Catherine Guezennec1, Philippe Robin1, Fanny Orlhac2, David Bourhis1, Olivier Delcroix1, Yves Gobel3, Jean Rousset4, Ulrike Schick5, Pierre-Yves Salaün1, Ronan Abgral1. 1. Department of Nuclear Medicine, Brest University Hospital, Brest, France. 2. Imagerie Moléculaire in Vivo, CEA-SHJF, Inserm, CNRS, Université Paris-Sud, Université Paris-Saclay, Orsay, France. 3. Department of Head and Neck Surgery, Brest University Hospital, Brest, France. 4. Department of Radiology, Military Hospital Brest, Brest, France. 5. Department of Radiotherapy, Brest University Hospital, Brest, France.
Abstract
BACKGROUND: This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging. METHODS: Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Prognostic significance of parameters was assessed in univariate and multivariate analysis. RESULTS: Textural indices were extracted in 284 patients (mean age = 63.7±9.6 years). In univariate analysis, MTV and 4 textural indices-Correlation, Entropy, Energy, and Coarseness-were significantly correlated with overall survival (OS). In multivariate analysis, MTV (P = .008) and Correlation (P = .028) remained independently correlated to OS. CONCLUSION: This study showed that MTV and 1 textural index extracted from pretherapeutic FDG-PET/CT (Correlation) were independent prognostic factors of OS in patients with HNSCC.
BACKGROUND: This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging. METHODS: Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Prognostic significance of parameters was assessed in univariate and multivariate analysis. RESULTS: Textural indices were extracted in 284 patients (mean age = 63.7±9.6 years). In univariate analysis, MTV and 4 textural indices-Correlation, Entropy, Energy, and Coarseness-were significantly correlated with overall survival (OS). In multivariate analysis, MTV (P = .008) and Correlation (P = .028) remained independently correlated to OS. CONCLUSION: This study showed that MTV and 1 textural index extracted from pretherapeutic FDG-PET/CT (Correlation) were independent prognostic factors of OS in patients with HNSCC.
Authors: Maryam Gul; Kimberley-Jane C Bonjoc; David Gorlin; Chi Wah Wong; Amirah Salem; Vincent La; Aleksandr Filippov; Abbas Chaudhry; Muhammad H Imam; Ammar A Chaudhry Journal: Front Oncol Date: 2021-07-07 Impact factor: 6.244
Authors: Carlos Miguel Chiesa-Estomba; Oier Echaniz; Ekhiñe Larruscain; Jose Angel Gonzalez-Garcia; Jon Alexander Sistiaga-Suarez; Manuel Graña Journal: Cancers (Basel) Date: 2019-09-20 Impact factor: 6.639