Phosphino-Triazole Ligands for Palladium-Catalyzed Cross-Coupling.

Twelve 1,5-disubtituted and fourteen 5-substituted 1,2,3-triazole derivatives bearing diaryl or dialkyl phosphines at the 5-position were synthesized and used as ligands for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. Bulky substrates were tested, and lead-like product formation was demonstrated. The online tool SambVca2.0 was used to assess steric parameters of ligands and preliminary buried volume determination using XRD-obtained data in a small number of cases proved to be informative. Two modeling approaches were compared for the determination of the buried volume of ligands where XRD data was not available. An approach with imposed steric restrictions was found to be superior in leading to buried volume determinations that closely correlate with observed reaction conversions. The online tool LLAMA was used to determine lead-likeness of potential Suzuki-Miyaura cross-coupling products, from which 10 of the most lead-like were successfully synthesized. Thus, confirming these readily accessible triazole-containing phosphines as highly suitable ligands for reaction screening and optimization in drug discovery campaigns.

Introduction

Click chemistry, as defined by Sharpless and co-workers,[1−4] has transformed the face, and accessibility to the nonspecialist of moleclass="Chemical">cular linking strategies. Among click aclass="Chemical">pclass="Chemical">proaches, the highly regioselective class="Chemical">pan class="Chemical">copper-catalyzed, Huisgen cycloaddition reaction to form 1,4-triazoles (Figure , 1) by Meldal and Sharpless,[4,5] has grown in popularity and has been employed in increasingly varied applications over the intervening years.[6] The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is ubiquitous,[5,7−9] and often referred to as “the click reaction”, and the product 1,2,3-triazoles, bearing 1,4-substition patterns, with reliable fidelity and yields being synonymous with click chemistry (Figure , 1).[8,10−15] However, the resulting triazoles are not always employed as innocent bystander linkage motifs. Triazoles of this type have been used as analogues of peptide linkages (Figure , 2),[16] such peptidomimetics are physiologically stable, and their modular synthesis allows access to a broad range of biologically relevant applications.[17,18] The utility of further synthetic transformations has been probed, particularly in the derivatization at the 5-position (Figure , 3).[19,20]

Figure 1

Upper: copper-catalyzed azide–alkyne cycloaddition (CuAAC). Lower: examples of 1,2,3-triazole-containing structures.

Upper: class="Chemical">copper-catalyzed class="Chemical">pan class="Chemical">azide–alkyne cycloaddition (CuAAC). Lower: examples of 1,2,3-triazole-containing structures.

class="Chemical">Copper-catalyzed class="Chemical">pan class="Chemical">triazole formation has been exploited in a wide range of scenarios[21] and has been the subject of various mechanistic studies,[22−26] leading to the proposal of a binuclear transition state involving two copper atoms. 1,2,3-Triazole derivatives have been employed as nitrogen-coordinating ligands,[27] e.g. in N,N′-,[28−34] N,S-,[29] N,Se-[29] and cyclometalated[35−37] bidentate coordination complexes. Furthermore, tris-triazoles, such as TBTA (Figure , 4) and its analogues, have been used as ligands for reactions including the CuAAC by both Fokin[38] and Zhu[39] and their co-workers, demonstrating exceptional ligand-mediated reaction acceleration.

Figure 2

Examples of triazole-containing or -derived ligands.

Examples of pan class="Chemical">triazole-containing or -derived ligands.

Alkylation of a class="Chemical">1,2,3-triazole derivative, to furnish a class="Chemical">pan class="Chemical">1,3,4-trisubstituted triazolium salt, is the first step in the synthesis of a newer class of N-heterocyclic carbene (NHC) reported in 2008 by Albrecht and co-workers[40] and later extended by Lee and Crowley[41−43] as ligands for gold and by Grubbs and Bertrand as ligands for ruthenium-mediated catalysis (Figure , 5).[44] The ready access to a range of ligand scaffolds through the CuAAC has led the triazole–NHC platform to continue to gain in popularity.[45−49] These reports demonstrate the 1,2,3-triazole unit is a legitimate candidate for further exploitation as a key component in ligand design and catalyst development.[50]

The co-authors of this report have investigated class="Chemical">triazoles as chemosensors[51−53] and as class="Chemical">products of asymmetric synthesis.[54−58] Furthermore, an interest in class="Chemical">pan class="Chemical">boronic acid derivatives as chemosensors,[59−64] including the use of cross-coupling reactions as a means of sensing,[65] means the co-authors of this report are familiar with boronic acids and esters.[66] As such, a desire to bring together these streams of research under one umbrella has led to the research reported in this manuscript. Herein, the development of bulky and highly active triazole-containing phosphine ligands for palladium-catalyzed Suzuki–Miyaura cross-coupling reactions is explored (Scheme ).

Scheme 1

Outline of a General Palladium-Catalyzed Suzuki–Miyaura Formation of Biaryl 6

class="Chemical">Palladium-catalyzed cross-couclass="Chemical">pling reactions are well-studied and offer ready access to an extensive range of (bi)aryl motifs (Scheme , 6).[67−76] The suite of class="Chemical">pan class="Chemical">palladium-catalyzed cross-coupling chemistry available for the construction of biologically relevant products has transformed the field of medicinal chemistry, yet cross-coupling between sterically hindered and lead-like building blocks, particularly with aryl chlorides, remains challenging.[77]

Developments in class="Chemical">palladium-catalyzed chemistry have been heavily influenced by ligand design and oclass="Chemical">ptimization. Among the suclass="Chemical">perior ligands for class="Chemical">pan class="Chemical">palladium-catalyzed cross-coupling reactions are bulky alkyl phosphines,[78−82] and bulky ortho-substituted aryl-alkyl phosphines,[83,84] such as S-Phos (Figure , 7)[85] and X-Phos (Figure , 8).[86] Metallocyclic precatalysts have been developed which delivered greater stability, more facile manipulation and enhanced reaction outcomes.[87−89]

Figure 3

Representative examples of bulky phosphine ligands including: upper: S-Phos (7) and X-Phos (8); middle left: heteroaromatic phosphine derivative (9); middle right and lower row: Phosphino-ferrocene derivatives displaying planar chirality.

Representative examples of bulky class="Chemical">phosphine ligands including: uclass="Chemical">pclass="Chemical">per: class="Chemical">pan class="Chemical">S-Phos (7) and X-Phos (8); middle left: heteroaromatic phosphine derivative (9); middle right and lower row: Phosphino-ferrocene derivatives displaying planar chirality.

class="Chemical">Phosphines aclass="Chemical">pclass="Chemical">pended to one or more five-membered, all sclass="Chemical">p2 rings have been shown to offer advantages in some cases. The class="Chemical">pan class="Chemical">pyrrole-appended phosphines of Beller and co-workers (Figure , 9)[90,91] have proven to be useful ligands in cross-coupling catalysis that furnishes drug-like products. Furthermore, the bulky, electron-rich, ferrocene-appended phosphines of Richards (Figure , 10),[92] Johannsen (Figure , 11),[93] Fu (Figure , 12),[94] and their respective co-workers provide access to highly active palladium-ligand conjugates for cross-coupling some of the least active substrates.

class="Chemical">1,4-Disubstituted-1,2,3-triazoles have been used in the assembly of class="Chemical">pan class="Chemical">phosphorus-containing species that have the potential to be employed as ligands. Ready access to libraries of products using CuAAC reactions has permitted the development of phosphines connected to triazoles with sp3 linkages to the 1-N and 4-C positions. Examples include those reported by Dubrovnia, Börner and co-workers (Figure , 13),[95] Gandelman and co-workers who prepared PCP′ pincer complexes from bis-phosphinotriazoles (Figure , 14),[96] and Kann and co-workers who used a borane-protected P-chiral azide to deliver protected P-chiral triazole-containing phosphines (Figure , 15).[97] Since proximal stoichiometric phosphine can arrest the CuAAC through coordinative saturation of substoichiometic copper catalyst or unwanted Staudinger-type reactions between phosphine and azide derivative, alternative approaches are required to deliver P-appended triazoles. Zhang and co-workers reported on the use of alkynyl Grignard reagents for the synthesis of a phosphine series where phosphorus is attached directly to a 1,2,3-triazole ring at the 4-position (Figure , 16).[98−101] As part of an impressive, rigorous, and detailed study, Balakrishna and co-workers prepared not only expected aryl phosphine triazole derivative 17a (Figure ) through lithium-halogen exchange and subsequent reaction with diphenylphosphorus chloride on the corresponding bromide under kinetic control but also thermodynamically favored 5-phosphino triazole 18a (Figure ) from the same aryl bromide starting material under different conditions.[102] Fukuzawa and co-workers also employed deprotonation of the 5-position of a 1,2,3-triazole to facilitate installation of 5-phosphino functionality in their ferroncenyl bisphosphino ligand synthesis (Figure , 19).[103] Glover et al.[104] and Austeri et al.[105] also utilized deprotonation of the triazole 5-position to create planar chiral cyclophane-containing analogues of 18a. In order to successfully synthesize a bis-5-phosphino-triazole bidentate ligand, Manoury, Virieux, and co-workers employed an ethynyl phosphine oxide in their homocoupled dimer synthesis, which after treatment with trichlorosilane resulted in 20 (Figure ).[106] A structurally related 5–18 hybrid system was also recently reported by Cao et al., who showed the formation of bimetallic complexes of NHC–phosphine mixed systems.[107]

Figure 4

Phosphorus-containing 1,2,3-triazole derivatives.

pan class="Chemical">Phosphorus-containing class="Chemical">pan class="Chemical">1,2,3-triazole derivatives.

Bulky, or sterically hindered, class="Chemical">phosphorus-containing ligands have also found aclass="Chemical">pclass="Chemical">plication outside of the class="Chemical">pan class="Chemical">palladium catalysis arena; steric parameters appear to be important in a variety of gold-mediated transformations.[108−110] Steric and electronic parameters of phosphine ligands have been a subject of study for more than 40 years.[111] More recent contributions have built upon Tolman’s concept of cone angle as a descriptor of the steric bulk a ligand imparts about a metal, resulting in a parameter known as buried volume (%VBur) coming to the fore.[112] Cavallo and co-workers have developed a free web-based tool for the calculation of %VBur, named SambVca.[113] This parametrization of ligands, using both spectroscopic measurements and calculated properties (using principle component analysis for example), has facilitated exceptional ligand design and optimization across a range of catalyzed reactions.[114−116]

While a range of ligand-based solutions for cross-coupling reactions exist, a platform to rapidly deliver alternatives and explore chemical space around novel catalyst constructs, such as through pan class="Chemical">CuAAC, offers aclass="Chemical">pclass="Chemical">proaches and comclass="Chemical">plementary tools to the field. Furthermore, cross-couclass="Chemical">pling catalysis manifolds that class="Chemical">provide access to increasingly three-dimensional class="Chemical">products,[117] and those directly delivering class="Chemical">products with lead- or drug-like class="Chemical">proclass="Chemical">perties[118] without need of class="Chemical">protecting grouclass="Chemical">p removal or further derivatization are desired and less-well exclass="Chemical">plored.[77]

Results and Discussion

In order to overcome the general incompatibility of class="Chemical">phosphines with the class="Chemical">pan class="Chemical">CuAAC reaction, an approach other than direct phosphine incorporation is required. While protection of the phosphine (as a phosphine oxide for example)[106] is possible, the initial approach chosen in this program was to probe the potential for triazole-mediated directed ortho-lithiation or halogen-lithium exchange, and subsequent reaction with diphenyl phosphorus chloride, as possible routes to phosphino-triazoles 17a–c. Accordingly, 1,4-diphenyl-1,2,3-triazole (21a) was selected as a model substrate to test if ortho-lithiation could deliver the required intermediate to give the desired product 17a. As such, 21a was reacted at −78 °C with n-butyllithium, followed by addition of the phosphorus chloride reagent, before being allowed to warm to room temperature, and being allowed to stir for a period of time. Over numerous attempts only the unanticipated product 18a was isolated from such reactions, Scheme . This indicates that deprotonation of the 5-position of the triazole is facile, resulting in formation of the observed major product. In order to mitigate against the formation of unanticipated triazole-phosphine 18a, brominated triazole derivatives 22a–c were employed under a similar protocol, with varying amounts of n-butyllithium. In all cases, the same 5-phosphino-triazole product, 18a, was obtained, shown in Scheme . In the case of 22a, it was possible to isolate small quantities of the desired product 17a. X-ray crystal structures of both 17a and 18a were determined as shown in Figure .

Scheme 2

Reaction of 1,2,3-Triazoles 21a–d with n-Butyllithium Followed by Treatment with Diphenyl Phosphorous Chloride Led Primarily to Formation of Phosphino-Triazole 18a

Figure 5

Representation of the crystal structures of isomeric 17a (left) and 18a (right), ellipsoids drawn at the 50% probability level (Ortep3 for Windows and PovRay). For 17a the structure contains two crystallographically independent molecules with only one shown for clarity. For 18a the phenyl-appended 1-nitrogen and 4-carbon atoms of the triazole unit are disordered such that the triazole ring occupies two opposing orientations, related by a 180° rotation of the triazole ring about the phosphorus-triazole bond. The refined percentage occupancy ratio of the two positions are 59.7 (15) and 40.3 (15); one arbitrary molecule depicted and hydrogen atoms removed for clarity.

Representation of the crystal structures of isomeric 17a (left) and 18a (right), ellipsoids drawn at the 50% probability level (Ortep3 for Windows and PovRay). For 17a the structure contains two crystallographically independent moleclass="Chemical">cules with only one shown for clarity. For 18a the class="Chemical">phenyl-aclass="Chemical">pclass="Chemical">pended class="Chemical">pan class="Chemical">1-nitrogen and 4-carbon atoms of the triazole unit are disordered such that the triazole ring occupies two opposing orientations, related by a 180° rotation of the triazole ring about the phosphorus-triazole bond. The refined percentage occupancy ratio of the two positions are 59.7 (15) and 40.3 (15); one arbitrary molecule depicted and hydrogen atoms removed for clarity.

In fact these observations should not have been at all unanticipated.[102,104] The aforementioned report of Balakrishna and co-workers had previously probed the reaction of 17a in more detail than us under analogous conditions[102] and determined a “kinetic” and “thermodynamic” relationship between class="Chemical">lithium-class="Chemical">pan class="Chemical">halogen exchange alone, versus lithium-halogen exchange followed by lithium (triazole-) proton exchange leading to products 17a and 18a respectively, Scheme .

Scheme 3

Previously Reported Kinetic (Upper) and Thermodynamic (Lower) Lithiation and Subsequent Phosphorous Addition to Brominated Triazole 22a Affording P-Aryl and P-Triazole Derivatives, Respectively

Ref (102).

Attempts to block the class="Chemical">triazole 5-H class="Chemical">position, using the class="Chemical">pan class="Chemical">deuterium masking approach deployed by Richards and co-workers in the preparation of ferrocene derivatives,[119] did not dramatically modify reaction outcomes in our hands. Variously deuterated products were always obtained from attempted lithiation-mediated access to products under routine conditions.

Since the scope of 18a-like ligands had not been investigated beyond the three class="Chemical">triazole backbones reclass="Chemical">ported by Glover et al.[104] and Choubey et al.,[102] we chose to foclass="Chemical">pan class="Chemical">cus attention on triazole 5-H lithiation to deliver a range of potential ligands for cross-coupling catalysis. To this end, alkynes 23a and 23b reacted smoothly with azides 24a–f to furnish 1,5-disubstituted 1,2,3-triazoles 21a–i in acceptable to good yields, shown in Scheme .

Scheme 4

CuAAC Reaction to Form 1,4-Disubstituted 1,2,3-Triazole Derivatives 21a–i

Applying the aforementioned class="Chemical">triazole lithiation and subsequent quench with dicyclohexyl-, di-iso-class="Chemical">proclass="Chemical">pyl-, or diclass="Chemical">phenyl- class="Chemical">pan class="Chemical">phosphorus chloride reagent protocol to isolated 21a–i triazole set, with the express expectation of generating 5-phosphino triazole derivatives, delivered 12 targeted phosphino-triazoles 18a–l in acceptable to good yields (Scheme ).

Scheme 5

Deprotonation and Subsequent Reaction with Phosphorous Chloride Reagent Protocol for Delivery of 18a–l

In order to benchmark the catalytic capability of ligands in this report, the class="Chemical">palladium-catalyzed Suzuki–Miyaura reaction of class="Chemical">pan class="Chemical">2-bromo-m-xylene (25) and ortho-tolylboronic acid (26) under standard conditions (1 mol % palladium, 2 mol % ligand, three equivalents of base, 10 h, toluene, 90 °C, see the Supporting Information) was compared. The catalyzed formation of compound 27 represents a challenging but achievable cross-coupling: While an aryl bromide is employed in the reaction, the product (a triply ortho-substituted biaryl) is sterically congested about the formed bond. Diphenyl aryl phosphine 17a and 5-phosphino triazoles 18a–l were employed as ligands in the benchmark reaction (Table ). The use of 17a as ligand (Table , entry 1) resulted in 29% conversion to product 27. The 5-phosphino isomer of 17a, 18a, also gave less than 50% conversion to desired product 27 in the same reaction (Table , entry 2). As may be expected, switching the diphenylphosphine part of 18a to dialkylphosphine groups di-iso-propyl (18b) and dicyclohexyl (18c) improved the reaction outcomes, resulting in 62 and 75% conversion, respectively (Table , entries 3 and 4). Changing the alkyne-derived part of the triazole from phenyl (18a) to cyclohexyl (18d) gave a marked improvement delivering product 27 in 86% conversion (Table , entry 2 versus 5).

Table 1

Ligand Screening: 1,4-Disubstituted 1,2,3-Triazole-Containing Phosphine Ligand Mediate, Palladium-Catalyzed, Formation of 27a

entry	R1	R2	R3	ligand	conversion [%]b
1				17a	29
2	Ph	H	Ph	18a	47
3	Ph	H	i-Pr	18b	62
4	Ph	H	Cy	18c	75
5	Cy	H	Ph	18d	86
6	Ph	4-Me	Ph	18e	69
7	Ph	4-OMe	Ph	18f	83
8	Ph	2,6-OMe	Ph	18g	92
9	Cy	2,6-OMe	Ph	18h	90
10	Ph	2-Ph	Ph	18i	84
11	Ph	2-Ph	Cy	18j	92
12	Ph	2-Napthe	Ph	18k	91
13	Cy	2-Napthe	Ph	18l	99

Reaction conditions: 2-bromo-m-xylene (0.4 mmol), o-tolylboronic acid (0.6 mmol), potassium phosphate (1.2 mmol), Pd2(dba)3 (0.5 mol %), ligand (2 mol %), toluene (3 mL), 10 h, 90 °C.

Conversion determined by inspection of the corresponding 1H NMR spectra of crude reaction isolates. See the Supporting Information for details.

Meaning derived from naphthyl azide.

Reaction conditions: class="Chemical">2-bromo-m-xylene (0.4 mmol), class="Chemical">pan class="Chemical">o-tolylboronic acid (0.6 mmol), potassium phosphate (1.2 mmol), Pd2(dba)3 (0.5 mol %), ligand (2 mol %), toluene (3 mL), 10 h, 90 °C.

Conversion determined by inspection of the corresponding pan class="Chemical">1H NMR sclass="Chemical">pectra of crude reaction isolates. See the Suclass="Chemical">pclass="Chemical">porting Information for details.

Meaning derived from naphthyl pan class="Chemical">azide.

While good results were obtained in the Suzuki–Miyaura cross-coupling reactions with 18-derived catalysts the more effective ligands (generally larger) suffered somewhat from poor solubility. Thus, ligand modifications that retained activity but allowed for more ready synthesis and manipulation at larger scale were sought. From briefly surveying the results in Table it was concluded that changes in the R1 (class="Chemical">alkyne-derived) class="Chemical">part (e.g., entry 8 versus entry 9) were less influential on the reaction outcome than changes in the R2 (class="Chemical">pan class="Chemical">azide-derived) part (e.g., entry 5 versus entry 13). Reasoning that smaller ligands may benefit from enhanced solubility and tractability, a strategy to retain the N-substituents (azide-derived parts) while minimizing the alkyne-derived parts was chosen for further elaboration. Gevorgyan and co-workers have already reported that 1,5-disubstituted 1,2,3-triazoles may be accessed by selective reaction at the 5-position of 1-substituted triazoles (Figure shows the electrostatic potentials of the triazole-carbons they determined), and coupled with the synthetic strategies reported by Oki et al.[103] for chiral bisphosphine synthesis, this led to the conclusion that 1-substitutued triazoles may be readily converted to a library of 1-substituted, 5-phosphino 1,2,3-triazoles

Figure 6

Electrostatic potential charges as determined by Gevorgyan and co-workers,[19] indicates rationale for selective C-5 deprotonation.

Following the optimized protocol of Oki et al.[103] deployed in the synthesis of more complex constructs, a range of class="Chemical">1-substituted triazoles were synthesized. Sclass="Chemical">pecifically, class="Chemical">pan class="Chemical">trimethylsilylacetylene (23c) and aryl azides (24a–i) were exposed to CuAAC reaction conditions (Scheme ) that led to effective triazole formation and desilylation in one pot. Acceptable to good yields of 1-substituted triazoles 28a–i were isolated after 24 h room temperature reactions.

Scheme 6

Trimethylsilylacetylene (23c) and Aryl Azides (24a–i) React under Desilylative CuAAC Reaction Conditions to Deliver 1-Substituted 1,2,3-Triazoles (28a–i)

class="Chemical">Triazoles 28a–i reacted smoothly under the declass="Chemical">protonation and class="Chemical">pan class="Chemical">phosphorus chloride reagent quench reaction conditions described earlier. Deprotonation at −78 °C, by treatment with n-butyllithium, followed by addition of dicyclohexyl-, di-iso-propyl-, di-tert-butyl- or diphenyl-phosphorus chloride at the same temperature (Scheme ) resulted in formation of the desired triazole-containing phosphines 29a–n in acceptable to good yields. The X-ray crystal structure of 29g was determined (Figure ); the orientation of the molecule (in the solid state) is such that the lone pair of the phosphine is oriented to the same direction as the 1-aryl substituent of the triazole. In turn, this orientation about a central five-membered ring describes a relatively wide binding pocket for metals with potential for arene-metal interactions alongside primary phosphorus–metal ligation.

Scheme 7

Deprotonation of 1-Aryl 1,2,3-Triazole Derivatices and Subsequent Reaction with Phosphorous Chloride Reagent Protocol for Delivery of 29a–n

Figure 7

Representation of the crystal structure of 29g, ellipsoids drawn at the 50% probability level (Ortep3 for Windows and PovRay), hydrogen atoms omitted for clarity.

Representation of the crystal structure of 29g, ellipsoids drawn at the 50% probability level (Ortep3 for Windows and PovRay), pan class="Chemical">hydrogen atoms omitted for clarity.

Ligands 29a–n were tested in the aforementioned benchmark Suzuki–Miyaura cross-coupling reaction of 25 with 26 catalyzed by a class="Chemical">palladium–class="Chemical">pan class="Chemical">phosphine complex, to produce biaryl 27 (Table , entries 1–14). Under the same conditions, commercially sourced ligands, S-Phos (7) and X-Phos (8) were also used for comparison (Table , entries 15 and 16, respectively). Diphenyl-phosphino triazole derived ligands failed to deliver product 27 in good yields, under the conditions employed the best conversion for this ligand class was only 54% (ligand 29c, Table , entry 3), whereas dialkyl-phosphino triazoles gave universally excellent conversion, equal to the commercially sourced S- and X-Phos in performance, under these conditions.

Table 2

Ligand Screening: 1-Substituted 1,2,3-Triazole-Containing Phosphine Ligand Mediated, Palladium-Catalyzed, Reaction of Arylbromide 25 in the Formation of 27

entry	R1	R2	ligand	conversion [%]a,b
1	H	Ph	29a	20
2	H	Cy	29b	98
3	4-Me	Ph	29c	54
4	4-OMe	Ph	29d	28
5	2,6-OMe	Ph	29e	90
6	2,6-OMe	i-Pr	29f	99
7	2,6-OMe	Cy	29g	99
8	2,6-OMe	t-Bu	29h	98
9	2-Ph	Ph	29i	82
10	C4H4c	Ph	29j	29
11	4-CF3	Ph	29k	83
12	3,5-OMe	Ph	29l	51
13	2,6-i-Pr	Cy	29m	99
14	2,6-i-Pr	t-Bu	29n	99
15			S-Phos (7)	98
16			X-Phos (8)	99

Reaction conditions: 2-bromo-m-xylene (0.4 mmol), o-tolylboronic acid (0.6 mmol), potassium phosphate (1.2 mmol), Pd2(dba)3 (0.5 mol %), ligand (2.0 mol %), toluene (3 mL), 10 h, 90 °C.

Conversion determined by inspection of the corresponding 1H NMR spectra of crude reaction isolates. See the Supporting Information for details.

Derived from 2-naphthyl azide.

Reaction conditions: class="Chemical">2-bromo-m-xylene (0.4 mmol), class="Chemical">pan class="Chemical">o-tolylboronic acid (0.6 mmol), potassium phosphate (1.2 mmol), Pd2(dba)3 (0.5 mol %), ligand (2.0 mol %), toluene (3 mL), 10 h, 90 °C.

Conversion determined by inspection of the corresponding pan class="Chemical">1H NMR sclass="Chemical">pectra of crude reaction isolates. See the Suclass="Chemical">pclass="Chemical">porting Information for details.

Derived from pan class="Chemical">2-naphthyl azide.

While pleased to have created ligands offering good performance in a benchmark reaction, the reaction itself did not offer enough diversity of outcomes to evaluate dialkyl-class="Chemical">phosclass="Chemical">phino ligand class="Chemical">performances against each other nor against readily available commercial ligands 7 and 8. Next, a more sterically demanding test-reaction was chosen to evaluate the ligands further. The formation of class="Chemical">pan class="Chemical">biaryl C–C bonds where the formed bond is flanked by four ortho-substituents presents a particularly challenging yet attractive transformation, not in the least due to the apparent three-dimensional nature of the cross-coupled products.[117] The reaction of bromide 30 with boronic acid 31 was selected as one such reaction to probe catalyst effectiveness (Table ). Conversion to product 32 may be monitored by gas chromatographic analysis, facilitating ready comparison of reactions performed in parallel. Having given quantitative conversions to product 27 (Table , entries 7, 8, 13, and 14), and being both relatively easy to synthesize and available in sufficient quantities, ligands 29g, 29h, 29m, and 29n were selected for further investigation. These ligands are triazole-analogues of leading phenylene ligands 7 and 8; thus, in order to probe any specific advantages of triazole-core ligands they were compared directly against S-Phos and X-Phos phenylene ligands. (For retained and compared ligands, see Figure .)

Table 3

Ligand Screening: 1-Substituted 1,2,3-Triazole-Containing Phosphine Ligand Mediated, Palladium-Catalyzed, Reaction of Arylbromide 30 in Formation of 32

entry	ligand	conversion [%]a,b
1	29g	99
2	29gc	84
3	29h	47
4	29m	60
5	29n	13
6	S-Phos (7)	87
7	X-Phos (8)	50

Reaction conditions: 2-bromomesitylene (0.5 mmol), 2,6-xylylboronic acid (1.0 mmol), potassium phosphate (2 mmol), Pd2(dba)3 (2.0 mol %), ligand (8.0 mol %), toluene (3 mL), 18 h, reflux.

Determined by GC analysis with n-dodecane as internal standard.

Pd2(dba)3 (0.5 mol %), ligand (2 mol %).

Figure 8

Ligands compared in Table and Table .

Table 4

Ligand Screening: 1-Substituted 1,2,3-Triazole-Containing Phosphine Ligand-Mediated, Palladium-Catalyzed, Reaction of Arylchloride 37 in the Formation of 27

entry	ligand	conversion [%]a,b	isolated yield [%]
1	29g	99	93
2	29gc	99	92
3	29h	99	82
4	29m	99	92
5	29n	70
6	S-Phos (7)	33	25
7	X-Phos (8)	99	90

Reaction conditions: 2-chloro-m-xylene (1.0 mmol), o-tolyboronic acid (1.5 mmol), potassium phosphate (3.0 mmol), Pd2(dba)3 (0.5 mol %), ligand (2.0 mol %), toluene (3 mL), 10 h, 90 °C.

Determined by GC analysis with n-dodecane as internal standard.

Pd2(dba)3 (0.25 mol %), ligand (1.0 mol %).

Reaction conditions: class="Chemical">2-bromomesitylene (0.5 mmol), class="Chemical">pan class="Chemical">2,6-xylylboronic acid (1.0 mmol), potassium phosphate (2 mmol), Pd2(dba)3 (2.0 mol %), ligand (8.0 mol %), toluene (3 mL), 18 h, reflux.

Determined by GC analysis with pan class="Chemical">n-dodecane as internal standard.

pan class="Chemical">Pd2(dba)3 (0.5 mol %), ligand (2 mol %).

In order to ensure good reaction conversions, the catalyst loading, temperature, and reaction time were all increased in comparison to the earlier Suzuki–Miyaura reactions. The standard conditions employed in the comparisons of Table (entries 1 and 3–7) were 4 mol % class="Chemical">palladium and 8 mol % ligand in class="Chemical">pan class="Chemical">toluene at reflux for 16 h. Under these conditions, cyclohexyl-substituted triazole-containing ligands 29g and 29m gave higher conversions to 32 than did their tert-butyl-substituted analogues 29h and 29n (Table , entries 1 and 4 (99 and 60%) versus entries 3 and 5 (47 and 13%), respectively). In this comparison, the use of S-Phos (7) as ligand gave 87% conversion (Table , entry 6) and the use of X-Phos (8) as ligand gave 50% conversion (Table , entry 7) to compound 32 (under these conditions). Since ligand 29g gave the best conversion (under the conditions employed), catalyst loading was reduced to 1 mol % palladium (in the form of 0.5 mol % Pd2(dba)3) alongside 2 mol % 29g as ligand (Table , entry 2), and under these conditions, a conversion of 84% to 32 was achieved.

To further probe the utility of class="Chemical">1-aryl 5-phosphino 1,2,3-triazoles as ligands in Suzuki–Miyaura catalysis the synthesis of comclass="Chemical">pound 27 from class="Chemical">pan class="Chemical">aryl chloride 37 and boronic acid 26 was investigated (shown in Table ) deploying the same ligand set as in Table . The reaction conditions mirrored those used earlier for cross-coupling with bromide analogue 25 in Table , but in order to ensure good reaction conversions the reaction temperature was increased slightly (toluene at reflux).

Reaction conditions: class="Chemical">2-chloro-m-xylene (1.0 mmol), class="Chemical">pan class="Chemical">o-tolyboronic acid (1.5 mmol), potassium phosphate (3.0 mmol), Pd2(dba)3 (0.5 mol %), ligand (2.0 mol %), toluene (3 mL), 10 h, 90 °C.

Determined by GC analysis with pan class="Chemical">n-dodecane as internal standard.

pan class="Chemical">Pd2(dba)3 (0.25 mol %), ligand (1.0 mol %).

Under the reaction conditions employed (Table ), catalysts derived from class="Chemical">triazole-containing ligands 29g, class="Chemical">pan class="Chemical">29h, and 29m delivered compound 27 in quantitative yield (Table , entries 1, 3, and 4, respectively). Using 29g as ligand at a lower catalyst loading of 0.5 mol % of palladium proportionally, quantitative conversion to 27 (isolated yield 92%) was achieved. In this comparison, the use of S-Phos (7) as ligand gave 33% conversion (Table , entry 6), and the use of X-Phos (8) as ligand gave quantitative conversion (Table , entry 7) to compound 27.

Next, a demanding class="Chemical">palladium-catalyzed reaction between class="Chemical">pan class="Chemical">2-chloro-meta-xylene (37) and 2,4,6-trimethylphenylboronic acid (38) leading to product 32 was attempted. Two triazole ligand-based catalyst systems were compared against catalyst systems derived from S-Phos (7) and X-Phos (8); see Table .

Table 5

Ligand Screening: 1-Substituted 1,2,3-Triazole-Containing Phosphine Ligand Mediate, Palladium-Catalyzed, Reaction of Arylchloride 37 in Formation of 32

entry	ligand	conversion [%]a,b
1	29g	49
2	29m	37
3	S-Phos (7)	55
4	X-Phos (8)	5

Reaction conditions: 2-chloro-m-xylene (0.5 mmol), 2,4,6-trimethylphenylboronic acid (1.0 mmol), potassium phosphate (2 mmol), Pd2(dba)3 (2.0 mol %), ligand (8.0 mol %), toluene (3 mL), 18 h, reflux.

Determined by GC analysis with n-dodecane as internal standard.

Reaction conditions: class="Chemical">2-chloro-m-xylene (0.5 mmol), 2,4,6-trimethylclass="Chemical">phenylboronic acid (1.0 mmol), class="Chemical">pan class="Chemical">potassium phosphate (2 mmol), Pd2(dba)3 (2.0 mol %), ligand (8.0 mol %), toluene (3 mL), 18 h, reflux.

Determined by GC analysis with pan class="Chemical">n-dodecane as internal standard.

Under the conditions employed, the four catalyst systems compared produced only moderate yields. That is not to say that these reactions could not be optimized further, but the side-by-side comparison revealed class="Chemical">S-Phos (7) to be slightly better than class="Chemical">pan class="Chemical">triazole-containing phosphine 29g (55 versus 49% conversion; Table , entry 4 versus entry 1, respectively). Slightly lower conversions were obtained when 29m or X-Phos were used as ligands (Table entries 2 and 4 respectively).

One potential problem with Suzuki–Miyaura catalyzed reactions, particlass="Chemical">cularly evident when using less reactive class="Chemical">pan class="Chemical">aryl chlorides in cross-coupling, is homocoupling of the boronic acid containing reaction partner.[122] In order to test our routine reaction protocols and our four selected triazole ligands (29g, 29h, 29m, and 29n) for their propensity to lead to undesired homocoupled product, the following reaction was probed. Aryl chloride 33 was reacted with 1.5 equiv of phenyl boronic acid 34. Catalyst loading was 2 mol % palladium and 4 mol % ligand. The reactions were conducted in toluene at 90 °C with 3 equiv of potassium phosphate as base; see Scheme . Set up like this, we can judge a reaction to be successful, i.e., not suffering from an adventitious homocoupling side reaction leading to product composition, if conversion of aryl chloride 33 is high (near 100%) and the amount of formed byproduct 36 is low. Choosing 1.5 equiv of boronic acid gives a chance for the formation of 36, thus evidencing the cross- versus homo-coupling potential of the ligands in the chosen Suzuki–Miyaura reaction under the conditions described.

Scheme 8

Percentage Homo-Coupled Product 36 under Described Reaction Conditions Using 50% Excess Boronic Acid 34

All four of the tested ligands (Scheme , 29g, class="Chemical">29h, 29m, and 29n) gave good conversion to class="Chemical">product 35 (ligands class="Chemical">pan class="Chemical">29h and 29n leading to complete consumption of stating aryl chloride 33). In this case the apparently most bulky ligand, 29n, performed best giving just 6% (mol/mol) homocoupled product (36); the other three ligands gave rise to only slightly elevated amounts of homocoupled side product (10–12% (mol/mol)). Thus, demonstrating that under the conditions employed, reaction protocols used throughout this study do not suffer appreciably from loss of halide-containing starting materials through unwanted homocoupling.

Lead-like Compounds

While the results disclass="Chemical">cussed thus far have exemclass="Chemical">plified the effectiveness of ligands 29g and 29m to catalyze sterically demanding cross-couclass="Chemical">pling reactions, the ability to catalyze the cross-couclass="Chemical">pling of functionalities relevant to medicinal chemistry, to give lead- and drug-like class="Chemical">products remains a critical need in the agrochemical and class="Chemical">pharmaceutical sectors.[77] To this end, a range of bis-aromatic class="Chemical">products, containing motifs of the tyclass="Chemical">pe that are commonly encountered in medicinal chemistry,[123−125] were identified, and their synthesis embarked uclass="Chemical">pon. The class="Chemical">products of virtual Suzuki–Miyaura cross-couclass="Chemical">plings of 48 class="Chemical">pan class="Chemical">aromatic halides (iodides, bromides, or chlorides) and 44 aromatic boronic acids (or esters) from (i) a collection held within the lead research group; (ii) those curated within the University of Birmingham Scaffold Diversification Resource;[126] and (iii) drawn from a boronic acid collection via the GSK Free Building Blocks resource; were enumerated and analyzed by the online resource LLAMA (Figure ).[118]

Figure 9

Virtual Suzuki–Miyaura catalysis products generated and analyzed in the LLAMA web tool. Left: A log P versus molecular mass, Lipinski and lead-like space indicated. Right: PMI plot, rod, disc, sphere axis. (See the Supporting Information for data tables.)

Virtual Suzuki–Miyaura catalysis products generated and analyzed in the class="Species">LLAMA web tool. Left: A log P versus moleclass="Chemical">pan class="Chemical">cular mass, Lipinski and lead-like space indicated. Right: PMI plot, rod, disc, sphere axis. (See the Supporting Information for data tables.)

The open-access web tool class="Species">LLAMA allows the user to conduct virtual reactions and analyze the virtual class="Chemical">product library for moleclass="Chemical">pan class="Chemical">cular properties such as molecular weight, A log P, and 3D character. Figure left shows the full virtual library of 1661 compounds created from the virtual Suzuki–Miyaura cross-coupling of the boronic acids and aryl halides described above. It shows that while the majority of these virtual products fall within Lipinkski space (Mw < 500, A log P < 5) only ∼20% lie within lead-like space as defined by Churcher et al. (200 < Mw < 350, A log P < 3). This fact is illustrated by the lead-likeness penalty scores of these compounds, which have an average of 3.47. This penalty scoring system was developed by the creators of LLAMA to visualize how far away from ideal lead-likeness a compound may be and incorporates all determined molecular properties into one score. Figure (right side) shows the PMI analysis of the same 1661 virtual compounds in the library of virtual Suzuki–Miyaura cross-coupled products. A PMI plot describes the 3D shape of the lowest energy conformation of a compound on a triangular plot. The upper left corner represents rod-like compounds, the bottom corner represents disc-like compounds, and the upper right corner represents spherical compounds. This analysis shows that the majority of the virtual library resides close to the rod–disc axis, representing flat compounds.

From the 1661 virtual compounds constructed within the pan class="Species">LLAMA tool, 14 class="Chemical">possible class="Chemical">products that accessed class="Chemical">preferable lead-like chemical sclass="Chemical">pace and were selected for testing 29g-mediated Suzuki–Miyaura cross-couclass="Chemical">pling reactions, as in Scheme . In this case, the screening conditions involved microwave heating in a sealed-tube at 100 °C in class="Chemical">pan class="Chemical">acetonitrile for just 1 h. The possible products include challenging heteroatom-containing and/or ortho substituents, representing both a set of possible products displaying favorable characteristics for drug discovery and a robust challenge for road-testing our best new ligand, 29g.

Scheme 9

Microwave-Heated Synthesis (1 h) of 10 Lead-like Compounds by Suzuki–Miyaura Cross-Coupling Reactions Using 2 mol % Palladium and 4 mol % Ligand 29g

Pleasingly, most of the reactions attempted gave greater than 50% isolated yield of these challenging cross-coupled products (41a–j); however, pan class="Chemical">2-bromo-1-methyl-1H-imidazole 39g and (3,5-dimethylisoxazol-4-yl)boronic acid 40g failed to deliver detectable amounts of desired cross-couclass="Chemical">pled class="Chemical">products in four test scenarios under the conditions emclass="Chemical">ployed.

To determine the utility of the products created in this analysis, they were analyzed using the pan class="Species">LLAMA web tool to determine their suitability as lead-like comclass="Chemical">pounds (Figure ). Figure (left), shows how class="Chemical">products 41a–j exclass="Chemical">plore the drug-like sclass="Chemical">pace, with all class="Chemical">products lying within the Liclass="Chemical">pinski sclass="Chemical">pace (Mw < 500, A log P < 5) and a significant class="Chemical">proclass="Chemical">portion lying within the lead-like sclass="Chemical">pace (40% of the synthesized comclass="Chemical">pounds). This illustrates the class="Chemical">potential for this catalyst system to access both drug- and lead-like chemical sclass="Chemical">pace. Figure (right) shows a PMI analysis of class="Chemical">products 41a to j, this analysis demonstrates a caclass="Chemical">pability of this catalyst system to access nonflat Suzuki–Miyaura cross-couclass="Chemical">pled class="Chemical">products.

Figure 10

Left: Mw vs A log P. Right: PMI analysis of products synthesized in Scheme .

These analyzes show that these compounds can be described as high-quality starting points for drug discovery programs. These 10 compounds are now under evaluation for biological activity across a range of targets.[127]

Palladium Complexes

During the course of this study numerous attempts to grow crystals of class="Chemical">palladium-phosphine comclass="Chemical">plexes suitable for single crystal X-ray diffraction were made. Thus far, two attemclass="Chemical">pts to generate X-ray quality crystals of class="Chemical">pan class="Chemical">palladium phosphine complexes have been achieved, using ligands 29e and 29h with palladium(II) chloride.

The combination of 29e and class="Chemical">trans-Pd(CH3CN)2Cl2 in class="Chemical">pan class="Chemical">dichloromethane at room temperature led to the formation of material that was precipitated by addition of pentane and the residue thus obtained was recrystallized from dichloromethane and hexane. A representation of the single crystal XRD structure of the palladium complex (42) thus obtained is depicted in Figure . A 2:1 ligand/metal square planar trans dichloride palladium(II) complex 42 was identified. Complex 42 may offer insight into the structural features of 29 series complexes as catalysts. The five-membered 1,5-disubstituted 1,2,3-triazole core presents the triazole 2,6-bismethoxy aryl fragment oriented toward the metal with an aryl-centroid···Pd distance of 3.843(2) Å, in this solid-state structure. The triazole phosphine ligand offers a distinct geometric difference to phenylene core ligands (c.f., S-Phos and X-Phos, Figure ), being more akin to other five-membered ring core ligands (c.f., 9 and 10, Figure ), generating a slightly wider metal-binding pocket while still offering a stabilizing shield about the metal center.

Figure 11

Representation of the crystal structure of 42, ellipsoids are drawn at the 50% probability level (Ortep3 for Windows and PovRay). The structure contains a palladium complex, which is located on an inversion center and two molecules of dichloromethane per complex. Only half of the complex and one dichloromethane molecule are unique. Pd···P bond lengths 2.322(9) Å. 2,6-Bismethoxy aryl-centroid···Pd 3.843(2) Å. Symmetry code used to generate equivalent atoms: 1 – x, −y, −z.

Representation of the crystal structure of 42, ellipsoids are drawn at the 50% probability level (Ortep3 for Windows and PovRay). The structure contains a class="Chemical">palladium complex, which is located on an inversion center and two moleclass="Chemical">pan class="Chemical">cules of dichloromethane per complex. Only half of the complex and one dichloromethane molecule are unique. Pd···P bond lengths 2.322(9) Å. 2,6-Bismethoxy aryl-centroid···Pd 3.843(2) Å. Symmetry code used to generate equivalent atoms: 1 – x, −y, −z.

The combination of class="Chemical">29h and class="Chemical">pan class="Chemical">trans-Pd(CH3CN)2Cl2 in dichloromethane at room temperature led to the formation of material that was precepted by addition of pentane and recrystallized from dichloromethane and hexane. A representation of the single crystal XRD structure of the palladium complex (43) thus obtained is depicted in Figure . To our surprise, the XRD crystal structure shows 29h functioning as a 3-N-coordinating ligand, with two such ligations are present about a trans-dichloride palladium(II) metal center. Since ligand 29h functions as expected in the aforementioned catalyzed reactions, it is suggested that a more crystalline and readily formed (kinetic) complex is formed under the crystallization conditions employed. However, that this stable complex is formed reminds us of another potentially important feature of the triazole-core ligands, namely, a rear-side ancillary coordination point. It is conceivable that the ancillary nitrogen may offer some advantages in some catalyzed reaction, such as aggregation suppression for example. Suffice it to say, the sterically encumbered phosphine face of ligand 29h, as evidenced by the isolation of 43, bodes well for understanding differing catalysis modes of action on steric rationales as well as opportunities for divergence from phenylene core ligands.

Figure 12

Representation of the crystal structure of 43, ellipsoids are drawn at the 50% probability level (Ortep3 for Windows and PovRay). The structure contains two molecules of dichloromethane per palladium complex (omitted for clarity).

Representation of the crystal structure of 43, ellipsoids are drawn at the 50% probability level (Ortep3 for Windows and PovRay). The structure contains two moleclass="Chemical">cules of class="Chemical">pan class="Chemical">dichloromethane per palladium complex (omitted for clarity).

Describing Phosphines

There is a growing body of literature disclass="Chemical">cussing the imclass="Chemical">portance of various class="Chemical">parameters including steric effects[116] of bulky class="Chemical">pan class="Chemical">phosphines[83,84,128] relating to suitability and efficacy in catalysis (primarily as ligands for metals in metal mediated catalysis).[108,115,129] While the Tolman cone angle has been an effective descriptor of ligand bulkiness for many years,[111] it has been complimented more recently by Nolan’s percentage buried volume parameter (%Vbur).[112] The %Vbur of ligands can be calculated using the SambVca (2.0) free web tool from Cavallo and co-workers;[113,130] so we set about determining some steric parameters of our phosphines using this tool.

First, the crystal structure of the free ligand 29g was investigated, as follows: The class="Chemical">PDB file corresclass="Chemical">ponding to the XRD crystal structure of ligand 29g was edited in Sclass="Chemical">partan’16 Parallel Suite (Wave function Inc.) by changing the valence of class="Chemical">pan class="Chemical">phosphorus to four and adding a palladium atom with a standard bond length of 2.280 Å to generate a metal-coordinated model. The PBD file thus generated was not minimized or edited further, i.e., the atoms of the ligand remained in their crystallographically determined free-ligand position, and uploaded for analysis to the SambVca2.0 web tool for analysis. The added palladium atom was set as the center and then deleted; a summary of this analysis is shown in Figure . A steric map generated from this analysis is shown and a 47.0%Vbur was calculated, using otherwise default SambVca settings.

Figure 13

Steric map of phosphine-palladium complex: Derived from crystal structure of free ligand 29g with a P–Pd distance of 2.280 Å applied, resulting in a 47.0%Vbur.

Steric map of class="Chemical">phosphine-class="Chemical">pan class="Chemical">palladium complex: Derived from crystal structure of free ligand 29g with a P–Pd distance of 2.280 Å applied, resulting in a 47.0%Vbur.

Following this analysis, the only class="Chemical">palladium phosphine comclass="Chemical">plex thus far successfully analyzed by single crystal X-ray diffraction studies (42) was investigated in a similar manner. Comclass="Chemical">pound 42 is a square class="Chemical">planar class="Chemical">pan class="Chemical">palladium(II) complex of ligand 29e and as such does not necessarily represent the catalytically relevant species, the determined %Vbur of 36.2% (Figure i) may not be the best comparator across a number of ligand structures, so three other forms of the complex were generated and compared. In order to find an appropriate comparison to fairly evaluate relative steric parameters of ligands 29e and 29g. The ligand portion of the crystal structure of 42 was edited in Spartan’16 Parallel Suite, the Pd–P bond length adjusted to 2.280 Å, and the SambVca-determined %Vbur of 36.9% (Figure ii) was essentially the same as that for the slightly longer, crystallographically determined, Pd–P bond length in the earlier analysis. Since a model to allow for comparison of ligands where crystallographically determined data is not available was ultimately sought two further analyses were conducted.

Figure 14

(i) Chemical structure of part of the crystallographically determined complex 42, with a 2.323(2) Å Pd–P distance (from the crystal structure) used in the calculation of buried volume, 36.2%Vbur. (ii) Chemical structure of the bond-length-modified, crystal-structure-informed palladium complex of ligand 29e in complex 42 (2.280 Å Pd–P distance was used in the buried volume calculation), 36.9%Vbur.

(i) Chemical structure of part of the crystallographically determined complex 42, with a 2.323(2) Å class="Chemical">Pd–P distance (from the crystal structure) used in the calclass="Chemical">pan class="Chemical">culation of buried volume, 36.2%Vbur. (ii) Chemical structure of the bond-length-modified, crystal-structure-informed palladium complex of ligand 29e in complex 42 (2.280 Å Pd–P distance was used in the buried volume calculation), 36.9%Vbur.

Sigman and co-workers have previously used class="Chemical">phosphine oxides as comclass="Chemical">putational models for structural minimization class="Chemical">proxies of ligand–class="Chemical">pan class="Chemical">metal complexes,[115] so it was reasoned that computational minimization of in silico generated phosphine oxides may be a sensible starting point to allow for comparison among some of the ligands in this report. Two approaches were compared for optimizing and computationally determining the %Vbur of ligand 29e (summarized in Figure ) using Spartan’16 Parallel Suite. In one case a phosphine oxide structure with no geometric restrictions was used (Figure , right); in the second case, the dihedral geometries of atoms 1–6 were restricted presenting the ligand’s ancillary aryl group directly and orthogonally aligned to the coordination vector of the phosphine (the P–O bond in this minimization), as shown in (Figure , left). Through comparison of the geometry unrestricted and geometry restricted protocols, with the structurally determined geometry (as shown in Figure ) a protocol for analysis across the ligands of this report might be reasonably determined. In both cases the same minimization and optimization cascade was adopted; the structures used for computationally determined %Vbur calculations were obtained as follows. First, molecular mechanics (MMFF) conformer distribution (1000 max conformers) and subsequent molecular mechanics equilibrium geometries were ranked, and the 20 lowest energy conformers were retained for DFT investigation. The 20 retained conformers’ equilibrium geometries were used as starting points for ground-state, gas phase equilibrium geometry determination (B3LYP 6-31G*). The lowest energy structure thus obtained was then edited to replace the oxygen (of the phosphine oxide) with a palladium atom and a standard P–Pd bond length of 2.280 Å was applied (Figure , center).

Figure 15

Protocol for obtaining structures for comparison of steric parameters via an unrestricted (right) and a dihedral angles restricted model (left). In both cases, a phosphine oxide model was minimized using Spartan’16 and the P=O later replaced with a P–Pd bond of 2.280 Å. The structures thus obtained were then analyzed by the SambVca2.0 free web tool to determine the %Vbur and to create a steric map.

Protocol for obtaining structures for comparison of steric parameters via an unrestricted (right) and a dihedral angles restricted model (left). In both cases, a pan class="Chemical">phosphine oxide model was minimized using Sclass="Chemical">partan’16 and the P=O later reclass="Chemical">placed with a P–class="Chemical">pan class="Chemical">Pd bond of 2.280 Å. The structures thus obtained were then analyzed by the SambVca2.0 free web tool to determine the %Vbur and to create a steric map.

The procedure outlined in Figure was first applied to ligand 29e, and buried volumes of 44.2 and 47.3% were determined for the restricted and unrestricted geometries, respectively (Figure ) and compared to the buried volume determined crystallographically. While this protocol gives slightly higher values, the restricted geometry model is more closely aligned to the XRD-derived model than the unrestricted one. With this information alone, it is diffipan class="Chemical">cult to ascertain if any one model class="Chemical">provides a suclass="Chemical">perior aclass="Chemical">pclass="Chemical">proach for assessing ligands where solid state data is not available. Furthermore, it should be remembered that the 42-derived %Vbur numbers are from solid-state structures and might not offer the best cross-ligand comclass="Chemical">parison. As such, the most active ligands of our study were examined using both class="Chemical">protocols shown below (Figure ).

Figure 16

(i) Chemical structure and computationally determined steric map and buried volume, structures derived in silico and calculated with restricted dihedral angles as describe in Figure (left), 44.2%Vbur. (ii) Chemical structure and computationally determined steric map and buried volume of structures derived in silico and calculated without any dihedral restrictions as describe in Figure (right), 47.3%Vbur.

Figure 17

SambVca2.0 derived %Vbur and steric maps for the: (a) left side: (i) 29g; (ii) 29h; (iii) 29n; (iv) 29m; (v) 7 S-Phos; (vi) 8 X-Phos, derived palladium complexes of structures derived in silico and calculated with restricted dihedral angles as describe in Figure (left); (b) right side: (i) 29g; (ii) 29h; (iii) 29n; (iv) 29m; (v) 7 S-Phos; (vi) 8 X-Phos, derived palladium complexes of structures derived in silico and calculated without any dihedral restrictions as describe in Figure (right).

(i) Chemical structure and computationally determined steric map and buried volume, structures derived in silico and calpan class="Chemical">culated with restricted dihedral angles as describe in Figure (left), 44.2%Vbur. (ii) Chemical structure and comclass="Chemical">putationally determined steric maclass="Chemical">p and buried volume of structures derived in silico and calclass="Chemical">pan class="Chemical">culated without any dihedral restrictions as describe in Figure (right), 47.3%Vbur.

SambVca2.0 derived %Vbur and steric maps for the: (a) left side: (i) 29g; (ii) class="Chemical">29h; (iii) 29n; (iv) 29m; (v) 7 class="Chemical">pan class="Chemical">S-Phos; (vi) 8 X-Phos, derived palladium complexes of structures derived in silico and calculated with restricted dihedral angles as describe in Figure (left); (b) right side: (i) 29g; (ii) 29h; (iii) 29n; (iv) 29m; (v) 7 S-Phos; (vi) 8 X-Phos, derived palladium complexes of structures derived in silico and calculated without any dihedral restrictions as describe in Figure (right).

Computed structures, percentage buried volumes, and steric maps of the six ligands of Figure , following the protocol outlined in Figure , are shown in Figure . The left side shows the information relating to restricted dihedral angle restricted complexes and the right side shows the structures obtained without imposing any geometrical restrictions (other than the 2.280 Å P–class="Chemical">Pd distances imclass="Chemical">posed throughout). It is interesting and confounded our exclass="Chemical">pectations that the unrestricted geometry-minimized structures give a higher buried volume than the restricted dihedral angle structures (Figure column a versus column b). Among the two data treatments, there is broad agreement with and relative similarity to each other. While the geometry-unrestricted structures of class="Chemical">pan class="Chemical">triazole ligands bear a striking resemblance (by rudimentary visual inspection) to any XRD-derived structures, the buried volume determinations of previously reported S- and X-Phos (by the P=O minimization proxy discussed earlier) complexes more closely match the geometry-restricted models we employed (Table , entries 6 and 7).

Table 6

Calculated (Spartan v16 and SambVca2.0) Steric Properties of 29e, 29g, 29h, 29m, 29n, S-Phos 7, and X-Phos 8

entry	ligand	Vbur calcd [%] (restricted)	Vbur calcd [%] (unrestricted)	Ar centroid–Pd distance [Å] (restricted)	Ar centroid–Pd distance [Å] (unrestricted)
1	29e	44.2 (36.2)a	47.3	3.363 (3.843(2))a	4.176
2	29g	45.5 (46.9)b	49.6	3.403 (3.457)b	3.745
3	29h	47.8	50.1	3.558	3.580
4	29m	47.1	48.0	3.639	3.901
5	29n	47.5	53.3	3.647	3.794
6	7 (S-Phos)	50.8 (49.7)c	55.4	3.127	3.253
7	8 (X-Phos)	53.3 (53.1)c	53.2	3.309	3.481

Measured from the unadjusted XRD structure of 42.

Using free ligand 29g XRD and applying Pd–P bond length 2.280 Å.

Refers to ligand/metal 1:1 complex P-M distance 2.8 A (M = Au).[112,131]

Using free ligand 29g XRD and applying pan class="Chemical">Pd–P bond length 2.280 Å.

Refers to ligand/pan class="Chemical">metal 1:1 comclass="Chemical">plex P-M distance 2.8 A (M = Au).[112,131]

From the steric maps of Figure , it was noted that the space between the dark red bulky zone (to the left of the steric maps arising from the ancillary aryl groups of all ligands) protrudes in a manner to give more space between the central axis and red zone. Since space near the coordination site may be crucial in permitting reaction with bulky substrates, we also report the distance between the ancillary aryl group’s centroid and the computed pan class="Chemical">metal center (Table ) for both the geometry-restricted and unrestricted ligands of Figure are also listed in Table (and contrasted against the data determined for ligand 29e). In Entry 2 the data arising from analysis of the class="Chemical">previously detailed ligand crystal-structure-determined structures of 29g–comclass="Chemical">plexes are given in class="Chemical">parentheses. Between the restricted and unrestricted models of ligand–comclass="Chemical">plex analysis, the centroid distance correlates more closely with the dihedral angle restricted model of a 29g–class="Chemical">pan class="Chemical">Pd complex.

It is notable that the P=O ligand minimization protocol adopted gives good structural parameter agreement between those determined for pan class="Chemical">palladium complexes of ligand 29g both derived comclass="Chemical">putationally and from a modified XRD structure of free ligand 29g (Table , entry 1). By analyzing 29a–n side-by-side using the same restricted dihedral angle minimization class="Chemical">protocol (uclass="Chemical">p to 10 conformers analyzed by DFT methods abbreviating the earlier minimization cascade for newly analyzed ligands) and class="Chemical">plotting the comclass="Chemical">puted %Vbur values against conversion to 27 (data from Table ), as shown in Figure , it can be seen that a strong bulkiness versus conversion trend exists. Essentially any %Vbur value above 46% leads to quantitative conversion to class="Chemical">products, under the class="Chemical">prescribed conditions.

Figure 18

Conversion to 27 (see Table ) versus computed burried volume (%) as determined by the protocol discussed in Figure .

Conversion to 27 (see Table ) versus computed burried volume (%) as determined by the protocol dispan class="Chemical">cussed in Figure .

Further analysis of the data obtained for conversion in reactions catalyzed by 29 ligands is only against smaller data sets, and significant correlations of variances in conversions do not lead to any meaningfully comparable correlations. However, further study of cross-couplings of very bulky pan class="Chemical">aryl chlorides may be warranted in the future since an intriguing balance between bulk and centroid distance is suggested (see the Suclass="Chemical">pclass="Chemical">porting Information), but across only four data class="Chemical">points surveyed to date, it may be too early to draw conclusion yet.[132] A class="Chemical">pre-class="Chemical">peer-reviewed class="Chemical">preclass="Chemical">print of this article was declass="Chemical">posited and may be viewed elsewhere.[133]

Conclusions

Two series of class="Chemical">1,2,3-triazole-containing class="Chemical">pan class="Chemical">5-phosphino ligands were synthesized and tested as ligands in palladium catalyzed cross-coupling Suzuki–Miyaura reactions of bulky and heteroatom-containing substrates. The structural parameters of the 4-H triazole series (29) were determined by a restricted dihedral angle, phosphine oxide surrogate model, and a strong dependence upon bulkiness and catalytic activity were noted. Furthermore, a link to the space between the metal and the ancillary aryl group in the computed complexes was noted, suggesting bulkiness of ligand and space around the metal may both be implicated in delineating trends in cross-coupling of the most bulky and challenging substrates. Notably, triazole-nitrogens’ may not be completely innocent in the coordination environment created by these ligands, with a nitrogen coordination complex being characterized by XRD in one case. The ligands synthesized were benchmarked against commercially available ligands (X- and S-Phos) and in some cases the best triazole ligands match or outperformed them under the employed conditions, in like-for-like tests in triplicate. The phosphine ligands reported and characterized in this report represent easy to modify catalytic scaffolds that could be use in future library generation efforts and we are looking forward to facilitating access to these compounds and allowing others to include this type of ligand in their own catalyst screening campaigns.