Man-Chin Hua1,2, Hui-Min Su3, Ming-Ling Kuo4,5, Chien-Chang Chen2,6, Tsung-Chieh Yao2,4, Ming-Han Tsai1,2, Sui-Ling Liao1,2, Shen-Hao Lai2,7, Chih-Yung Chiu1,2, Kuan-Wen Su1,2, Li-Chen Chen2,4, Kuo-Wei Yeh2,4, Jing-Long Huang2,4. 1. Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan. 2. Chang Gung University College of Medicine, Taoyuan, Taiwan. 3. Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan. 4. Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5. Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 6. Division of Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 7. Division of Chest, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Abstract
BACKGROUND: This study aimed to investigate whether maternal allergy is associated with soluble CD14 (sCD14) and fatty acid composition in different stages of lactation and the onset of atopic dermatitis (AD) in early childhood. METHODS: In total, 443 mother-child groups (445 children) were enrolled in the Prediction of Allergies in Taiwanese Children birth cohort study. Colostrum and mature milk at 2 months postpartum (2-month HM) were collected from lactating mothers. Information regarding parental allergy histories and physician-diagnosed atopic diseases was obtained using age-specific questionnaires (0-2 years). We compared sCD14 levels and the composition of 30 fatty acids in the colostrum and 2-month HM, respectively, between allergic and non-allergic mothers and between children with and without AD by the age of 2 years. RESULTS: In total, 185 (41.8%) mothers presented with allergies, and 154 (34.6%) children had physician-diagnosed AD by the age of 2 years. Both in the colostrum and 2-month HM of 289 lactating mothers, sCD14 levels were significantly lower in allergic mothers whose children presented with AD compared with children who did not (P = 0.015 and 0.044, respectively). Among the children with AD who were born to non-allergic mothers, sCD14 levels were lower. However, the result was not statistically significant (P = 0.376 and 0.264, respectively). Our data revealed the lack of associations between fatty acid composition and AD (P > 0.05). CONCLUSION: Decreased sCD14 levels in the colostrum and 2-month HM were associated with AD at 2 years of age, particularly among children born to mothers with allergies.
BACKGROUND: This study aimed to investigate whether maternal allergy is associated with soluble CD14 (sCD14) and fatty acid composition in different stages of lactation and the onset of atopic dermatitis (AD) in early childhood. METHODS: In total, 443 mother-child groups (445 children) were enrolled in the Prediction of Allergies in Taiwanese Children birth cohort study. Colostrum and mature milk at 2 months postpartum (2-month HM) were collected from lactating mothers. Information regarding parental allergy histories and physician-diagnosed atopic diseases was obtained using age-specific questionnaires (0-2 years). We compared sCD14 levels and the composition of 30 fatty acids in the colostrum and 2-month HM, respectively, between allergic and non-allergic mothers and between children with and without AD by the age of 2 years. RESULTS: In total, 185 (41.8%) mothers presented with allergies, and 154 (34.6%) children had physician-diagnosed AD by the age of 2 years. Both in the colostrum and 2-month HM of 289 lactating mothers, sCD14 levels were significantly lower in allergic mothers whose children presented with AD compared with children who did not (P = 0.015 and 0.044, respectively). Among the children with AD who were born to non-allergic mothers, sCD14 levels were lower. However, the result was not statistically significant (P = 0.376 and 0.264, respectively). Our data revealed the lack of associations between fatty acid composition and AD (P > 0.05). CONCLUSION: Decreased sCD14 levels in the colostrum and 2-month HM were associated with AD at 2 years of age, particularly among children born to mothers with allergies.
Authors: Lisa F Stinson; Melvin C L Gay; Petya T Koleva; Merete Eggesbø; Christine C Johnson; Ganesa Wegienka; Elloise du Toit; Naoki Shimojo; Daniel Munblit; Dianne E Campbell; Susan L Prescott; Donna T Geddes; Anita L Kozyrskyj Journal: Front Immunol Date: 2020-07-21 Impact factor: 7.561
Authors: Linda P Siziba; Leonie Lorenz; Bernd Stahl; Marko Mank; Tamas Marosvölgyi; Tamas Decsi; Dietrich Rothenbacher; Jon Genuneit Journal: Nutrients Date: 2020-06-10 Impact factor: 5.717