Amy Downing1, Adam W Glaser2, Paul J Finan2, Penny Wright3, James D Thomas4, Alexandra Gilbert3, Jessica Corner5, Mike Richards6, Eva J A Morris2, David Sebag-Montefiore3. 1. Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Institute of Data Analytics, University of Leeds, Leeds, UK. Electronic address: a.downing@leeds.ac.uk. 2. Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Institute of Data Analytics, University of Leeds, Leeds, UK. 3. Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. 4. Public Health England, Blenheim House, Leeds, UK. 5. Faculty of Executive Office, University of Nottingham, Nottingham, UK. 6. The Health Foundation, London, UK.
Abstract
PURPOSE: There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigated how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life using data from a large-scale survey of patient-reported outcomes. METHODS AND MATERIALS: All individuals 12 to 36 months after receiving a diagnosis of colorectal cancer in England were sent a survey in January 2013. The survey responses were linked with cancer registration, hospital admissions, and radiation therapy data through the National Cancer Registration and Analysis Service. Outcome measures were cancer specific (Functional Assessment of Cancer Therapy and Social Difficulties Inventory items related to fecal incontinence, urinary incontinence, and sexual difficulties) and generic (EuroQol EQ-5D). RESULTS: Surveys were returned by 6713 (64.2%) of 10,452 patients with rectal cancer. Of these, 3998 patients were in remission after a major resection and formed the final analysis sample. Compared with those who had surgery alone, patients who received preoperative radiation therapy had higher odds of reporting poor bowel control (43.6% vs 33.0%; odds ratio [OR] = 1.55; 95% confidence interval [CI], 1.26-1.91), severe urinary leakage (7.2% vs 3.5%; OR = 1.69; 95% CI, 1.18-2.43), and severe sexual difficulties (34.4% vs 18.3%; OR = 1.73; 95% CI, 1.43-2.11). Patients who received long-course chemoradiotherapy reported significantly better bowel control than those who had short-course radiation therapy, with no difference for other outcomes. Respondents with a stoma present reported significantly higher levels of severe sexual difficulties and worse health-related quality of life than those who had never had a stoma or had undergone stoma reversal. CONCLUSIONS: This study demonstrated the feasibility of a large-scale assessment of patient-reported outcomes and provided "real-world" data regarding the effect of rectal cancer treatment. The results show that patients who receive preoperative radiation therapy reported poorer outcomes, particularly for bowel and sexual function, and highlighted the negative impact of a stoma. We hope that our experience will encourage researchers to perform similar studies in other healthcare systems.
PURPOSE: There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigated how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life using data from a large-scale survey of patient-reported outcomes. METHODS AND MATERIALS: All individuals 12 to 36 months after receiving a diagnosis of colorectal cancer in England were sent a survey in January 2013. The survey responses were linked with cancer registration, hospital admissions, and radiation therapy data through the National Cancer Registration and Analysis Service. Outcome measures were cancer specific (Functional Assessment of Cancer Therapy and Social Difficulties Inventory items related to fecal incontinence, urinary incontinence, and sexual difficulties) and generic (EuroQol EQ-5D). RESULTS: Surveys were returned by 6713 (64.2%) of 10,452 patients with rectal cancer. Of these, 3998 patients were in remission after a major resection and formed the final analysis sample. Compared with those who had surgery alone, patients who received preoperative radiation therapy had higher odds of reporting poor bowel control (43.6% vs 33.0%; odds ratio [OR] = 1.55; 95% confidence interval [CI], 1.26-1.91), severe urinary leakage (7.2% vs 3.5%; OR = 1.69; 95% CI, 1.18-2.43), and severe sexual difficulties (34.4% vs 18.3%; OR = 1.73; 95% CI, 1.43-2.11). Patients who received long-course chemoradiotherapy reported significantly better bowel control than those who had short-course radiation therapy, with no difference for other outcomes. Respondents with a stoma present reported significantly higher levels of severe sexual difficulties and worse health-related quality of life than those who had never had a stoma or had undergone stoma reversal. CONCLUSIONS: This study demonstrated the feasibility of a large-scale assessment of patient-reported outcomes and provided "real-world" data regarding the effect of rectal cancer treatment. The results show that patients who receive preoperative radiation therapy reported poorer outcomes, particularly for bowel and sexual function, and highlighted the negative impact of a stoma. We hope that our experience will encourage researchers to perform similar studies in other healthcare systems.
Authors: Winson J Tan; Sujata Patil; Jose G Guillem; Philip B Paty; Martin R Weiser; Garrett M Nash; J Joshua Smith; Emmanouil P Pappou; Iris H Wei; Julio Garcia-Aguilar Journal: Dis Colon Rectum Date: 2021-01 Impact factor: 4.412
Authors: Eva J A Morris; Raphael Goldacre; Enti Spata; Marion Mafham; Paul J Finan; Jon Shelton; Mike Richards; Katie Spencer; Jonathan Emberson; Sam Hollings; Paula Curnow; Dominic Gair; David Sebag-Montefiore; Chris Cunningham; Matthew D Rutter; Brian D Nicholson; Jem Rashbass; Martin Landray; Rory Collins; Barbara Casadei; Colin Baigent Journal: Lancet Gastroenterol Hepatol Date: 2021-01-15
Authors: Nicole L Stout; Daniel Santa Mina; Kathleen D Lyons; Karen Robb; Julie K Silver Journal: CA Cancer J Clin Date: 2020-10-27 Impact factor: 508.702
Authors: Hans Geinitz; Carsten Nieder; Lukas Kocik; Christine Track; Johann Feichtinger; Theresa Weingartner; Kurt Spiegl; Barbara Füreder-Kitzmüller; Johanna Kaufmann; Dietmar H Seewald; Reinhold Függer; Andreas Shamiyeh; Andreas L Petzer; David Kiesl; Josef Hammer Journal: Radiat Oncol Date: 2020-05-14 Impact factor: 3.481