Mauricio E Gamez1, Ryan Kraus2, Michael L Hinni3, Eric J Moore4, Daniel J Ma5, Stephen J Ko6, Jean Claude M Rwigema1, Lisa A McGee1, Michele Y Halyard1, Matthew R Buras7, Robert L Foote5, Samir H Patel8. 1. Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, AZ, United States. 2. University of Southern California Keck School of Medicine, Los Angeles, CA, United States. 3. Department of Otolaryngology-Head and Neck Surgery/Audiology, Mayo Clinic Hospital, Phoenix, AZ, United States. 4. Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, United States. 5. Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States. 6. Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United States. 7. Biostatistics, Mayo Clinic, Scottsdale, AZ, United States. 8. Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, AZ, United States. Electronic address: patel.samir@mayo.edu.
Abstract
OBJECTIVES: The natural history of squamous cell carcinoma (SCC) of the oral cavity (OC) in young adults is unknown. We sought to provide an updated report on treatment outcomes of patients with OC SCC who were 40 years or younger. MATERIALS AND METHODS: We performed a retrospective analysis of 124 consecutive patients with primary OC SCC treated at Mayo Clinic (1980-2014). Patient and tumor characteristics and treatment approach were abstracted from patient charts. RESULTS: Median patient age was 35 years (range, 19-40 years). The most common primary site was oral tongue (107 patients; 86.3%). Most patients (101; 81.5%) underwent wide local excision. Surgery alone was curative in 77 patients (62.1%); 47 (37.9%) received radiotherapy, and 26 (21%) received chemotherapy. Five-year overall survival (OS) was 78.1%; 10-year OS was 76.9%. Five-year disease-free survival (DFS) was 66.6%; 5-year local control was 87.6%; and 5-year locoregional control was 78.5%. On multivariable analysis, factors associated with worse OS and DFS were higher pathologic T stage (P = .008), lymph node positivity (P < .001), and disease recurrence (P < .001). CONCLUSION: Young adults with primary OC SCC may be treated with a similar treatment approach as older adults.
OBJECTIVES: The natural history of squamous cell carcinoma (SCC) of the oral cavity (OC) in young adults is unknown. We sought to provide an updated report on treatment outcomes of patients with OC SCC who were 40 years or younger. MATERIALS AND METHODS: We performed a retrospective analysis of 124 consecutive patients with primary OC SCC treated at Mayo Clinic (1980-2014). Patient and tumor characteristics and treatment approach were abstracted from patient charts. RESULTS: Median patient age was 35 years (range, 19-40 years). The most common primary site was oral tongue (107 patients; 86.3%). Most patients (101; 81.5%) underwent wide local excision. Surgery alone was curative in 77 patients (62.1%); 47 (37.9%) received radiotherapy, and 26 (21%) received chemotherapy. Five-year overall survival (OS) was 78.1%; 10-year OS was 76.9%. Five-year disease-free survival (DFS) was 66.6%; 5-year local control was 87.6%; and 5-year locoregional control was 78.5%. On multivariable analysis, factors associated with worse OS and DFS were higher pathologic T stage (P = .008), lymph node positivity (P < .001), and disease recurrence (P < .001). CONCLUSION: Young adults with primary OC SCC may be treated with a similar treatment approach as older adults.
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Authors: Wadad S Mneimneh; Bin Xu; Charles Ghossein; Bayan Alzumaili; Shenon Sethi; Ian Ganly; Anjanie Khimraj; Snjezana Dogan; Nora Katabi Journal: Head Neck Pathol Date: 2021-04-02
Authors: Kyriakos Chatzopoulos; Sotiris Sotiriou; Andrea R Collins; Panagiotis Kartsidis; Alessandra C Schmitt; Xianfeng Chen; Khashayarsha Khazaie; Michael L Hinni; Colleen A Ramsower; Matthew A Zarka; Samir H Patel; Joaquin J Garcia Journal: Head Neck Pathol Date: 2020-10-03