Maria Eduarda Brandão Bueno1, Luiz Inácio do Nascimento Neto2, Marcelle Brandão Terra3, Natália Mariano Barboza4, Alexandre Hideki Okano5, Suhaila Mahmoud Smaili6. 1. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address: m.eduardafit@gmail.com. 2. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address: luizinacio50@gmail.com. 3. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address: celleterra@gmail.com. 4. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address: nat_barboza@hotmail.com. 5. State University of ABC, Dos Estados Av., 5001, Santo André, São Paulo, Brazil. Electronic address: emaildookano@gmail.com. 6. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address: suhailaneuro@gmail.com.
Abstract
BACKGROUND:Transcranial direct current stimulation (tDCS) is an appropriate treatment for Parkinson's disease (PD). It offers promising results and is known to improve symptoms. Nevertheless, consistent parameters need to be established for research purposes. OBJECTIVE: To verify the effectiveness of acute tDCS on non-motor and motor symptoms in PD. METHODS: A double-blind, randomized and sham-controlled study, in which twenty individuals randomly underwent two (one real, one sham) stimulation sessions. The current was applied to the dorsolateral prefrontal cortex (DLPFC) for 20 min at 2 mA. Participants were assessed before and after the stimulation using the Trail Making Test (TMT), Verbal Fluency test, Stroop test, Timed Up and Go test and video gait analysis. In the statistical analysis, a two-way variance analysis of repeated measures was applied to the variables time, group and time vs. group interaction, using Sidak's post-hoc test. RESULTS: Statistically significant differences were found for TMT part B in both groups. For the Verbal Fluency test differences were found only within the group that received real stimulation. Additionally, both groups revealed improved reaction time in the congruent, incongruent and total phases of the Stroop test, but a significant difference in the Stroop effect was found only within the group that received real stimulation. CONCLUSION: The results confirm that improvements on cognitive tests are possible after a single session of DLPFC stimulation.
RCT Entities:
BACKGROUND: Transcranial direct current stimulation (tDCS) is an appropriate treatment for Parkinson's disease (PD). It offers promising results and is known to improve symptoms. Nevertheless, consistent parameters need to be established for research purposes. OBJECTIVE: To verify the effectiveness of acute tDCS on non-motor and motor symptoms in PD. METHODS: A double-blind, randomized and sham-controlled study, in which twenty individuals randomly underwent two (one real, one sham) stimulation sessions. The current was applied to the dorsolateral prefrontal cortex (DLPFC) for 20 min at 2 mA. Participants were assessed before and after the stimulation using the Trail Making Test (TMT), Verbal Fluency test, Stroop test, Timed Up and Go test and video gait analysis. In the statistical analysis, a two-way variance analysis of repeated measures was applied to the variables time, group and time vs. group interaction, using Sidak's post-hoc test. RESULTS: Statistically significant differences were found for TMT part B in both groups. For the Verbal Fluency test differences were found only within the group that received real stimulation. Additionally, both groups revealed improved reaction time in the congruent, incongruent and total phases of the Stroop test, but a significant difference in the Stroop effect was found only within the group that received real stimulation. CONCLUSION: The results confirm that improvements on cognitive tests are possible after a single session of DLPFC stimulation.
Authors: Diana M A Suarez-García; Johan S Grisales-Cárdenas; Máximo Zimerman; Juan F Cardona Journal: Front Neurol Date: 2020-11-30 Impact factor: 4.003
Authors: Thaísa Dias de Carvalho Costa; Clécio Godeiro Júnior; Rodrigo Alencar E Silva; Silmara Freitas Dos Santos; Daniel Gomes da Silva Machado; Suellen Marinho Andrade Journal: Front Neurol Date: 2022-03-02 Impact factor: 4.003