Massimiliano Orri1, Cedric Galera2, Gustavo Turecki3, Michel Boivin4, Richard E Tremblay5, Marie-Claude Geoffroy6, Sylvana M Côté7. 1. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada; Bordeaux Population Health Research Centre, INSERM U1219, University of Bordeaux, France. 2. Bordeaux Population Health Research Centre, INSERM U1219, University of Bordeaux, France; Charles Perrens Hospital, University of Bordeaux, France. 3. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada. 4. School of Psychology, Laval University, Québec City, Québec, Canada, and the Institute of Genetic, Neurobiological, and Social Foundations of Child Development at Tomsk State University, Russian Federation. 5. School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland, and the University of Montréal, Québec, Canada. 6. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada. Electronic address: marie-claude.geoffroy@mcgill.ca. 7. Bordeaux Population Health Research Centre, INSERM U1219, University of Bordeaux, France; University of Montreal, Québec, Canada.
Abstract
OBJECTIVE: Childhood irritability predicts suicidal ideation/attempt (suicidality), but it is unclear whether irritability is an independent and direct risk factor for suicidality or a marker of intermediate mental health symptoms associated with suicidality. This study aimed to identify developmental patterns of childhood irritability and to test whether childhood irritability is directly associated with suicidality or indirectly associated with intermediate mental health symptoms. METHOD: One thousand three hundred ninety-three participants from the Québec Longitudinal Study of Child Development were followed from birth to 17 years. Teachers assessed irritability yearly (at 6-12 years) and children self-reported intermediate mental health symptoms (depression, anxiety, disruptiveness, and hyperactivity-impulsivity; at 13 years) and suicidality (at 15 and 17 years). RESULTS: Four irritability trajectories were identified: low (74.7%), rising (13.0%), declining (7.4%), and persistent (5.0%). Children following a rising irritability trajectory (versus a low trajectory) were at higher suicidality risk. A large proportion of this association was direct (odds ratio 2.11, 95% CI 1.30-3.43) and a small proportion was indirect by depressive symptoms (accounting for 23% of the association; odds ratio 1.17, 95% CI 1.03-1.34). Children on a persistent irritability trajectory (versus a low trajectory) were at higher risk of suicidality and this association was uniquely indirect by depressive symptoms (accounting for 73% of the association; odds ratio 1.51, 95% CI 1.16-1.97). The declining trajectory was not related to suicidality; no association with anxiety, disruptiveness, and hyperactivity-impulsivity was found. CONCLUSION: Rising irritability across childhood represents a direct risk for suicidality. Persistent irritability appears to be a distal marker of suicidality acting through more proximal depressive symptoms.
OBJECTIVE: Childhood irritability predicts suicidal ideation/attempt (suicidality), but it is unclear whether irritability is an independent and direct risk factor for suicidality or a marker of intermediate mental health symptoms associated with suicidality. This study aimed to identify developmental patterns of childhood irritability and to test whether childhood irritability is directly associated with suicidality or indirectly associated with intermediate mental health symptoms. METHOD: One thousand three hundred ninety-three participants from the Québec Longitudinal Study of Child Development were followed from birth to 17 years. Teachers assessed irritability yearly (at 6-12 years) and children self-reported intermediate mental health symptoms (depression, anxiety, disruptiveness, and hyperactivity-impulsivity; at 13 years) and suicidality (at 15 and 17 years). RESULTS: Four irritability trajectories were identified: low (74.7%), rising (13.0%), declining (7.4%), and persistent (5.0%). Children following a rising irritability trajectory (versus a low trajectory) were at higher suicidality risk. A large proportion of this association was direct (odds ratio 2.11, 95% CI 1.30-3.43) and a small proportion was indirect by depressive symptoms (accounting for 23% of the association; odds ratio 1.17, 95% CI 1.03-1.34). Children on a persistent irritability trajectory (versus a low trajectory) were at higher risk of suicidality and this association was uniquely indirect by depressive symptoms (accounting for 73% of the association; odds ratio 1.51, 95% CI 1.16-1.97). The declining trajectory was not related to suicidality; no association with anxiety, disruptiveness, and hyperactivity-impulsivity was found. CONCLUSION: Rising irritability across childhood represents a direct risk for suicidality. Persistent irritability appears to be a distal marker of suicidality acting through more proximal depressive symptoms.
Authors: Alberto Forte; Massimiliano Orri; Cédric Galera; Maurizio Pompili; Gustavo Turecki; Michel Boivin; Richard E Tremblay; Sylvana M Côté Journal: Eur Child Adolesc Psychiatry Date: 2019-04-25 Impact factor: 4.785
Authors: Massimiliano Orri; Michel Boivin; Chelsea Chen; Marilyn N Ahun; Marie-Claude Geoffroy; Isabelle Ouellet-Morin; Richard E Tremblay; Sylvana M Côté Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2020-11-13 Impact factor: 4.328
Authors: Reut Naim; Katharina Kircanski; Andrea Gold; Ramaris E German; Mollie Davis; Samantha Perlstein; Michal Clayton; Olga Revzina; Melissa A Brotman Journal: BMJ Open Date: 2021-03-10 Impact factor: 2.692
Authors: Emma Chad-Friedman; Maria M Galano; Edward P Lemay; Thomas M Olino; Daniel N Klein; Lea R Dougherty Journal: Dev Psychopathol Date: 2021-12-27
Authors: Marie C Navarro; Isabelle Ouellet-Morin; Marie-Claude Geoffroy; Michel Boivin; Richard E Tremblay; Sylvana M Côté; Massimiliano Orri Journal: JAMA Netw Open Date: 2021-03-01