| Literature DB >> 30536456 |
Li Wang1, Xiangyu Wang1, Hanyong Chen2, Xueyin Zu1,3, Fayang Ma1,3, Kangdong Liu1,3,4,5, Ann M Bode2, Zigang Dong1,2,5, Dong Joon Kim1.
Abstract
Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities. However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated. In the present study, we report that gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth. Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration. Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins. Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein. Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Our results demonstrate that gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer.Entities:
Keywords: AURKA; RSK2; apoptosis; gastric cancer; gossypin
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Year: 2018 PMID： 30536456 PMCID： PMC6416069 DOI： 10.1002/ptr.6253
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878