Karandeep Singh1, Amy L Tin2, Rodney L Dunn3, Tae Kim3, Andrew J Vickers2. 1. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; School of Information, University of Michigan, Ann Arbor, MI, USA; Michigan Urological Surgery Improvement Collaborative, Ann Arbor, MI, USA. Electronic address: kdpsingh@umich.edu. 2. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3. Michigan Urological Surgery Improvement Collaborative, Ann Arbor, MI, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA.
Abstract
BACKGROUND: Patient-reported outcome measures (PROMs) have become widely adopted in the care of patients with prostate cancer, but there is no validated crosswalk between two commonly used instruments, the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) and the Memorial Sloan Kettering (MSK) instrument, which consists of the International Index of Erectile Function-6 (IIEF-6) questionnaire and the MSK radical prostatectomy urinary outcome scale. OBJECTIVE: To develop and validate bidirectional crosswalks between the sexual and urinary domains (single domain in MSK, separate incontinence and irritative/obstructive domains in EPIC-26) of the MSK and EPIC-26 instruments. DESIGN, SETTING, AND PARTICIPANTS: Radical prostatectomy (RP) patients completing instruments at MSK and Michigan Urological Surgery Improvement Collaborative (MUSIC) between January and May of 2017 were invited to enroll. Stratified random sampling (by institution, MSK urinary function score, and MSK erectile function score) was used to divide patient data into training and test sets. Models were developed to predict the domain score for each instrument using the other's item responses and domain scores. Performance was evaluated using capped root-mean-squared error and accuracy at established thresholds. RESULTS AND LIMITATIONS: We received 517 instruments at MSK and 1033 within MUSIC, which were assigned to training (825), post-RP test (412), and pre-RP test (313) sets. We found the crosswalks to have low error and high accuracy. Although the crosswalks are more accurate if responses to each item are known, it is possible to convert between instruments on the basis of a total domain score. CONCLUSIONS: The crosswalks are a valid way to convert between sexual and urinary domains of the MSK and EPIC-26 instruments. PATIENT SUMMARY: We developed and validated a set of formulas that allow conversion of sexual and urinary function scores between the Memorial Sloan Kettering and Expanded Prostate Cancer Index Composite Short Form patient-reported outcome questionnaires. These crosswalks allow seamless transition between the two questionnaires.
BACKGROUND:Patient-reported outcome measures (PROMs) have become widely adopted in the care of patients with prostate cancer, but there is no validated crosswalk between two commonly used instruments, the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) and the Memorial Sloan Kettering (MSK) instrument, which consists of the International Index of Erectile Function-6 (IIEF-6) questionnaire and the MSK radical prostatectomy urinary outcome scale. OBJECTIVE: To develop and validate bidirectional crosswalks between the sexual and urinary domains (single domain in MSK, separate incontinence and irritative/obstructive domains in EPIC-26) of the MSK and EPIC-26 instruments. DESIGN, SETTING, AND PARTICIPANTS: Radical prostatectomy (RP) patients completing instruments at MSK and Michigan Urological Surgery Improvement Collaborative (MUSIC) between January and May of 2017 were invited to enroll. Stratified random sampling (by institution, MSK urinary function score, and MSK erectile function score) was used to divide patient data into training and test sets. Models were developed to predict the domain score for each instrument using the other's item responses and domain scores. Performance was evaluated using capped root-mean-squared error and accuracy at established thresholds. RESULTS AND LIMITATIONS: We received 517 instruments at MSK and 1033 within MUSIC, which were assigned to training (825), post-RP test (412), and pre-RP test (313) sets. We found the crosswalks to have low error and high accuracy. Although the crosswalks are more accurate if responses to each item are known, it is possible to convert between instruments on the basis of a total domain score. CONCLUSIONS: The crosswalks are a valid way to convert between sexual and urinary domains of the MSK and EPIC-26 instruments. PATIENT SUMMARY: We developed and validated a set of formulas that allow conversion of sexual and urinary function scores between the Memorial Sloan Kettering and Expanded Prostate Cancer Index Composite Short Form patient-reported outcome questionnaires. These crosswalks allow seamless transition between the two questionnaires.
Authors: Montse Ferrer; Olatz Garin; Joan Pera; Josep Maria Prats; Joan Mendivil; Jordi Alonso; Belén De Paula; Ismael Herruzo; Asunción Hervas; Víctor Macias; Alfonso Mariño; María José Ortiz; Sergio Pastor; Javier Ponce De León; Gemma Sancho Journal: Med Clin (Barc) Date: 2009-02-04 Impact factor: 1.725
Authors: Justin K Lee; Melissa Assel; Alan E Thong; Daniel D Sjoberg; John P Mulhall; Jaspreet Sandhu; Andrew J Vickers; Behfar Ehdaie Journal: Eur Urol Date: 2015-08-17 Impact factor: 20.096
Authors: Emily A Vertosick; Andrew J Vickers; Janet E Cowan; Jeanette M Broering; Peter R Carroll; Matthew R Cooperberg Journal: J Urol Date: 2017-03-22 Impact factor: 7.450
Authors: Alicia K Morgans; Annelotte C M van Bommel; Caleb Stowell; Janet L Abrahm; Ethan Basch; Justin E Bekelman; Donna L Berry; Alberto Bossi; Ian D Davis; Theo M de Reijke; Louis J Denis; Sue M Evans; Neil E Fleshner; Daniel J George; Jim Kiefert; Daniel W Lin; Andrew G Matthew; Ray McDermott; Heather Payne; Ian A G Roos; Deborah Schrag; Thomas Steuber; Bertrand Tombal; Jean-Paul van Basten; Jacobus J M van der Hoeven; David F Penson Journal: Eur Urol Date: 2015-06-28 Impact factor: 20.096
Authors: Wendy W T Lam; Michael A Tse; Chris N L Ng; Edward K M Chung; Richard Fielding Journal: J Pain Symptom Manage Date: 2017-04-22 Impact factor: 3.612
Authors: Ewout W Steyerberg; Andrew J Vickers; Nancy R Cook; Thomas Gerds; Mithat Gonen; Nancy Obuchowski; Michael J Pencina; Michael W Kattan Journal: Epidemiology Date: 2010-01 Impact factor: 4.822
Authors: Andrew J Vickers; Caroline J Savage; Marwan Shouery; James A Eastham; Peter T Scardino; Ethan M Basch Journal: Health Qual Life Outcomes Date: 2010-08-05 Impact factor: 3.186
Authors: Udit Singhal; Ted A Skolarus; John L Gore; Matthew G Parry; Ronald C Chen; Julie Nossiter; Alan Paniagua-Cruz; Arvin K George; Paul Cathcart; Jan van der Meulen; Daniela A Wittmann Journal: Nat Rev Urol Date: 2022-03-08 Impact factor: 16.430
Authors: Nnenaya Agochukwu-Mmonu; Adharsh Murali; Daniela Wittmann; Brian Denton; Rodney L Dunn; James Montie; James Peabody; David Miller; Karandeep Singh Journal: Eur Urol Open Sci Date: 2022-04-18
Authors: Hannah Lamberg; Prasad R Shankar; Karandeep Singh; Elaine M Caoili; Arvin K George; Caitlin Hackett; Anna Johnson; Matthew S Davenport Journal: Radiology Date: 2022-01-18 Impact factor: 29.146
Authors: Gregory B Auffenberg; Ji Qi; Rodney L Dunn; Susan Linsell; Tae Kim; David C Miller; Jeffrey Tosoian; Richard Sarle; William K Johnston; Eduardo Kleer; Khurshid R Ghani; James Montie; James Peabody Journal: JAMA Surg Date: 2021-03-10 Impact factor: 14.766
Authors: Graham R Hale; Mohammed Shahait; David I Lee; Daniel J Lee; Ryan W Dobbs Journal: Patient Prefer Adherence Date: 2021-06-23 Impact factor: 2.711