Li Wen1, Xiyao Liu1, Lan Wang2, Yangxi Zheng1, Jie Li1, Chao Tong3, Hongbo Qi4, Richard Saffery5, Philip Baker6. 1. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; International Collaborative Jointed Laboratory of Maternal and Fetal Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, China; Sate Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing 400016, China. 2. Department of Obstetrics, Chongqing Women and Children's Health Center, Chongqing 401147, China. 3. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; International Collaborative Jointed Laboratory of Maternal and Fetal Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, China; Sate Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing 400016, China. Electronic address: chaotongcqmu@163.com. 4. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; International Collaborative Jointed Laboratory of Maternal and Fetal Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, China; Sate Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing 400016, China. Electronic address: qihongbo728@163.com. 5. Cancer, Disease and Developmental Epigenetics, Murdoch Children's Research Institute, and Department of Paediatrics, University of Melbourne, Parkville Victoria 3052, Australia. 6. International Collaborative Jointed Laboratory of Maternal and Fetal Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, China; College of Life Sciences, University of Leicester, Leicester LE1 7RH, UK.
Abstract
PURPOSE: To investigate how second trimester gestational weight gain relates to perinatal outcomes in twin pregnancies of the LoTiS cohort in Chongqing, China. METHODS: A cohort study was conducted among women with dichorionic twin pregnancies; pregnancies that culminated in delivery at ≥20 gestational weeks were included in the analysis (n = 177). Data were collected through the Longitudinal Twin Study (LoTiS). The second trimester was divided into two periods: 12-20 and 21-28 gestational weeks. Correlations between maternal weight gain and perinatal outcomes were estimated using linear or logistic regression models; the crude OR and adjusted OR were calculated. RESULTS: The average total gestational weight gain for the whole pregnancy was 17.71 ± 4.98 kg and average gestational weight gains during 12-20 gestational weeks and 20-28 gestational weeks were 5.11 ± 1.81 kg and 5.84 ± 2.05 kg, respectively. Insufficient gestational weight gain was associated with higher risk of preterm birth (OR = 0.92, 95% CI 0.86-0.99) and spontaneous preterm birth (OR = 0.89, 95% CI 0.82-0.97). Reduced gestational weight gain during 12-20 gestational weeks was associated with higher risk of small for gestational age. Additionally, the mean birth weight of a twin pair increased by 45.78 g or 13.03 g when gestational weight gain during 12-20 weeks or total gestational weight gain increased by 1 kg. CONCLUSION: Maternal weight gain in the early second trimester was correlated with birth weight in dichorionic twins.
PURPOSE: To investigate how second trimester gestational weight gain relates to perinatal outcomes in twin pregnancies of the LoTiS cohort in Chongqing, China. METHODS: A cohort study was conducted among women with dichorionic twin pregnancies; pregnancies that culminated in delivery at ≥20 gestational weeks were included in the analysis (n = 177). Data were collected through the Longitudinal Twin Study (LoTiS). The second trimester was divided into two periods: 12-20 and 21-28 gestational weeks. Correlations between maternal weight gain and perinatal outcomes were estimated using linear or logistic regression models; the crude OR and adjusted OR were calculated. RESULTS: The average total gestational weight gain for the whole pregnancy was 17.71 ± 4.98 kg and average gestational weight gains during 12-20 gestational weeks and 20-28 gestational weeks were 5.11 ± 1.81 kg and 5.84 ± 2.05 kg, respectively. Insufficient gestational weight gain was associated with higher risk of preterm birth (OR = 0.92, 95% CI 0.86-0.99) and spontaneous preterm birth (OR = 0.89, 95% CI 0.82-0.97). Reduced gestational weight gain during 12-20 gestational weeks was associated with higher risk of small for gestational age. Additionally, the mean birth weight of a twin pair increased by 45.78 g or 13.03 g when gestational weight gain during 12-20 weeks or total gestational weight gain increased by 1 kg. CONCLUSION:Maternal weight gain in the early second trimester was correlated with birth weight in dichorionic twins.
Authors: Li Wen; Huisheng Ge; Juan Qiao; Lan Zhang; Xuyang Chen; Mark D Kilby; Ying Zhou; Jie Gan; Richard Saffery; Jianying Yan; Chao Tong; Hongbo Qi; Philip N Baker Journal: Nutr J Date: 2020-02-10 Impact factor: 3.271
Authors: Sisi Li; Yuhan Qiu; Xi Yuan; Qin Zhang; Mark D Kilby; Richard Saffery; Philip N Baker; Li Wen; Chao Tong; Hongbo Qi Journal: Front Pediatr Date: 2022-08-02 Impact factor: 3.569