Literature DB >> 5574521

Transport of nitrogen mustard on the transport-carrier for choline in L5178Y lymphoblasts.

G J Goldenberg, C L Vanstone, I Bihler.   

Abstract

The uptake of choline by L5178Y lymphoblasts occurs by a carrier mechanism and is an active process. Transport of nitrogen mustard and its hydrolyzed derivative is mediated by this same carrier. This finding is an example of drug transport by a carrier whose primary function is transport of a naturally occurring substrate.

Entities:  

Mesh：

Substances：

Year:  1971        PMID： 5574521     DOI： 10.1126/science.172.3988.1148

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Resistance to cytostatic drugs at the cellular level.

Authors:  C P Vendrik; J J Bergers; W H De Jong; P A Steerenberg
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 2.  Molecular mechanisms of drug resistance.

Authors:  J D Hayes; C R Wolf
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

3.  Inhibition of giant cell formation by Compound 48-80 after infection with herpesvirus hominis. IV. Compound 48-80, an inhibitor of choline kinase activity.

Authors:  I Just; D Falke
Journal:  Arch Gesamte Virusforsch       Date:  1974

4.  Cytotoxic effect of choline, abolished by furosemide, in the diluting segment of frog kidney.

Authors:  H Oberleithner; F Lang
Journal:  Pflugers Arch       Date:  1984-07       Impact factor: 3.657

5.  A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.

Authors:  E Haase; M Brendel
Journal:  Curr Genet       Date:  1990-10       Impact factor: 3.886

6.  Plasma cell myeloma: response of melphalan-resistant patients to high-dose intermittent cyclophosphamide.

Authors:  D E Bergsagel; D H Cowan; R Hasselback
Journal:  Can Med Assoc J       Date:  1972-11-04       Impact factor: 8.262

7.  In vitro inhibition of human erythrocyte acetylcholinesterase (EC3.1.1.7) by an antineoplastic drug methotrexate.

Authors:  M A Kamal; F H Nasim; A A al-Jafari
Journal:  Mol Cell Biochem       Date:  1996-06-07       Impact factor: 3.396

Review 8.  Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.

Authors:  Michael P Shakarjian; Diane E Heck; Joshua P Gray; Patrick J Sinko; Marion K Gordon; Robert P Casillas; Ned D Heindel; Donald R Gerecke; Debra L Laskin; Jeffrey D Laskin
Journal:  Toxicol Sci       Date:  2009-10-15       Impact factor: 4.849

9.  Toxic effects of mechlorethamine on mammalian respiratory mucociliary epithelium in primary culture.

Authors:  I Giuliani; E Boivieux-Ulrich; O Houcine; C Guennou; F Marano
Journal:  Cell Biol Toxicol       Date:  1994-08       Impact factor: 6.691

10.  Hyper-resistance to nitrogen mustard in Saccharomyces cerevisiae is caused by defective choline transport.

Authors:  Z Y Li; E Haase; M Brendel
Journal:  Curr Genet       Date:  1991-06       Impact factor: 3.886
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.