OBJECTIVE: To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders. METHOD: Youth with a tic disorder (N=108; range=5-17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I). RESULTS: A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders. CONCLUSIONS: A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e.g., change medications, etc.).
OBJECTIVE: To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders. METHOD: Youth with a tic disorder (N=108; range=5-17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I). RESULTS: A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders. CONCLUSIONS: A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e.g., change medications, etc.).
Authors: J Kaufman; B Birmaher; D Brent; U Rao; C Flynn; P Moreci; D Williamson; N Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-07 Impact factor: 8.829
Authors: L Scahill; P B Chappell; Y S Kim; R T Schultz; L Katsovich; E Shepherd; A F Arnsten; D J Cohen; J F Leckman Journal: Am J Psychiatry Date: 2001-07 Impact factor: 18.112
Authors: John Piacentini; Douglas W Woods; Lawrence Scahill; Sabine Wilhelm; Alan L Peterson; Susanna Chang; Golda S Ginsburg; Thilo Deckersbach; James Dziura; Sue Levi-Pearl; John T Walkup Journal: JAMA Date: 2010-05-19 Impact factor: 56.272
Authors: D V Sheehan; Y Lecrubier; K H Sheehan; P Amorim; J Janavs; E Weiller; T Hergueta; R Baker; G C Dunbar Journal: J Clin Psychiatry Date: 1998 Impact factor: 4.384
Authors: Tanya K Murphy; P Jane Mutch; Jeannette M Reid; Paula J Edge; Eric A Storch; Michael Bengtson; Mark Yang Journal: J Child Adolesc Psychopharmacol Date: 2009-08 Impact factor: 2.576
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Authors: Davide Martino; Tamara M Pringsheim; Andrea E Cavanna; Carlo Colosimo; Andreas Hartmann; James F Leckman; Sheng Luo; Alexander Munchau; Christopher G Goetz; Glenn T Stebbins; Pablo Martinez-Martin Journal: Mov Disord Date: 2017-01-10 Impact factor: 10.338
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