A P Poornima1, Shiffi Fazal2, P S Shaiji2, K C Usha2, Lalitha Kailas3. 1. Department of Transfusion Medicine, Government Medical College, Thiruvananthapuram, Kerala, 695011, India. drpoornimaap@gmail.com. 2. Department of Transfusion Medicine, Government Medical College, Thiruvananthapuram, Kerala, 695011, India. 3. Department of Pediatrics, Government Medical College, Thiruvananthapuram, Kerala, India.
Abstract
OBJECTIVES: To estimate the prevalence and specificity pattern of red blood cell (RBC) alloimmunization among pediatric multitransfused patients, and to identify the factors associated with alloimmunization. METHODS: This was a descriptive cross-sectional study conducted among mutitransfused pediatric patients over a period of two years. The relevant clinical details of patients were collected, and RBC antibody screening was done. Samples with positive antibody screen were subjected to antibody identification. Patient factors were analysed to find any significant relation to the development of RBC alloimmunization. RESULTS: Alloantibodies were obtained in 4 (6.35%) of the total 63 patients, and autoantibody in 1 (1.59%). The specificities of alloantibodies identified were all against Rh antigens-one each of anti E, anti c, anti Cw and anti D + anti C. A significant association was seen between development of alloimmunization and first transfusion at more than 2 y of age. CONCLUSIONS: RBC alloimmunization against Rhesus (Rh) antigens is a significant problem for multitransfused children in our population. Extended RBC phenotyping at least for antigens of the Rh system and provision of antigen matched RBCs may be an option for such children, where ongoing transfusion requirement is anticipated.
OBJECTIVES: To estimate the prevalence and specificity pattern of red blood cell (RBC) alloimmunization among pediatric multitransfused patients, and to identify the factors associated with alloimmunization. METHODS: This was a descriptive cross-sectional study conducted among mutitransfused pediatric patients over a period of two years. The relevant clinical details of patients were collected, and RBC antibody screening was done. Samples with positive antibody screen were subjected to antibody identification. Patient factors were analysed to find any significant relation to the development of RBC alloimmunization. RESULTS: Alloantibodies were obtained in 4 (6.35%) of the total 63 patients, and autoantibody in 1 (1.59%). The specificities of alloantibodies identified were all against Rh antigens-one each of anti E, anti c, anti Cw and anti D + anti C. A significant association was seen between development of alloimmunization and first transfusion at more than 2 y of age. CONCLUSIONS: RBC alloimmunization against Rhesus (Rh) antigens is a significant problem for multitransfused children in our population. Extended RBC phenotyping at least for antigens of the Rh system and provision of antigen matched RBCs may be an option for such children, where ongoing transfusion requirement is anticipated.
Authors: V S Sakhalkar; K Roberts; L M Hawthorne; D M McCaskill; D M Veillon; G C Caldito; J D Cotelingam Journal: Ann N Y Acad Sci Date: 2005 Impact factor: 5.691
Authors: Martijn P Bauer; Jo Wiersum-Osselton; Martin Schipperus; Jan P Vandenbroucke; Ernest Briët Journal: Transfusion Date: 2007-11 Impact factor: 3.157