Literature DB >> 30561665

Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.

Sarah A Cooley1, Jeremy F Strain1, Helen Beaumont1, Anna H Boerwinkle1, John Doyle1, John C Morris1, Tammie L Benzinger2, Beau M Ances1,2,3.   

Abstract

Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Alzheimer’s disease; HIV dementia; positron emission tomography

Mesh：

Year:  2019        PMID： 30561665      PMCID： PMC6548892          DOI： 10.1093/infdis/jiy663

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

Review 1.  Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer's Disease: an Emerging Issue in Geriatric NeuroHIV.

Authors:  Benedetta Milanini; Victor Valcour
Journal:  Curr HIV/AIDS Rep       Date:  2017-08       Impact factor: 5.071

2.  Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study.

Authors:  B M Ances; J J Christensen; M Teshome; J Taylor; C Xiong; P Aldea; A M Fagan; D M Holtzman; J C Morris; M A Mintun; D B Clifford
Journal:  Neurology       Date:  2010-06-09       Impact factor: 9.910

3.  AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure.

Authors:  Shruti Mishra; Brian A Gordon; Yi Su; Jon Christensen; Karl Friedrichsen; Kelley Jackson; Russ Hornbeck; David A Balota; Nigel J Cairns; John C Morris; Beau M Ances; Tammie L S Benzinger
Journal:  Neuroimage       Date:  2017-07-26       Impact factor: 6.556

4.  CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.

Authors:  B J Brew; L Pemberton; K Blennow; A Wallin; L Hagberg
Journal:  Neurology       Date:  2005-11-08       Impact factor: 9.910

5.  CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease.

Authors:  D B Clifford; A M Fagan; D M Holtzman; J C Morris; M Teshome; A R Shah; J S K Kauwe
Journal:  Neurology       Date:  2009-11-11       Impact factor: 9.910

6.  PET Imaging of Tau Deposition in the Aging Human Brain.

Authors:  Michael Schöll; Samuel N Lockhart; Daniel R Schonhaut; James P O'Neil; Mustafa Janabi; Rik Ossenkoppele; Suzanne L Baker; Jacob W Vogel; Jamie Faria; Henry D Schwimmer; Gil D Rabinovici; William J Jagust
Journal:  Neuron       Date:  2016-03-02       Impact factor: 17.173

Review 7.  Neurodegeneration and ageing in the HAART era.

Authors:  Bruce J Brew; S M Crowe; A Landay; Lucette A Cysique; Gilles Guillemin
Journal:  J Neuroimmune Pharmacol       Date:  2008-12-06       Impact factor: 4.147

8.  Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.

Authors:  Marta Marquié; Marc D Normandin; Charles R Vanderburg; Isabel M Costantino; Elizabeth A Bien; Lisa G Rycyna; William E Klunk; Chester A Mathis; Milos D Ikonomovic; Manik L Debnath; Neil Vasdev; Bradford C Dickerson; Stephen N Gomperts; John H Growdon; Keith A Johnson; Matthew P Frosch; Bradley T Hyman; Teresa Gómez-Isla
Journal:  Ann Neurol       Date:  2015-09-25       Impact factor: 10.422

9.  Defining neurocognitive impairment in HIV: deficit scores versus clinical ratings.

Authors:  K Blackstone; D J Moore; D R Franklin; D B Clifford; A C Collier; C M Marra; B B Gelman; J C McArthur; S Morgello; D M Simpson; R J Ellis; J H Atkinson; I Grant; R K Heaton
Journal:  Clin Neuropsychol       Date:  2012-06-18       Impact factor: 3.535

Review 10.  The role of tau protein in HIV-associated neurocognitive disorders.

Authors:  Lecia A M Brown; James Scarola; Adam J Smith; Paul R Sanberg; Jun Tan; Brian Giunta
Journal:  Mol Neurodegener       Date:  2014-10-10       Impact factor: 14.195
View more
  4 in total

Review 1.  Brain PET Imaging: Value for Understanding the Pathophysiology of HIV-associated Neurocognitive Disorder (HAND).

Authors:  Sanhita Sinharay; Dima A Hammoud
Journal:  Curr HIV/AIDS Rep       Date:  2019-02       Impact factor: 5.071

2.  Signatures of somatosensory cortical dysfunction in Alzheimer's disease and HIV-associated neurocognitive disorder.

Authors:  Chloe C Casagrande; Alex I Wiesman; Mikki Schantell; Hallie J Johnson; Sara L Wolfson; Jennifer O'Neill; Craig M Johnson; Pamela E May; Susan Swindells; Daniel L Murman; Tony W Wilson
Journal:  Brain Commun       Date:  2022-06-23

3.  Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders.

Authors:  Erin E Sundermann; Mark W Bondi; Laura M Campbell; Ben Gouaux; Raeanne C Moore; Virawudh Soontornniyomkij; David J Moore
Journal:  J Infect Dis       Date:  2021-08-02       Impact factor: 5.226

4.  Patterns of Cerebrospinal Fluid Alzheimer's Dementia Biomarkers in People Living with HIV: Cross-Sectional Study on Associated Factors According to Viral Control, Neurological Confounders and Neurocognition.

Authors:  Mattia Trunfio; Cristiana Atzori; Marta Pasquero; Alessandro Di Stefano; Daniela Vai; Marco Nigra; Daniele Imperiale; Stefano Bonora; Giovanni Di Perri; Andrea Calcagno
Journal:  Viruses       Date:  2022-04-04       Impact factor: 5.818
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.