Udder health in the periparturient period.

The periparturient period is associated with rapid differentiation of secretory parenchyma, intense mammary growth, copious synthesis and secretion, and marked accumulation of colostrum and milk. Udder health during this time is an important factor associated with the production of maximum quantities of high quality milk. Intramammary infections that occur during the dry period can adversely affect udder health, resulting in decreased milk production, altered milk composition, and impaired mammary function. Bovine mammary glands are markedly susceptible to new infections during the periparturient period, especially prior to parturition. Many infections that occur at this time are associated with clinical mastitis during early lactation. Methods of controlling mastitis in the dry period have focused primarily on the use of antibiotics. However, antibiotic therapy at drying off does not appear to prevent new infections in the periparturient period. This is most likely due to lack of persistence of antibiotics. Furthermore, antibiotics used currently are less effective against environmental pathogens, in particular coliform bacteria, which can cause a high proportion of intramammary infections during the periparturient period. Methods of controlling bovine mastitis during the periparturient period is an important area that requires additional research. Procedures need to be developed that are effective against a variety of bacteria, including environmental mastitis pathogens, if additional control is to be achieved.