Fernanda Pino Vitti1, Carlos Grandi2, Ricardo de Carvalho Cavalli3, Vanda Maria Ferreira Simões4, Rosângela Fernandes Lucena Batista4, Viviane Cunha Cardoso1. 1. Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil. 2. Department of Pediatrics, Facultad de Medicina de la Universidad de Buenos Aires, Argentina. 3. Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil. 4. Department of Public Health, Universidade Federal do Maranhão, São Luiz, MA, Brazil.
Abstract
OBJECTIVE: To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010. METHODS: Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. The women answered standardized questionnaires about reproductive health, prenatal care, life habits, sociodemographic conditions, and information about coffee intake. The independent variable was high caffeine consumption (≥300 mg/day) from coffee during pregnancy, and the dependent variables were LBW (birth weight < 2,500 g) and preterm birth (< 37 weeks of gestational age). Four adjusted polytomous logistic regression models, relative risk (RR) and 95% confidence interval (CI) were fitted: biological and sociodemographic conditions; obstetric history; current gestational conditions; and all variables included in the previous models. RESULTS: A total of 4,908 (64.5%) mothers consumed caffeine, 143 (2.9%) of whom reported high consumption. High caffeine intake was significantly associated with reduced education and with the occupation of the head of the family, nonwhite skin color, not having a partner, higher parity, previous abortion and preterm birth, urinary tract infection, threatened abortion, alcohol consumption and smoking. No association was found between high caffeine consumption and LBW or preterm birth in both unadjusted (RR = 1.45; 95% CI: 0.91-2.32; and RR = 1.16; 95% CI: 0.77-1.75, respectively) and adjusted analyses (RR = 1.42; 95% CI: 0.85-2.38; and RR = 1.03; 95% CI: 0.65-1.63, respectively). CONCLUSION: In this cohort, high caffeine intake was lower than in other studies and no association with LBW or preterm birth was found. Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.
OBJECTIVE: To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010. METHODS: Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. The women answered standardized questionnaires about reproductive health, prenatal care, life habits, sociodemographic conditions, and information about coffee intake. The independent variable was high caffeine consumption (≥300 mg/day) from coffee during pregnancy, and the dependent variables were LBW (birth weight < 2,500 g) and preterm birth (< 37 weeks of gestational age). Four adjusted polytomous logistic regression models, relative risk (RR) and 95% confidence interval (CI) were fitted: biological and sociodemographic conditions; obstetric history; current gestational conditions; and all variables included in the previous models. RESULTS: A total of 4,908 (64.5%) mothers consumed caffeine, 143 (2.9%) of whom reported high consumption. High caffeine intake was significantly associated with reduced education and with the occupation of the head of the family, nonwhite skin color, not having a partner, higher parity, previous abortion and preterm birth, urinary tract infection, threatened abortion, alcohol consumption and smoking. No association was found between high caffeine consumption and LBW or preterm birth in both unadjusted (RR = 1.45; 95% CI: 0.91-2.32; and RR = 1.16; 95% CI: 0.77-1.75, respectively) and adjusted analyses (RR = 1.42; 95% CI: 0.85-2.38; and RR = 1.03; 95% CI: 0.65-1.63, respectively). CONCLUSION: In this cohort, high caffeine intake was lower than in other studies and no association with LBW or preterm birth was found. Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.
Authors: M R Alcorta-García; C N López-Villaseñor; G Sánchez-Ferrer; H Flores-Mendoza; F Castorena-Torres; M A Aguilar-Torres; C M Sepúlveda-Treviño; J A Hernández-Hernández; R C López-Sánchez; V J Lara-Díaz Journal: Mol Cell Pediatr Date: 2020-06-01
Authors: Anni Lehtonen; Lauri Uusitalo; Seppo Auriola; Katri Backman; Seppo Heinonen; Leea Keski-Nisula; Markku Pasanen; Juha Pekkanen; Tomi-Pekka Tuomainen; Raimo Voutilainen; Sari Hantunen; Marko Lehtonen Journal: Eur J Nutr Date: 2020-04-03 Impact factor: 5.614