Literature DB >> 30525100

TRIM16 controls turnover of protein aggregates by modulating NRF2, ubiquitin system, and autophagy: implication for tumorigenesis.

Kautilya Kumar Jena1,2, Srinivasa Prasad Kolapalli1, Subhash Mehto1, Swati Chauhan1, Santosh Chauhan1.   

Abstract

Protein misfolding and protein aggregation are linked to several diseases commonly called as proteinopathies, which include cancer. Understanding the mechanisms of proteostasis could provide newer strategies to combat proteinopathies. We have recently demonstrated a new mechanism where we found that TRIM16 (tripartite motif-containing protein 16) utilizing NRF2-p62 axis and autophagy streamlines the safe disposal of misfolded proteins to maintain protein homeostasis.

Entities:  

Keywords:  NRF2/NFE2L2; TRIM16; aggrephagy; autophagy. Protein aggregates; cancer; oxidative stress; p62/SQSTM1; protein homeostasis; protein quality control; proteotoxic stress

Year:  2018        PMID： 30525100      PMCID： PMC6276851          DOI： 10.1080/23723556.2018.1532251

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.

Authors:  Dan T Vogl; Edward A Stadtmauer; Kay-See Tan; Daniel F Heitjan; Lisa E Davis; Laura Pontiggia; Reshma Rangwala; Shengfu Piao; Yunyoung C Chang; Emma C Scott; Thomas M Paul; Charles W Nichols; David L Porter; Janeen Kaplan; Gayle Mallon; James E Bradner; Ravi K Amaravadi
Journal:  Autophagy       Date:  2014-05-20       Impact factor: 16.016

2.  TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

Authors:  Michael A Mandell; Ashish Jain; John Arko-Mensah; Santosh Chauhan; Tomonori Kimura; Christina Dinkins; Guido Silvestri; Jan Münch; Frank Kirchhoff; Anne Simonsen; Yongjie Wei; Beth Levine; Terje Johansen; Vojo Deretic
Journal:  Dev Cell       Date:  2014-08-07       Impact factor: 12.270

3.  Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.

Authors:  Jie Xu; Joke Reumers; José R Couceiro; Frederik De Smet; Rodrigo Gallardo; Stanislav Rudyak; Ann Cornelis; Jef Rozenski; Aleksandra Zwolinska; Jean-Christophe Marine; Diether Lambrechts; Young-Ah Suh; Frederic Rousseau; Joost Schymkowitz
Journal:  Nat Chem Biol       Date:  2011-03-27       Impact factor: 15.040

4.  Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis.

Authors:  Liang Chen; Michael D Brewer; Lili Guo; Ruoxing Wang; Peng Jiang; Xiaolu Yang
Journal:  Cell Rep       Date:  2017-03-28       Impact factor: 9.423

5.  TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

Authors:  Santosh Chauhan; Suresh Kumar; Ashish Jain; Marisa Ponpuak; Michal H Mudd; Tomonori Kimura; Seong Won Choi; Ryan Peters; Michael Mandell; Jack-Ansgar Bruun; Terje Johansen; Vojo Deretic
Journal:  Dev Cell       Date:  2016-09-29       Impact factor: 12.270

Review 6.  Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

Authors:  Paul J Muchowski
Journal:  Neuron       Date:  2002-07-03       Impact factor: 17.173

Review 7.  Misfolded proteins: from little villains to little helpers in the fight against cancer.

Authors:  Ansgar Brüning; Julia Jückstock
Journal:  Front Oncol       Date:  2015-02-24       Impact factor: 6.244

Review 8.  Recent insights into the function of autophagy in cancer.

Authors:  Ravi Amaravadi; Alec C Kimmelman; Eileen White
Journal:  Genes Dev       Date:  2016-09-01       Impact factor: 11.361

9.  Oncogenic addiction to high 26S proteasome level.

Authors:  Peter Tsvetkov; Julia Adler; Nadav Myers; Assaf Biran; Nina Reuven; Yosef Shaul
Journal:  Cell Death Dis       Date:  2018-07-10       Impact factor: 8.469

10.  TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.

Authors:  Kautilya Kumar Jena; Srinivasa Prasad Kolapalli; Subhash Mehto; Parej Nath; Biswajit Das; Pradyumna Kumar Sahoo; Abdul Ahad; Gulam Hussain Syed; Sunil K Raghav; Shantibhusan Senapati; Swati Chauhan; Santosh Chauhan
Journal:  EMBO J       Date:  2018-08-24       Impact factor: 11.598
  10 in total
  2 in total

1.  TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.

Authors:  Katrine Stange Overå; Juncal Garcia-Garcia; Zambarlal Bhujabal; Ashish Jain; Aud Øvervatn; Kenneth Bowitz Larsen; Vojo Deretic; Terje Johansen; Trond Lamark; Eva Sjøttem
Journal:  J Cell Sci       Date:  2019-12-02       Impact factor: 5.285

2.  TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.

Authors:  Lin Lyu; Zheng Chen; Nami McCarty
Journal:  Autophagy       Date:  2021-08-12       Impact factor: 13.391
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.