Li Wen1,2,3, Huisheng Ge4, Juan Qiao1,2,3, Lan Zhang1,2,3, Xuyang Chen1,2,3, Mark D Kilby5,6, Ying Zhou1,2,3, Jie Gan1,2,3, Richard Saffery7, Jianying Yan8, Chao Tong9,10,11, Hongbo Qi12,13,14,15, Philip N Baker16. 1. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 2. International Collaborative Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China. 3. State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 4. Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China. 5. Fetal Medicine Centre, Birmingham Women's & Children's Foundation Trust, Birmingham, B15 2TG, UK. 6. Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, B15 2TT, UK. 7. Cancer, Disease and Developmental Epigenetics, Murdoch Children's Research Institute, and Department of Paediatrics University of Melbourne, Parkville, Victoria, 3052, Australia. 8. Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, 350001, Fujian, China. 9. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. chaotongcqmu@163.com. 10. International Collaborative Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China. chaotongcqmu@163.com. 11. State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. chaotongcqmu@163.com. 12. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. qihongbo728@163.com. 13. International Collaborative Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University, Chongqing, 400016, China. qihongbo728@163.com. 14. State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. qihongbo728@163.com. 15. Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, 350001, Fujian, China. qihongbo728@163.com. 16. College of Life Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Abstract
BACKGROUND: Gestational diabetes mellitus (GDM) is correlated with an increased risk of adverse perinatal outcomes for both the mother and offspring. Previous research has reported correlations between maternal dietary patterns and GDM, but such evidence for twin pregnancies is lacking. This study aimed to identify maternal dietary patterns in the second trimester and investigate their relationships with the risk of GDM among women who were pregnant with twins in China. METHODS: A longitudinal twin pregnancies birth cohort study of women who were pregnant with twins in China was conducted. Maternal dietary intake in the second trimester was recorded by using a food frequency questionnaire prior to the diagnosis of GDM among participants from the prospective twin pregnancies birth cohort in Chongqing City. GDM was diagnosed with a 75 g 2-h oral glucose tolerance test at 23-26 weeks of gestation. Dietary patterns were identified by principal components analysis, and the correlations between dietary pattern and GDM were examined using multivariable logistic regression analyses. RESULTS: Of the 324 participants, 101 (31.2%) were diagnosed with GDM. Four dietary patterns were identified: a vegetable-based pattern, a poultry-and-fruit-based pattern, a sweet-based pattern and a plant-protein-based pattern. Multivariate analysis showed that none of the dietary patterns were correlated with the risk of GDM among women who were pregnant with twins, but the sweet-based dietary pattern, which was associated with a higher GDM risk for quartile 4 versus quartile 1 (OR 2.69; 95% CI: 1.09, 6.66) among non-overweight women (prepregnancy BMI < 24.0). CONCLUSION: Dietary patterns were not correlated with later GDM risk among women who were pregnant with twins in western China, whereas a high intake of sweets was associated with a higher risk for GDM among women who were not overweight prior to pregnancy. TRIAL REGISTRATION: ChiCTR-OOC-16008203. Retrospectively registered on 1 April 2016.
BACKGROUND:Gestational diabetes mellitus (GDM) is correlated with an increased risk of adverse perinatal outcomes for both the mother and offspring. Previous research has reported correlations between maternal dietary patterns and GDM, but such evidence for twin pregnancies is lacking. This study aimed to identify maternal dietary patterns in the second trimester and investigate their relationships with the risk of GDM among women who were pregnant with twins in China. METHODS: A longitudinal twin pregnancies birth cohort study of women who were pregnant with twins in China was conducted. Maternal dietary intake in the second trimester was recorded by using a food frequency questionnaire prior to the diagnosis of GDM among participants from the prospective twin pregnancies birth cohort in Chongqing City. GDM was diagnosed with a 75 g 2-h oral glucose tolerance test at 23-26 weeks of gestation. Dietary patterns were identified by principal components analysis, and the correlations between dietary pattern and GDM were examined using multivariable logistic regression analyses. RESULTS: Of the 324 participants, 101 (31.2%) were diagnosed with GDM. Four dietary patterns were identified: a vegetable-based pattern, a poultry-and-fruit-based pattern, a sweet-based pattern and a plant-protein-based pattern. Multivariate analysis showed that none of the dietary patterns were correlated with the risk of GDM among women who were pregnant with twins, but the sweet-based dietary pattern, which was associated with a higher GDM risk for quartile 4 versus quartile 1 (OR 2.69; 95% CI: 1.09, 6.66) among non-overweight women (prepregnancy BMI < 24.0). CONCLUSION: Dietary patterns were not correlated with later GDM risk among women who were pregnant with twins in western China, whereas a high intake of sweets was associated with a higher risk for GDM among women who were not overweight prior to pregnancy. TRIAL REGISTRATION: ChiCTR-OOC-16008203. Retrospectively registered on 1 April 2016.
Authors: B Karamanos; A Thanopoulou; E Anastasiou; S Assaad-Khalil; N Albache; M Bachaoui; C B Slama; H El Ghomari; A Jotic; N Lalic; A Lapolla; C Saab; M Marre; J Vassallo; C Savona-Ventura Journal: Eur J Clin Nutr Date: 2013-10-02 Impact factor: 4.016
Authors: Jonathan K L Mak; Ngoc Minh Pham; Andy H Lee; Li Tang; Xiong-Fei Pan; Colin W Binns; Xin Sun Journal: Nutr J Date: 2018-11-20 Impact factor: 3.271