Late in-stent restenosis after sirolimus-eluting stent implantation is related to thrombus formation-Insight from a case with IVUS, OCT, and histological findings.

We experienced a case of very late in-stent restenosis of a sirolimus-eluting stent (SES) (3.0 mm × 18 mm) in the left anterior descending coronary artery in a 62-year-old man with type 2 diabetes mellitus, dyslipidemia, and hypertension. Angina pectoris recurred 39 months after the index percutaneous coronary intervention (PCI). We performed PCI with optical coherence tomography (OCT) and intravascular ultrasound (IVUS) guidance. OCT showed very eccentric low signal plaque with a high signal thin cap on the delayed healing stent struts without intimal coverage. IVUS showed that the plaque was eccentric and hypoechogenic with a "black hole appearance." We used a filter wire (Filtrap™, Nipro, Osaka, Japan) to prevent distal embolism. Filter no-reflow occurred after predilatation. We deployed a paclitaxel-eluting stent followed by postdilatation. After aspiration and Filtrap™ withdrawal, thrombolysis in myocardial infarction 3 flow was obtained. Histopathological analysis revealed that the main tissue was composed of fibrin deposits with scarce inflammatory cells and proteoglycans. This case revealed that fibrin formation is related to very late in-stent restenosis and OCT and IVUS characteristics of this case are shown.