Literature DB >> 30535930

Approaches to Deprescribing Psychotropic Medications for Changed Behaviours in Long-Term Care Residents Living with Dementia.

Stephanie L Harrison1,2,3, Monica Cations4,5, Tiffany Jessop6, Sarah N Hilmer4,7, Mouna Sawan4, Henry Brodaty6,8,9.   

Abstract

Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings. This narrative review describes the current evidence regarding deprescribing psychotropic medications for people with dementia in long-term care. Deprescribing psychotropic medications can be achieved without harm to the person with dementia, and most people experience no withdrawal symptoms. Interventions to deprescribe psychotropic medications should be multifactorial, including lowering the dose of the medication over time, educational interventions and psychological support. However, implementing this is a significant challenge due to the overreliance on psychotropic medications for behavioural management in long-term aged care. Facilitators to deprescribing psychotropic medications in long-term care include multidisciplinary teams with adequate training, education and managerial support, engaging residents and families and change 'champions'. Deprescribing practices should be person-centred, and an individualised deprescribing protocol should be in place, followed by careful monitoring of the individual. The person with dementia and their family, general practitioner, pharmacist, and allied health and direct care staff should all be involved throughout the deprescribing process. Direct care staff need adequate support, education and training, so they can effectively help the individual and implement person-centred approaches in the absence of psychotropic medications. Effective communication between residents and staff and amongst staff is consistently shown to be an important factor for deciding whether deprescribing of a medication should occur and the successful implementation of deprescribing psychotropic medications.

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Year:  2019        PMID: 30535930     DOI: 10.1007/s40266-018-0623-6

Source DB:  PubMed          Journal:  Drugs Aging        ISSN: 1170-229X            Impact factor:   3.923


  105 in total

1.  Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses.

Authors:  Rajesh R Tampi; Deena J Tampi; Silpa Balachandran; Shilpa Srinivasan
Journal:  Ther Adv Chronic Dis       Date:  2016-07-15       Impact factor: 5.091

Review 2.  Risk versus risk: a review of benzodiazepine reduction in older adults.

Authors:  Allison M Paquin; Kristin Zimmerman; James L Rudolph
Journal:  Expert Opin Drug Saf       Date:  2014-06-06       Impact factor: 4.250

3.  Animal-Assisted Intervention and Dementia: A Systematic Review.

Authors:  Michelle L Yakimicki; Nancy E Edwards; Elizabeth Richards; Alan M Beck
Journal:  Clin Nurs Res       Date:  2018-02-14       Impact factor: 2.075

Review 4.  A systematic review of interventions to deprescribe benzodiazepines and other hypnotics among older people.

Authors:  Emily Reeve; Magdalene Ong; Angela Wu; Jesse Jansen; Mirko Petrovic; Danijela Gnjidic
Journal:  Eur J Clin Pharmacol       Date:  2017-04-30       Impact factor: 2.953

5.  Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: a cluster-randomised trial.

Authors:  Lynn Chenoweth; Madeleine T King; Yun-Hee Jeon; Henry Brodaty; Jane Stein-Parbury; Richard Norman; Marion Haas; Georgina Luscombe
Journal:  Lancet Neurol       Date:  2009-03-11       Impact factor: 44.182

6.  The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial.

Authors:  Clive Ballard; Maria Luisa Hanney; Megan Theodoulou; Simon Douglas; Rupert McShane; Katja Kossakowski; Randeep Gill; Edmund Juszczak; Ly-Mee Yu; Robin Jacoby
Journal:  Lancet Neurol       Date:  2009-01-08       Impact factor: 44.182

7.  Unexplained variation across US nursing homes in antipsychotic prescribing rates.

Authors:  Yong Chen; Becky A Briesacher; Terry S Field; Jennifer Tjia; Denys T Lau; Jerry H Gurwitz
Journal:  Arch Intern Med       Date:  2010-01-11

8.  Behavioral and psychological symptoms and psychotropic drugs among people with cognitive impairment in nursing homes in 2007 and 2013.

Authors:  Maria Gustafsson; Ulf Isaksson; Stig Karlsson; Per-Olof Sandman; Hugo Lövheim
Journal:  Eur J Clin Pharmacol       Date:  2016-04-13       Impact factor: 2.953

Review 9.  Reminiscence therapy for dementia.

Authors:  Bob Woods; Laura O'Philbin; Emma M Farrell; Aimee E Spector; Martin Orrell
Journal:  Cochrane Database Syst Rev       Date:  2018-03-01

Review 10.  Assessment and management of behavioral and psychological symptoms of dementia.

Authors:  Helen C Kales; Laura N Gitlin; Constantine G Lyketsos
Journal:  BMJ       Date:  2015-03-02
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  12 in total

1.  Attitudes toward deprescribing among older adults with dementia in the United States.

Authors:  Matthew E Growdon; Edie Espejo; Bocheng Jing; W John Boscardin; Andrew R Zullo; Kristine Yaffe; Kenneth S Boockvar; Michael A Steinman
Journal:  J Am Geriatr Soc       Date:  2022-03-10       Impact factor: 7.538

2.  As-Needed Prescribing and Administration of Psychotropic Medications in Assisted Living: A 7-State Study.

Authors:  Paula Carder; Sheryl Zimmerman; Christopher J Wretman; John S Preisser; Sarah Dys; Philip D Sloane
Journal:  J Am Med Dir Assoc       Date:  2021-12-14       Impact factor: 7.802

3.  Syndrome-Based Prescription to Optimize Psychotropics: Are CHROME Criteria a Game Changer?

Authors:  Ruben Muñiz; Jorge López-Alvarez; Luis Agüera-Ortiz; Luis Perea; Javier Olazarán
Journal:  Front Psychiatry       Date:  2021-04-22       Impact factor: 4.157

Review 4.  Interventions to optimize medication use in nursing homes: a narrative review.

Authors:  Anne Spinewine; Perrine Evrard; Carmel Hughes
Journal:  Eur Geriatr Med       Date:  2021-03-09       Impact factor: 1.710

Review 5.  Depression, antidepressants and fall risk: therapeutic dilemmas-a clinical review.

Authors:  E P van Poelgeest; A C Pronk; D Rhebergen; N van der Velde
Journal:  Eur Geriatr Med       Date:  2021-03-15       Impact factor: 1.710

6.  Potentially Inappropriate Medications in a Psychogeriatric Inpatient Ward: An Audit Based on Beers Criteria.

Authors:  Isabelle Moebs; Esther Abeln; Annalise Siefert; Yoram Barak
Journal:  Neurol Ther       Date:  2020-04-17

7.  Initiation of antipsychotics after moving to residential aged care facilities and mortality: a national cohort study.

Authors:  Stephanie L Harrison; Janet K Sluggett; Catherine Lang; Craig Whitehead; Maria Crotty; Megan Corlis; Steve Wesselingh; Maria C Inacio
Journal:  Aging Clin Exp Res       Date:  2020-03-11       Impact factor: 3.636

8.  Prevalence and Associated Factors of Polypharmacy in Nursing Home Residents: A Cross-Sectional Study.

Authors:  Raquel Cadenas; María José Diez; Nélida Fernández; Juan José García; Ana M Sahagún; Matilde Sierra; Cristina López; Julen Susperregui; Raquel Díez
Journal:  Int J Environ Res Public Health       Date:  2021-02-19       Impact factor: 3.390

9.  CHROME Criteria and Quality of Life: A Pilot Study from Maria Wolff-Albertia.

Authors:  Ruben Muñiz; Jorge López-Álvarez; Luis Perea; Sofía Rivera; Liliana González; Javier Olazarán
Journal:  J Alzheimers Dis Rep       Date:  2021-08-06

10.  What Makes Deprescription of Psychotropic Drugs in Nursing Home Residents with Dementia so Challenging? A Qualitative Systematic Review of Barriers and Facilitators.

Authors:  Amalie Elisabeth Moth; Pernille Hølmkjær; Anne Holm; Maarten Pieter Rozing; Gritt Overbeck
Journal:  Drugs Aging       Date:  2021-07-07       Impact factor: 3.923

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