Literature DB >> 30559135

Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China.

Lingbin Shu1, Ning Dong2,3, Jun Lu4, Zhiwei Zheng2,3, Jie Hu1, Wenqing Zeng4, Qiaoling Sun1, Edward Wai-Chi Chan2,3, Hongwei Zhou1, Fupin Hu5,6, Sheng Chen7,3, Rong Zhang8.   

Abstract

This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The bla OXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Klebsiella pneumoniaezzm321990; OXA-232; clonal spread; virulence plasmid; virulence potential

Mesh:

Substances:

Year:  2019        PMID: 30559135      PMCID: PMC6395905          DOI: 10.1128/AAC.02246-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  35 in total

Review 1.  The Global Ascendency of OXA-48-Type Carbapenemases.

Authors:  Johann D D Pitout; Gisele Peirano; Marleen M Kock; Kathy-Anne Strydom; Yasufumi Matsumura
Journal:  Clin Microbiol Rev       Date:  2019-11-13       Impact factor: 26.132

2.  Two Hypervirulent Klebsiella pneumoniae Isolates Producing a bla KPC-2 Carbapenemase from a Canadian Patient.

Authors:  Laura F Mataseje; David A Boyd; Michael R Mulvey; Yves Longtin
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

3.  Identification of a Novel Ceftazidime-Avibactam-Resistant KPC-2 Variant, KPC-123, in Citrobacter koseri Following Ceftazidime-Avibactam Treatment.

Authors:  Lin Wang; Weiyi Shen; Rong Zhang; Jiachang Cai
Journal:  Front Microbiol       Date:  2022-06-20       Impact factor: 6.064

Review 4.  Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives.

Authors:  J E Choby; J Howard-Anderson; D S Weiss
Journal:  J Intern Med       Date:  2019-11-21       Impact factor: 8.989

5.  The Characterization of OXA-232 Carbapenemase-Producing ST437 Klebsiella pneumoniae in China.

Authors:  Xingbei Weng; Qiucheng Shi; Sheng Wang; Yubo Shi; Dinghe Sun; Yunsong Yu
Journal:  Can J Infect Dis Med Microbiol       Date:  2020-07-08       Impact factor: 2.471

6.  Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) Among Carbapenem-Resistant Enterobacteriaceae Isolated From Adult and Children Patients in China.

Authors:  Renru Han; Qingyu Shi; Shi Wu; Dandan Yin; Mingjia Peng; Dong Dong; Yonggui Zheng; Yan Guo; Rong Zhang; Fupin Hu
Journal:  Front Cell Infect Microbiol       Date:  2020-07-03       Impact factor: 5.293

7.  Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae.

Authors:  Miaomiao Xie; Xuemei Yang; Qi Xu; Lianwei Ye; Kaichao Chen; Zhiwei Zheng; Ning Dong; Qiaoling Sun; Lingbin Shu; Danxia Gu; Edward Wai-Chi Chan; Rong Zhang; Sheng Chen
Journal:  Commun Biol       Date:  2021-06-01

8.  A fatal case of liver abscess caused by hypervirulent Klebsiella pneumoniae in a diabetic adolescent: A clinical and laboratory study.

Authors:  Yue Li; Zheng Li; Suyun Qian; Fang Dong; Qing Wang; Pengfei Zhang; Kaihu Yao
Journal:  Pediatr Investig       Date:  2021-01-26

9.  Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin.

Authors:  Xi Jin; Qiong Chen; Fang Shen; Yan Jiang; Xueqing Wu; Xiaoting Hua; Ying Fu; Yunsong Yu
Journal:  Emerg Microbes Infect       Date:  2021-12       Impact factor: 7.163

10.  High clinical impact of rapid susceptibility testing on CHROMID ESBL® medium directly from swabs.

Authors:  Álvaro Romo-Ibáñez; Elisabeth Calatrava-Hernández; Blanca Gutiérrez-Soto; Mercedes Pérez-Ruiz; José María Navarro-Marí; José Gutiérrez-Fernández
Journal:  Ann Transl Med       Date:  2020-05
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