Literature DB >> 30515494

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude.

A Gigante1, J-N Grad, J Briels, M Bartel, D Hoffmann, C Ottmann, C Schmuck.   

Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

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Year:  2018        PMID： 30515494     DOI： 10.1039/c8cc07946c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Evolution of Artificial Arginine Analogues-Fluorescent Guanidiniocarbonyl-Indoles as Efficient Oxo-Anion Binders.

Authors:  Daniel Sebena; Kevin Rudolph; Bibhisan Roy; Christoph Wölper; Till Nitschke; Sarah Lampe; Michael Giese; Jens Voskuhl
Journal:  Molecules       Date:  2022-05-07       Impact factor: 4.927

2.  Targeting the Surface of the Protein 14-3-3 by Ultrasmall (1.5 nm) Gold Nanoparticles Carrying the Specific Peptide CRaf.

Authors:  Tatjana Ruks; Kateryna Loza; Marc Heggen; Christian Ottmann; Peter Bayer; Christine Beuck; Matthias Epple
Journal:  Chembiochem       Date:  2021-01-28       Impact factor: 3.164

3.  Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups.

Authors:  Neda Rafieiolhosseini; Matthias Killa; Thorben Neumann; Niklas Tötsch; Jean-Noël Grad; Alexander Höing; Thies Dirksmeyer; Jochen Niemeyer; Christian Ottmann; Shirley K Knauer; Michael Giese; Jens Voskuhl; Daniel Hoffmann
Journal:  Beilstein J Org Chem       Date:  2022-09-23       Impact factor: 2.544

Review 4.  NMR Spectroscopy of supramolecular chemistry on protein surfaces.

Authors:  Peter Bayer; Anja Matena; Christine Beuck
Journal:  Beilstein J Org Chem       Date:  2020-10-09       Impact factor: 2.883
  4 in total

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