Literature DB >> 30539521

Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer.

Madiha Niyaz1, Mosin S Khan1, Rauf A Wani2, Omar J Shah3, Syed Mudassar4.   

Abstract

Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Only 31.4% (11 of 35) and 26.9% (7 of 26) of colon and rectal cancer cases respectively showed an increase in SHH expression in tumours compared to 72.7% (24 of 33) of the pancreatic cancer cases when compared with their adjacent normal tissues. Our results suggest that SHH may have a strong role in the predisposition of Pancreatic cancer and could possibly be used as a diagnostic or prognostic biomarker.

Entities:  

Keywords:  Colorectal cancer; Hedgehog signalling pathway; Pancreatic cancer; Protein expression; Sonic hedgehog; Western blotting

Mesh：

Substances：

Year:  2018        PMID： 30539521     DOI： 10.1007/s12253-018-00564-2

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  37 in total

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Authors:  James Briscoe; Pascal P Thérond
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05-30       Impact factor: 94.444

Review 2.  Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.

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Journal:  Cancer Cell       Date:  2014-10-13       Impact factor: 31.743

Review 4.  Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer.

Authors:  Hideya Onishi; Mitsuo Katano
Journal:  World J Gastroenterol       Date:  2014-03-07       Impact factor: 5.742

5.  Burden of cancers in the valley of Kashmir: 5 year epidemiological study reveals a different scenario.

Authors:  Arshad A Pandith; Mushtaq A Siddiqi
Journal:  Tumour Biol       Date:  2012-05-19

6.  Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer.

Authors:  Richard Douard; Stéphane Moutereau; Pascal Pernet; Mihelaiti Chimingqi; Yves Allory; Philippe Manivet; Marc Conti; Michel Vaubourdolle; Paul-Henri Cugnenc; Sylvain Loric
Journal:  Surgery       Date:  2006-05       Impact factor: 3.982

7.  Hedgehog signaling pathway is inactive in colorectal cancer cell lines.

Authors:  Guillaume Chatel; Corine Ganeff; Naima Boussif; Laurence Delacroix; Alexandra Briquet; Gregory Nolens; Rosita Winkler
Journal:  Int J Cancer       Date:  2007-12-15       Impact factor: 7.396

8.  Partners in crime: the TGFβ and MAPK pathways in cancer progression.

Authors:  Douglas A Chapnick; Lisa Warner; Jennifer Bernet; Timsi Rao; Xuedong Liu
Journal:  Cell Biosci       Date:  2011-12-28       Impact factor: 7.133

9.  The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.

Authors:  Ashley J Williamson; Michelle E Doscas; Jin Ye; Katherine B Heiden; Mingzhao Xing; Yi Li; Richard A Prinz; Xiulong Xu
Journal:  Oncotarget       Date:  2016-03-01

10.  Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma.

Authors:  S Satheesha; G Manzella; A Bovay; E A Casanova; P K Bode; R Belle; S Feuchtgruber; P Jaaks; N Dogan; E Koscielniak; B W Schäfer
Journal:  Oncogene       Date:  2015-07-20       Impact factor: 9.867
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  2 in total

1.  Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma.

Authors:  Francesca Saini; Richard H Argent; Anna M Grabowska
Journal:  Cells       Date:  2019-05-08       Impact factor: 6.600

2.  Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes.

Authors:  Rami Alzhrani; Hashem O Alsaab; Kushal Vanamal; Ketki Bhise; Katyayani Tatiparti; Ayatakshi Barari; Samaresh Sau; Arun K Iyer
Journal:  Adv Ther (Weinh)       Date:  2021-04-24
  2 in total

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