| Literature DB >> 30523859 |
E N Bolbasov1, D A Popkov, N A Kononovich, E N Gorbach, I A Khlusov, A S Golovkin, K S Stankevich, V P Ignatov, V M Bouznik, Y G Anissimov, S I Tverdokhlebov, A V Popkov.
Abstract
This study aims to investigate the comparative study of calcium phosphate coatings for flexible intramedullary nails (FINs) used to lengthen long tubular bones. The presence of a calcium phosphate coating deposited by micro-arc oxidation (MAO) or a composite coating based on a co-polymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) on the surface of the FIN significantly enhanced the regeneration of bone in the area of osteotomy during limb lengthening by combined osteosynthesis. The investigation of the physico-chemical properties of the FIN coated with calcium phosphate via MAO demonstrated that the improved bone tissue formation resulted from favourable conditions for adhesion, proliferation and differentiation of multipotent stem cells into osteoblasts on the coating surface. The composite coatings only stimulated the formation of bone tissue in vivo, primarily because of the piezoelectric properties of the VDF-TeFE co-polymer.Entities:
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Year: 2019 PMID： 30523859 DOI： 10.1088/1748-605X/aaf60c
Source DB: PubMed Journal: Biomed Mater ISSN： 1748-6041 Impact factor: 3.715