Nayara Sabrina F Alves1, William N Setzer2, Joyce Kelly R da Silva3. 1. Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, 66075-900 Belém, Brazil. Electronic address: nayara.alves@icb.ufpa.br. 2. Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA. Electronic address: setzerw@uah.edu. 3. Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, 66075-900 Belém, Brazil. Electronic address: joycekellys@ufpa.br.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Peperomia pellucida (L.) Kunth is an annual weed with a preference to humid places with reduced solar radiation. This plant is mainly distributed in the Neotropics, Africa, Southeast Asia, and Australia. It is popularly employed in the treatment of a variety of health conditions such as abscesses, abdominal pain, skin sores, conjunctivitis, measles, and kidney troubles. Several studies have also described its antimicrobial, cytotoxic, antidiabetic and a variety of other bioactivities. THE AIM OF THE REVIEW: The aim of this work is to evaluate, using a critical review, the present ethnomedicinal applications, phytochemistry and pharmacological studies of P. pellucida essential oils (EOs) and extracts from different locations around the world. MATERIALS AND METHODS: This review was performed through an online survey of the ethnomedicinal practices, chemical compositions and pharmacological applications of P. pellucida EOs and extracts. The data were mainly obtained from online journals and books published in English, Portuguese and Spanish. The information was collected from websites such as Google, Google Scholar, PubMed, Science Direct, ResearchGate and other online databases that provided more information about this herb. RESULTS: Peperomia pellucida bioactivities such as antimicrobial, cytotoxic, antioxidant, fracture healing, antidiabetic and anti-hypercholesterolemia have been described in several literature sources. Nonetheless, most reports only provide the phytochemical screening of extracts, which does not allow the identification of the active compounds. From these studies, some reported constituents are not included in the Dictionary of Natural Products (DNP), which raises questions toward their identification. In addition, some biological assays were even performed without standard controls for comparison which also makes these results questionable. CONCLUSION: This review evaluates data regarding the phytopharmaceutical potential of P. pellucida. In general, several important aspects were questionable or missing in these manuscripts, which points out the need of more investigation on the pharmacological properties and phytochemical compositions of this herb.
ETHNOPHARMACOLOGICAL RELEVANCE: Peperomia pellucida (L.) Kunth is an annual weed with a preference to humid places with reduced solar radiation. This plant is mainly distributed in the Neotropics, Africa, Southeast Asia, and Australia. It is popularly employed in the treatment of a variety of health conditions such as abscesses, abdominal pain, skin sores, conjunctivitis, measles, and kidney troubles. Several studies have also described its antimicrobial, cytotoxic, antidiabetic and a variety of other bioactivities. THE AIM OF THE REVIEW: The aim of this work is to evaluate, using a critical review, the present ethnomedicinal applications, phytochemistry and pharmacological studies of P. pellucida essential oils (EOs) and extracts from different locations around the world. MATERIALS AND METHODS: This review was performed through an online survey of the ethnomedicinal practices, chemical compositions and pharmacological applications of P. pellucida EOs and extracts. The data were mainly obtained from online journals and books published in English, Portuguese and Spanish. The information was collected from websites such as Google, Google Scholar, PubMed, Science Direct, ResearchGate and other online databases that provided more information about this herb. RESULTS: Peperomia pellucida bioactivities such as antimicrobial, cytotoxic, antioxidant, fracture healing, antidiabetic and anti-hypercholesterolemia have been described in several literature sources. Nonetheless, most reports only provide the phytochemical screening of extracts, which does not allow the identification of the active compounds. From these studies, some reported constituents are not included in the Dictionary of Natural Products (DNP), which raises questions toward their identification. In addition, some biological assays were even performed without standard controls for comparison which also makes these results questionable. CONCLUSION: This review evaluates data regarding the phytopharmaceutical potential of P. pellucida. In general, several important aspects were questionable or missing in these manuscripts, which points out the need of more investigation on the pharmacological properties and phytochemical compositions of this herb.
Authors: Nguyen Huy Hung; Prabodh Satyal; Ho Viet Hieu; Nguyen Thi Hong Chuong; Do Ngoc Dai; Le Thi Huong; Thieu Anh Tai; William N Setzer Journal: Insects Date: 2019-02-03 Impact factor: 2.769
Authors: Amanda Pâmela Santos Queiroz; Manolo Cleiton Costa Freitas; José Rogério A Silva; Anderson Bentes Lima; Leila Sawada; Rayan Fidel Martins Monteiro; Ana Carolina Gomes Albuquerque de Freitas; Luís Antônio Loureiro Maués; Alberto Cardoso Arruda; Milton Nascimento Silva; Cristiane Socorro Ferraz Maia; Enéas Andrade Fontes-Júnior; José Luiz M do Nascimento; Mara Silvia P Arruda; Gilmara N T Bastos Journal: PLoS One Date: 2020-09-17 Impact factor: 3.240
Authors: Késsia do Socorro Miranda Mesquita; Bruna de Souza Feitosa; Jorddy Neves Cruz; Oberdan Oliveira Ferreira; Celeste de Jesus Pereira Franco; Márcia Moraes Cascaes; Mozaniel Santana de Oliveira; Eloisa Helena de Aguiar Andrade Journal: Molecules Date: 2021-12-03 Impact factor: 4.411
Authors: Êni S Carvalho; Vanessa F S Ayres; Midiã R Oliveira; Geone M Corrêa; Renata Takeara; Anderson C Guimarães; Mariana B Santiago; Thaís A S Oliveira; Carlos H G Martins; Antônio E M Crotti; Eliane O Silva Journal: Pharmaceuticals (Basel) Date: 2022-08-06
Authors: Nayara Sabrina Freitas Alves; Suzana G Kaory Inoue; Adriana Ribeiro Carneiro; Ulisses Brigatto Albino; William N Setzer; José Guilherme Maia; Eloisa Helena Andrade; Joyce Kelly R da Silva Journal: PLoS One Date: 2022-01-21 Impact factor: 3.240
Authors: Paulo Wender P Gomes; Hugo Barretto; José Diogo E Reis; Abraão Muribeca; Alice Veloso; Carlos Albuquerque; Andrew Teixeira; Wandson Braamcamp; Sônia Pamplona; Consuelo Silva; Milton Silva Journal: Molecules Date: 2022-03-11 Impact factor: 4.411