| Literature DB >> 3053753 |
A E Brown1, H K Webster, S Tulyayon, A Suvarnamani, R A Wirtz, P Sookto.
Abstract
The circumsporozoite (CS) protein on the surface of sporozoites is the major target for antibody response(s) to the infective stage of the malaria parasite. Sera from malaria endemic areas contain both IgM and IgG antibodies that react with a dominant epitope in the tetrapeptide repeat region of the CS protein. In order to characterize the IgM CS antibody response in Plasmodium falciparum (PF) malaria, a prospective study was conducted in Thai Rangers. Variable IgM responses against the CS protein were detected in 81% of 47 PF-infected subjects. Similar to IgG response kinetics, IgM levels rose to a peak 6-10 days after detection of parasitemia and showed an apparent serum half-life of less than 25 days. The classic difference in isotype ratio (IgG/IgM) between primary and secondary antibody responses was observed to blood-stage, but not CS, antigens.Entities:
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Year: 1988 PMID： 3053753 DOI： 10.1007/BF00917149
Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317