| Literature DB >> 30583227 |
Eric Chun Shen Lee1, Safa Abdelgadir Mohamed Elhassan2, Grace Pei Ling Lim3, Weng Hong Kok4, Sze Wei Tan5, Ee Neng Leong6, Sean Hong Tan7, Elaine Wan Ling Chan8, Subrat Kumar Bhattamisra9, Ramkumar Rajendran10, Mayuren Candasamy11.
Abstract
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.Entities:
Keywords: Biomarkers; Circular RNAs; Development; Diseases; Organogenesis; Systems
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Year: 2018 PMID： 30583227 DOI： 10.1016/j.biopha.2018.12.052
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529