| Literature DB >> 30572576 |
Anand Tatikonda1, Ville P Jokinen2, Hanno Evard3, Sami Franssila4.
Abstract
The low fabrication cost of SU-8-based devices has opened the fields of point-of-care devices (POC), µTAS and Lab-on-Chip technologies, which call for cheap and disposable devices. Often this translates to free-standing, suspended devices and a reusable carrier wafer. This necessitates a sacrificial layer to release the devices from the substrates. Both inorganic (metals and oxides) and organic materials (polymers) have been used as sacrificial materials, but they fall short for fabrication and releasing multilayer SU-8 devices. We propose photoresist AZ 15nXT (MicroChemicals GmbH, Ulm, Germany) to be used as a sacrificial layer. AZ 15nXT is stable during SU-8 processing, making it suitable for fabricating free-standing multilayer devices. We show two methods for cross-linking AZ 15nXT for stable sacrificial layers and three routes for sacrificial release of the multilayer SU-8 devices. We demonstrate the capability of our release processes by fabrication of a three-layer free-standing microfluidic electrospray ionization (ESI) chip and a free-standing multilayer device with electrodes in a microchannel.Entities:
Keywords: AZ 15nXT; SU-8; free standing; microchips; microfabrication; microfluidics; multi layered chips; sacrificial release
Year: 2018 PMID: 30572576 PMCID: PMC6316518 DOI: 10.3390/mi9120673
Source DB: PubMed Journal: Micromachines (Basel) ISSN: 2072-666X Impact factor: 2.891
Figure 1Schematics of multilayer SU-8 free-standing microfluidic device for mass spectroscopy electro spray ionization. (a) the multilayered SU-8 ESI chip (b) SU-8 chip with extra metallization step.
Figure 2Microfabricated multilayer SU-8 chips (a) the multilayered SU-8 electrospray ionization (ESI) chip for mass spectrometer analysis (b) metalized SU-8 chip with electrodes. The insert shows the channels which are metalized by lift-off.
Figure 3(a) Multilayer SU-8 devices fabricated on AZ 15nXT on silicon wafer before release (b) Free-standing SU-8 ESI chips after releasing from the substrate (c) Silicon wafer after releasing by wet Technistrip assisted release (Method 1 or 2), which leaves very little residue and can be reused with simple cleaning steps (d) silicon wafer after releasing from thermal assisted Technistrip release (Method 3), which leaves more residues. Insert shows the released chips. Residual AZ 15nXT from chips can be removed by incubating for more time in Technistrip.
Figure 4Multilayer SU-8 devices fabrication, during the first layer development (a) AZ 15nXT thermally cross-linked (b) AZ 15nXT UV cross-linked (c) Omni coat and (d) PMGI in place of AZ 15nXT. The SU-8 surfaces have delaminated from the silicon substrate when we have OmniCoat or PMGI are used as sacrificial layers making the multilayer process impossible. The first layer is quite stable when we have used AZ 15nXT as sacrificial layer. Insert shows the zoomed in section of the wafer where in (a,b) the pattern is intact in (c,d) the patterns have peeled off from the surface.
Figure 5MS spectra for Verapamil (a) internal standards were protonated verapamil at m/z 455.3 (b) Limit of detection for S/N of 2.5 was 3.6 nM with correlation coefficient of 0.97.