity. RESULTS: A total of 96 infants were included in the study and 35.4% scored below the normal range in at least one Bayley-III domain. The majority (91.2%) of the infants with delayed scores presented with language delay, which was not associated with the gestational age at exposure. Receptive language was more affected by exposure than expressive language (27.0% vs 19.8%). There was a direct, and significant, association between the head circumference Z-score at birth and language delay. CONCLUSION: Language delay was associated with a smaller head circumference at birth in infants prenatally exposed to the Zika virus and born asymptomatic. This may indicate future learning difficulties.
AIM: Our aim was to analyse 12-month outcomes of children who were prenatally exposed to the Zika virus and asymptomatic at birth. METHODS: This was an observational, exploratory study of infants exposed to the Zika virus during gestation and born between March 2016 and April 2017 without congenital Zika syndrome. They were followed until the age of 22 months. The outcome measure was neurodevelopment at 12 months of life, which was evaluated with the Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III). The scores were adjusted for maternal education and prematurity. RESULTS: A total of 96 infants were included in the study and 35.4% scored below the normal range in at least one Bayley-III domain. The majority (91.2%) of the infants with delayed scores presented with language delay, which was not associated with the gestational age at exposure. Receptive language was more affected by exposure than expressive language (27.0% vs 19.8%). There was a direct, and significant, association between the head circumference Z-score at birth and language delay. CONCLUSION: Language delay was associated with a smaller head circumference at birth in infants prenatally exposed to the Zika virus and born asymptomatic. This may indicate future learning difficulties.
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Authors: Megan R Reynolds; Abbey M Jones; Emily E Petersen; Ellen H Lee; Marion E Rice; Andrea Bingham; Sascha R Ellington; Nicole Evert; Sarah Reagan-Steiner; Titilope Oduyebo; Catherine M Brown; Stacey Martin; Nina Ahmad; Julu Bhatnagar; Jennifer Macdonald; Carolyn Gould; Anne D Fine; Kara D Polen; Heather Lake-Burger; Christina L Hillard; Noemi Hall; Mahsa M Yazdy; Karnesha Slaughter; Jamie N Sommer; Alys Adamski; Meghan Raycraft; Shannon Fleck-Derderian; Jyoti Gupta; Kimberly Newsome; Madelyn Baez-Santiago; Sally Slavinski; Jennifer L White; Cynthia A Moore; Carrie K Shapiro-Mendoza; Lyle Petersen; Coleen Boyle; Denise J Jamieson; Dana Meaney-Delman; Margaret A Honein Journal: MMWR Morb Mortal Wkly Rep Date: 2017-04-07 Impact factor: 17.586
Authors: Jessica S Cranston; Sophia Finn Tiene; Karin Nielsen-Saines; Zilton Vasconcelos; Marcos V Pone; Sheila Pone; Andrea Zin; Tania Saad Salles; Jose Paulo Pereira; Dulce Orofino; Patricia Brasil; Tara Kerin; Kristina Adachi; Fernanda Mendes Soares; Andrea Dunshee de Abranches; Ana Carolina C da Costa; Maria Elisabeth Lopes Moreira Journal: JAMA Netw Open Date: 2020-07-01
Authors: Karin Nielsen-Saines; Patrícia Brasil; Tara Kerin; Zilton Vasconcelos; Claudia Raja Gabaglia; Luana Damasceno; Marcos Pone; Liege M Abreu de Carvalho; Sheila M Pone; Andrea A Zin; Irena Tsui; Tania Regina S Salles; Denise Cotrim da Cunha; Roozemerie Pereira Costa; Jociele Malacarne; Ana Beatriz Reis; Renata Hydee Hasue; Carolina Y P Aizawa; Fernanda F Genovesi; Christa Einspieler; Peter B Marschik; José Paulo Pereira; Stephanie L Gaw; Kristina Adachi; James D Cherry; Zhiheng Xu; Genhong Cheng; Maria Elisabeth Moreira Journal: Nat Med Date: 2019-07-08 Impact factor: 53.440
Authors: Pedro Massaroni Peçanha; Saint Clair Gomes Junior; Sheila Moura Pone; Marcos Vinicius da Silva Pone; Zilton Vasconcelos; Andrea Zin; Renata Hydee Hasue Vilibor; Roozemeria Pereira Costa; Maria Dalva Barbosa Baker Meio; Karin Nielsen-Saines; Patricia Brasil; Elizabeth Brickley; Maria Elisabeth Lopes Moreira Journal: PLoS One Date: 2020-02-28 Impact factor: 3.240
Authors: Lavínia Schuler-Faccini; Miguel Del Campo; Alfredo García-Alix; Liana O Ventura; Juliano André Boquett; Vanessa van der Linden; André Pessoa; Hélio van der Linden Júnior; Camila V Ventura; Mariana Carvalho Leal; Thayne Woycinck Kowalski; Lais Rodrigues Gerzson; Carla Skilhan de Almeida; Lucélia Santi; Walter O Beys-da-Silva; André Quincozes-Santos; Jorge A Guimarães; Patricia P Garcez; Julia do Amaral Gomes; Fernanda Sales Luiz Vianna; André Anjos da Silva; Lucas Rosa Fraga; Maria Teresa Vieira Sanseverino; Alysson R Muotri; Rafael Lopes da Rosa; Alberto Mantovani Abeche; Clairton Marcolongo-Pereira; Diogo O Souza Journal: Front Genet Date: 2022-03-08 Impact factor: 4.599
Authors: Luis Alfonso Díaz-Martínez; Mario Augusto Rojas; Luz Stella Pinilla-García; Carlos Hernán Becerra-Mojica; Luis Alfonso Pérez-Vera; Luz Ángela Gutiérrez-Sánchez; Gustavo Adolfo Contreras-García; Carol Gisela Rueda-Ordoñez; Luis Villar Journal: PLoS Negl Trop Dis Date: 2022-03-07