| Literature DB >> 30545854 |
Mingfeng Li, Gabriel Santpere, Yuka Imamura Kawasawa, Oleg V Evgrafov, Forrest O Gulden, Sirisha Pochareddy, Susan M Sunkin, Zhen Li, Yurae Shin, Ying Zhu, André M M Sousa, Donna M Werling, Robert R Kitchen, Hyo Jung Kang, Mihovil Pletikos, Jinmyung Choi, Sydney Muchnik, Xuming Xu, Daifeng Wang, Belen Lorente-Galdos, Shuang Liu, Paola Giusti-Rodríguez, Hyejung Won, Christiaan A de Leeuw, Antonio F Pardiñas, Ming Hu, Fulai Jin, Yun Li, Michael J Owen, Michael C O'Donovan, James T R Walters, Danielle Posthuma, Mark A Reimers, Pat Levitt, Daniel R Weinberger, Thomas M Hyde, Joel E Kleinman, Daniel H Geschwind, Michael J Hawrylycz, Matthew W State, Stephan J Sanders, Patrick F Sullivan, Mark B Gerstein, Ed S Lein, James A Knowles, Nenad Sestan.
Abstract
To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.Entities:
Mesh：
Year: 2018 PMID： 30545854 PMCID： PMC6413317 DOI： 10.1126/science.aat7615
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728