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Literature DB >> 30543772

Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight.

Abstract

The restriction factor TRIM5α recognizes incoming retroviral capsids and blocks virus replication. In this issue of Cell Host & Microbe, Fletcher et al. (2018) show how the TRIM5α RING domain mediates formation of various ubiquitin conjugates that differentially regulate TRIM5α turnover, inhibition of viral reverse transcription, and innate immune activation.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2018 PMID： 30543772 PMCID： PMC6464375 DOI： 10.1016/j.chom.2018.11.013

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

10 in total

1. Hexagonal assembly of a restricting TRIM5alpha protein.

Authors: Barbie K Ganser-Pornillos; Viswanathan Chandrasekaran; Owen Pornillos; Joseph G Sodroski; Wesley I Sundquist; Mark Yeager
Journal: Proc Natl Acad Sci U S A Date: 2010-12-27 Impact factor: 11.205

2. TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction.

Authors: Michael A Mandell; Tomonori Kimura; Ashish Jain; Terje Johansen; Vojo Deretic
Journal: Autophagy Date: 2014 Impact factor: 16.016

3. Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection.

Authors: Xiaolu Wu; Jenny L Anderson; Edward M Campbell; Ajith M Joseph; Thomas J Hope
Journal: Proc Natl Acad Sci U S A Date: 2006-04-28 Impact factor: 11.205

4. RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.

Authors: Zinaida Yudina; Amanda Roa; Rory Johnson; Nikolaos Biris; Daniel A de Souza Aranha Vieira; Vladislav Tsiperson; Natalia Reszka; Alexander B Taylor; P John Hart; Borries Demeler; Felipe Diaz-Griffero; Dmitri N Ivanov
Journal: Cell Rep Date: 2015-07-23 Impact factor: 9.423

5. Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5.

Authors: Felipe Diaz-Griffero; Xing Li; Hassan Javanbakht; Byeongwoon Song; Sohanya Welikala; Matthew Stremlau; Joseph Sodroski
Journal: Virology Date: 2006-02-10 Impact factor: 3.616

6. TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

Authors: Thomas Pertel; Stéphane Hausmann; Damien Morger; Sara Züger; Jessica Guerra; Josefina Lascano; Christian Reinhard; Federico A Santoni; Pradeep D Uchil; Laurence Chatel; Aurélie Bisiaux; Matthew L Albert; Caterina Strambio-De-Castillia; Walther Mothes; Massimo Pizzato; Markus G Grütter; Jeremy Luban
Journal: Nature Date: 2011-04-21 Impact factor: 49.962

7. TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

Authors: Adam J Fletcher; Devin E Christensen; Chad Nelson; Choon Ping Tan; Torsten Schaller; Paul J Lehner; Wesley I Sundquist; Greg J Towers
Journal: EMBO J Date: 2015-06-22 Impact factor: 11.598

8. Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α.

Authors: Jeremy R Keown; Joy X Yang; Jordan Douglas; David C Goldstone
Journal: Sci Rep Date: 2016-05-27 Impact factor: 4.379

9. Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.

Authors: Jonathan M Wagner; Marcin D Roganowicz; Katarzyna Skorupka; Steven L Alam; Devin Christensen; Ginna Doss; Yueping Wan; Gabriel A Frank; Barbie K Ganser-Pornillos; Wesley I Sundquist; Owen Pornillos
Journal: Elife Date: 2016-06-02 Impact factor: 8.140

10. Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.

Authors: Adam J Fletcher; Marina Vaysburd; Sarah Maslen; Jingwei Zeng; J Mark Skehel; Greg J Towers; Leo C James
Journal: Cell Host Microbe Date: 2018-11-29 Impact factor: 21.023