Roberta Manganaro1,2, Stella Marchetta1,2, Raluca Dulgheru1,2, Federica Ilardi1,2, Tadafumi Sugimoto1,3, Sébastien Robinet1,2, Sara Cimino1,2, Yun Yun Go1,2,4, Anne Bernard5, George Kacharava6, George D Athanassopoulos7, Daniele Barone8, Monica Baroni9, Nuno Cardim10, Andreas Hagendorff11, Krasimira Hristova12, Teresa López-Fernández13, Gonzalo de la Morena14, Bogdan A Popescu15, Martin Penicka16, Tolga Ozyigit17, Jose David Rodrigo Carbonero18, Nico van de Veire19, Ralph Stephan Von Bardeleben20, Dragos Vinereanu21, Jose Luis Zamorano22, Monica Rosca15, Andreea Calin15, Marie Moonen1,2, Julien Magne23, Bernard Cosyns24, Elena Galli25, Erwan Donal25, Scipione Carerj26, Concetta Zito26, Ciro Santoro27, Maurizio Galderisi27, Luigi P Badano28, Roberto M Lang29, Cecile Oury1,2, Patrizio Lancellotti1,2,30. 1. Departments of Cardiology, University of Liège Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liège, Belgium. 2. Department of Heart Valve Clinic, University of Liège Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liège, Belgium. 3. Clinical Laboratory, Mie University Hospital, Mie, 2-174 Edobashi, Tsu, Japan. 4. National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore. 5. Cardiology Department, CHU Tours, France et Université de Tours, Tours, France. 6. Cardiology Department, Tbilisi Institute of Medicine (TIM), 16 Tsintsadze, Tbilisi, Georgia. 7. Noninvasive Diagnostics Department, Onassis Cardiac Surgery Center, Athens, Greece. 8. Laboratory of Cardiovascular Ecography, Cardiology Department, S. Andrea Hospital, La Spezia, Italy. 9. Laboratorio Di Ecocardiografia Adulti, Fondazione Toscana "G.Monasterio" - Ospedale Del Cuore, Massa, Italy. 10. Echocardiography Laboratory, Hospital da Luz, Lisbon, Portugal. 11. Department of Cardiology, University of Leipzig, Leipzig, Germany. 12. Department of Noninvasive Functional Diagnostic and Imaging, University National Heart Hospital, Sofia, Bulgaria. 13. Cardiology Department, La Paz University Hospital, IdiPAz, Ciber CV, Paseo de la Castellana 261, Madrid, Spain. 14. Unidad de Imagen Cardiaca, Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, Spain. 15. Department of Cardiology, University of Medicine and Pharmacy "Carol Davila"-Euroecolab, Emergency Institute of Cardiovascular Diseases "Prof. Dr. C. C. Iliescu", Sos. Fundeni 258, Sector 2, Bucharest, Romania. 16. Cardiovascular Center Aalst, OLV-Clinic Moorselbaan 164, Aalst, Belgium. 17. VKV Amerikan Hastanesi, Kardiyoloji Bölümü, Istanbul, Turkey. 18. Laboratorio de Ecocardiografia Hospital de Cruces, Barakaldo, Spain. 19. Echocardiography Unit, AZ Maria Middelares, Gent, Belgium. 20. Medical Department Cardiology, Universitätsmedizin of the Johannes Gutenberg-University Mainz, Germany. 21. Department of Cardiology, Splaiul Independentei 169, Bucharest, Romania. 22. University Alcala, Hospital Ramón y Cajal, Madrid, Spain. 23. CHU Limoges, Hôpital Dupuytren, Service Cardiologie, Limoges, France. INSERM 1094, Faculté de Médecine de Limoges, Limoges, France. 24. CHVZ (Centrum voor Hart en Vaatziekten), Universitair ziekenhuis Brussel, ICMI (In Vivo Cellular and Molecular Imaging) Laboratory, Brussels, Belgium. 25. CIC-IT U 1414, CHU Rennes, Université Rennes 1, Service de Cardiologie, CHU Rennes, France. 26. Department of Clinical and Experimental Medicine, Section of Cardiology, University of Messina, 1, Via Consolare Valeria - Messina (IT), Italy. 27. Department of Advanced Biomedical Sciences, Federico II University Hospital Via S. Pansini 5, Naples, Italy. 28. Department of Cardiac, Thoracic and Vascular Sciences University of Padova, School of Medicine, Padova, Italy. 29. Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA. 30. Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy.
Abstract
AIMS: To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. METHODS AND RESULTS: A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. CONCLUSION: The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. METHODS AND RESULTS: A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. CONCLUSION: The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: A Hagendorff; A Helfen; R Brandt; E Altiok; O Breithardt; D Haghi; J Knierim; D Lavall; N Merke; C Sinning; S Stöbe; C Tschöpe; F Knebel; S Ewen Journal: Clin Res Cardiol Date: 2022-06-04 Impact factor: 5.460
Authors: Thuy T M Pham; Vien T Truong; Phuc N Vu; Truong X Tran; Nam N H Nguyen; Linh P T Nguyen; Hien N T Tu; Cassady Palmer; Justin T Tretter; Philip Levy; Wojciech Mazur; Vinh N Pham Journal: Pediatr Cardiol Date: 2021-07-30 Impact factor: 1.655
Authors: Felix Hedwig; Olena Nemchyna; Julia Stein; Christoph Knosalla; Nicolas Merke; Fabian Knebel; Andreas Hagendorff; Felix Schoenrath; Volkmar Falk; Jan Knierim Journal: Front Cardiovasc Med Date: 2021-06-18
Authors: Anum S Minhas; Nisha A Gilotra; Erin Goerlich; Thomas Metkus; Brian T Garibaldi; Garima Sharma; Nicole Bavaro; Susan Phillip; Erin D Michos; Allison G Hays Journal: Front Cardiovasc Med Date: 2021-06-14