Ivan E Porter1, William C Palmer2, Alexander S Parker3, David O Hodge4, Nancy N Diehl4, William E Haley1. 1. Division of Nephrology & Hypertension, Mayo Clinic, Jacksonville, FL, United States. 2. Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States. 3. Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, United States. 4. Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, United States.
Abstract
BACKGROUND AND AIMS: Nephrolithiasis is known to be associated with several systemic diseases including chronic kidney disease and renal failure, which can also occur as a complication of chronic liver disease (CLD). This study aimed to assess the prevalence of nephrolithiasis in patients with CLD. METHODS: A short survey was completed by 198 patients with CLD and 322 controls matched by age, sex, and state of residence. A primary diagnosis of liver disease was confirmed with health record review. RESULTS: The median age of the liver disease group was 63 years and 128 (65%) were male; the median age of the control group was 63 and 199 (63%) were male. Body mass index was higher in the liver disease group (27.8 vs 26.7, P < .01). The most common liver disease diagnosis was hepatitis C (60 [30%]) followed by alcoholic cirrhosis (42 [21.2%]). The self-reported prevalence of nephrolithiasis in the liver disease group was 26%, compared to 14% in the control group (P < .01). This association remained significant after adjusting for age, sex, body mass index, and family history of kidney stones or liver disease. CONCLUSIONS: In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.
BACKGROUND AND AIMS: Nephrolithiasis is known to be associated with several systemic diseases including chronic kidney disease and renal failure, which can also occur as a complication of chronic liver disease (CLD). This study aimed to assess the prevalence of nephrolithiasis in patients with CLD. METHODS: A short survey was completed by 198 patients with CLD and 322 controls matched by age, sex, and state of residence. A primary diagnosis of liver disease was confirmed with health record review. RESULTS: The median age of the liver disease group was 63 years and 128 (65%) were male; the median age of the control group was 63 and 199 (63%) were male. Body mass index was higher in the liver disease group (27.8 vs 26.7, P < .01). The most common liver disease diagnosis was hepatitis C (60 [30%]) followed by alcoholic cirrhosis (42 [21.2%]). The self-reported prevalence of nephrolithiasis in the liver disease group was 26%, compared to 14% in the control group (P < .01). This association remained significant after adjusting for age, sex, body mass index, and family history of kidney stones or liver disease. CONCLUSIONS: In this case-control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.
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