Damien Legallois1,2, Pierre-Yves Marie3, Philippe R Franken4, Wassila Djaballah3, Denis Agostini1,5, Alain Manrique6,7,8. 1. Normandie Université, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. 2. Department of Cardiology, CHU de Caen, 14000, Caen, France. 3. Department of Nuclear Medicine, CHU de Nancy, 54000, Nancy, France. 4. AZ-VUB Nuclear Medicine Jette, Brussels, Belgium. 5. Department of Nuclear Medicine, CHU de Caen, 14000, Caen, France. 6. Normandie Université, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. manrique@cyceron.fr. 7. Department of Nuclear Medicine, CHU de Caen, 14000, Caen, France. manrique@cyceron.fr. 8. Investigations chez l'Homme, GIP Cyceron PET Center, Campus Jules Horowitz, BP 5229, 14074, Caen, France. manrique@cyceron.fr.
Abstract
BACKGROUND: This study aimed to determine whether the repeatability of dyssynchrony assessment using gated myocardial perfusion SPECT (GSPECT) allows the detection of synchrony reserve during low-dose dobutamine infusion. METHODS AND RESULTS: Sixty-one patients with ischemic cardiomyopathy and LV ejection fraction < 50% were prospectively included in 10 centers. Each patient underwent two consecutive rest GSPECT with 99mTc-labeled tracer (either tetrofosmin or sestamibi) to assess the repeatability of LV function and dyssynchrony parameters, followed by a GSECT acquisition during low-dose dobutamine infusion. LV dyssynchrony was assessed using QGS software through histogram bandwidth (BW), standard deviation of the phase (SD), and entropy. Repeatability was assessed with Lin's concordance correlation coefficient (CCC). Entropy showed a higher CCC (0.80) compared to BW (0.68) and SD (0.75). On average, dobutamine infusion yielded to improve both BW (P = .049) and entropy (P = .04) although significant improvements, setting outside the 95% confidence interval of the repeatability analysis, were documented in only 6 and 4 patients for BW and entropy, respectively. CONCLUSIONS: A synchrony reserve may be documented in patients with ischemic cardiomyopathy through the recording of BW and entropy with low-dose dobutamine GSPECT, with the additional advantage of a higher repeatability for entropy.
BACKGROUND: This study aimed to determine whether the repeatability of dyssynchrony assessment using gated myocardial perfusion SPECT (GSPECT) allows the detection of synchrony reserve during low-dose dobutamine infusion. METHODS AND RESULTS: Sixty-one patients with ischemic cardiomyopathy and LV ejection fraction < 50% were prospectively included in 10 centers. Each patient underwent two consecutive rest GSPECT with 99mTc-labeled tracer (either tetrofosmin or sestamibi) to assess the repeatability of LV function and dyssynchrony parameters, followed by a GSECT acquisition during low-dose dobutamine infusion. LV dyssynchrony was assessed using QGS software through histogram bandwidth (BW), standard deviation of the phase (SD), and entropy. Repeatability was assessed with Lin's concordance correlation coefficient (CCC). Entropy showed a higher CCC (0.80) compared to BW (0.68) and SD (0.75). On average, dobutamine infusion yielded to improve both BW (P = .049) and entropy (P = .04) although significant improvements, setting outside the 95% confidence interval of the repeatability analysis, were documented in only 6 and 4 patients for BW and entropy, respectively. CONCLUSIONS: A synchrony reserve may be documented in patients with ischemic cardiomyopathy through the recording of BW and entropy with low-dose dobutamine GSPECT, with the additional advantage of a higher repeatability for entropy.
Authors: K Yoshinaga; K Morita; S Yamada; K Komuro; C Katoh; Y Ito; Y Kuge; T Kohya; A Kitabatake; N Tamaki Journal: J Nucl Med Date: 2001-06 Impact factor: 10.057
Authors: Pierre-Yves Marie; Wassila Djaballah; Philippe R Franken; Chris Vanhove; Marc A Muller; Henri Boutley; Sylvain Poussier; Pierre Olivier; Gilles Karcher; Alain Bertrand Journal: J Nucl Med Date: 2005-11 Impact factor: 10.057
Authors: Vladimir V Shipulin; Sergey L Andreev; Andrew S Pryakhin; Andrew V Mochula; Alina N Maltseva; Svetlana I Sazonova; Vladimir M Shipulin; Samia Massalha; Konstantin V Zavadovsky Journal: Eur J Nucl Med Mol Imaging Date: 2022-02-12 Impact factor: 10.057