PURPOSE: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). METHODS: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm × 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. RESULTS: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0-0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2-3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0-14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. CONCLUSION: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR.
PURPOSE: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). METHODS: Sixty-eight diabeticpatients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm × 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. RESULTS: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0-0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2-3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0-14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. CONCLUSION: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR.
Authors: Akihiro Ishibazawa; Lucas R De Pretto; A Yasin Alibhai; Eric M Moult; Malvika Arya; Osama Sorour; Nihaal Mehta; Caroline R Baumal; Andre J Witkin; Akitoshi Yoshida; Jay S Duker; James G Fujimoto; Nadia K Waheed Journal: Invest Ophthalmol Vis Sci Date: 2019-10-01 Impact factor: 4.799
Authors: Jesse J Jung; Daryle Jason G Yu; Anne Zeng; Michael H Chen; Yue Shi; Marco Nassisi; Kenneth M Marion; Srinivas R Sadda; Quan V Hoang Journal: Ophthalmol Retina Date: 2020-05-07
Authors: Lucas R De Pretto; Eric M Moult; A Yasin Alibhai; Oscar M Carrasco-Zevallos; Siyu Chen; ByungKun Lee; Andre J Witkin; Caroline R Baumal; Elias Reichel; Anderson Zanardi de Freitas; Jay S Duker; Nadia K Waheed; James G Fujimoto Journal: Sci Rep Date: 2019-06-24 Impact factor: 4.379
Authors: Ying Cui; Ying Zhu; Jay C Wang; Yifan Lu; Rebecca Zeng; Raviv Katz; David M Wu; Demetrios G Vavvas; Deeba Husain; Joan W Miller; Leo A Kim; John B Miller Journal: Transl Vis Sci Technol Date: 2019-11-15 Impact factor: 3.283
Authors: Kai Yuan Tey; Kelvin Teo; Anna C S Tan; Kavya Devarajan; Bingyao Tan; Jacqueline Tan; Leopold Schmetterer; Marcus Ang Journal: Eye Vis (Lond) Date: 2019-11-18