Daniela Perani1,2,3, Stefania Lalli4,5, Leonardo Iaccarino1,2, Pierpaolo Alongi3, Orsola Gambini6, Angelo Franzini7, Alberto Albanese4,5. 1. Vita-Salute San Raffaele University Milan Italy. 2. In vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience IRCCS San Raffaele Scientific Institute Milan Italy. 3. Nuclear Medicine Unit IRCCS San Raffaele Hospital Milan Italy. 4. Department of Neurology Catholic University of the Sacred Heart Milan Italy. 5. Department of Neurology Humanitas Research Hospital Rozzano Milan Italy. 6. Department of Psychiatry University of Milan Medical School and San Paolo Hospital Milan Italy. 7. Department of Neurosurgery Istituto Neurologico "C. Besta" Milan Italy.
Abstract
BACKGROUND: The benefits of neurosurgery in Tourette Syndrome (TS) are still incompletely understood. Prefrontal cortical electrical stimulation offers a less invasive alternative to deep brain stimulation. OBJECTIVE: To perform a pilot assessment on safety and efficacy of prefrontal cortical bilateral electrical stimulation in TS using clinical and brain metabolic assessments. METHODS: Four adult TS patients underwent tic assessment using the Yale Global Tic Severity Scale and the Rush Video Rating Scale at baseline and 1, 3, 6, and 12-months after implant; whereas FDG-PET scans were acquired at baseline and after 6 and 12 months. RESULTS: Tic clinical scores were improved at 6 months after implant, meanwhile they showed a tendency to re-emerge at the 12-month follow-up. There was a correlation between FDG-PET and tics, mainly consisting in a reduction of baseline brain hypermetabolism, which paralleled tic score reduction. CONCLUSION: Epidural stimulation in TS is safe and yields a modulation of tics, paralleled by FDG-PET metabolic modulation.
BACKGROUND: The benefits of neurosurgery in Tourette Syndrome (TS) are still incompletely understood. Prefrontal cortical electrical stimulation offers a less invasive alternative to deep brain stimulation. OBJECTIVE: To perform a pilot assessment on safety and efficacy of prefrontal cortical bilateral electrical stimulation in TS using clinical and brain metabolic assessments. METHODS: Four adult TS patients underwent tic assessment using the Yale Global Tic Severity Scale and the Rush Video Rating Scale at baseline and 1, 3, 6, and 12-months after implant; whereas FDG-PET scans were acquired at baseline and after 6 and 12 months. RESULTS: Tic clinical scores were improved at 6 months after implant, meanwhile they showed a tendency to re-emerge at the 12-month follow-up. There was a correlation between FDG-PET and tics, mainly consisting in a reduction of baseline brain hypermetabolism, which paralleled tic score reduction. CONCLUSION: Epidural stimulation in TS is safe and yields a modulation of tics, paralleled by FDG-PET metabolic modulation.
Authors: Eric A Storch; Alessandro S De Nadai; Adam B Lewin; Joseph F McGuire; Anna M Jones; P Jane Mutch; R Doug Shytle; Tanya K Murphy Journal: J Child Adolesc Psychopharmacol Date: 2011-11-09 Impact factor: 2.576
Authors: Pasquale Anthony Della Rosa; Chiara Cerami; Francesca Gallivanone; Annapaola Prestia; Anna Caroli; Isabella Castiglioni; Maria Carla Gilardi; Giovanni Frisoni; Karl Friston; John Ashburner; Daniela Perani Journal: Neuroinformatics Date: 2014-10
Authors: Kara A Johnson; Gordon Duffley; Daria Nesterovich Anderson; Jill L Ostrem; Marie-Laure Welter; Juan Carlos Baldermann; Jens Kuhn; Daniel Huys; Veerle Visser-Vandewalle; Thomas Foltynie; Ludvic Zrinzo; Marwan Hariz; Albert F G Leentjens; Alon Y Mogilner; Michael H Pourfar; Leonardo Almeida; Aysegul Gunduz; Kelly D Foote; Michael S Okun; Christopher R Butson Journal: Brain Date: 2020-08-01 Impact factor: 13.501