Taraneh Gharib Nazem1, Lucky Sekhon2, Joseph A Lee3, Jessica Overbey4, Stephanie Pan4, Marlena Duke3, Christine Briton-Jones3, Michael Whitehouse3, Alan B Copperman2, Daniel E Stein5. 1. Reproductive Medicine Associates of New York, 635 Madison Avenue, 10th Floor, New York, NY 10022, USA; Department of Obstetrics and Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion, 9th Floor, 1176 Fifth Avenue, New York, NY 10029, USA. Electronic address: tnazem@rmany.com. 2. Reproductive Medicine Associates of New York, 635 Madison Avenue, 10th Floor, New York, NY 10022, USA; Department of Obstetrics and Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Klingenstein Pavilion, 9th Floor, 1176 Fifth Avenue, New York, NY 10029, USA. 3. Reproductive Medicine Associates of New York, 635 Madison Avenue, 10th Floor, New York, NY 10022, USA. 4. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5. Reproductive Medicine Associates of New York, 635 Madison Avenue, 10th Floor, New York, NY 10022, USA; Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai West, 1000 10th Avenue, 10th Floor, New York, NY 10019, USA.
Abstract
RESEARCH QUESTION: Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates? DESIGN: Retrospective cohort study including a total of 2236 embryos from 1629 patients who underwent single euploid FET between 2012 and 2017. RESULTS: Embryos with an ICM grade of A compared with C had a higher OP/LB rate (55.6% versus 32.3%, P < 0.001). Blastocysts with a TE grade of A or B compared with C had a higher likelihood of OP/LB (A versus C: odds ratio [OR] 1.6, 99% confidence interval [CI] 1.1-2.3, B versus C: OR 1.5, 99% CI 1.1-2.1), and blastocysts with a developmental stage of 4 or 5 compared with 6 had higher odds of OP/LB (4 versus 6: OR 1.6, 99% CI 1.2-2.2, 5 versus 6: OR 1.6, 99% CI 1.2-2.3). CONCLUSIONS: Among euploid embryos, ICM morphology is the best predictor of sustained implantation; however, a composite score may provide additional guidance. While there is a known benefit in genomic screening prior to embryo selection, morphology provides individualized, prognostic information about implantation potential.
RESEARCH QUESTION: Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates? DESIGN: Retrospective cohort study including a total of 2236 embryos from 1629 patients who underwent single euploid FET between 2012 and 2017. RESULTS: Embryos with an ICM grade of A compared with C had a higher OP/LB rate (55.6% versus 32.3%, P < 0.001). Blastocysts with a TE grade of A or B compared with C had a higher likelihood of OP/LB (A versus C: odds ratio [OR] 1.6, 99% confidence interval [CI] 1.1-2.3, B versus C: OR 1.5, 99% CI 1.1-2.1), and blastocysts with a developmental stage of 4 or 5 compared with 6 had higher odds of OP/LB (4 versus 6: OR 1.6, 99% CI 1.2-2.2, 5 versus 6: OR 1.6, 99% CI 1.2-2.3). CONCLUSIONS: Among euploid embryos, ICM morphology is the best predictor of sustained implantation; however, a composite score may provide additional guidance. While there is a known benefit in genomic screening prior to embryo selection, morphology provides individualized, prognostic information about implantation potential.
Authors: Andrea Abdala; Ibrahim Elkhatib; Aşina Bayram; Ana Arnanz; Ahmed El-Damen; Laura Melado; Barbara Lawrenz; Human M Fatemi; Neelke De Munck Journal: J Assist Reprod Genet Date: 2022-01-22 Impact factor: 3.412
Authors: Jenna Friedenthal; Carlos Hernandez-Nieto; Rose Marie Roth; Richard Slifkin; Dmitry Gounko; Joseph A Lee; Taraneh Nazem; Christine Briton-Jones; Alan Copperman Journal: J Assist Reprod Genet Date: 2021-05-01 Impact factor: 3.357