Literature DB >> 30513339

The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions.

Prasanthi Polamreddy1, Nandu Gattu2.   

Abstract

As the name suggests, drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued and/or shelved drugs, and drug candidates currently in clinical development. Although not a recent concept, drug repurposing has gained momentum over the past few years and several drugs have been successfully repurposed. Here, we summarize the drug repurposing landscape from 2012 to 2017, with a major focus on repurposed drugs, collaborative opportunities, and funding opportunities specific to drug repurposing projects. Along with success stories, we also highlight the challenges and limitations associated with drug repurposing.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Mesh：

Year:  2018        PMID： 30513339     DOI： 10.1016/j.drudis.2018.11.022

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  22 in total

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Journal:  ACS Pharmacol Transl Sci       Date:  2020-11-11

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4.  Drugs and biologics receiving FDA orphan drug designation: an analysis of the most frequently designated products and their repositioning strategies.

Authors:  Kathleen L Miller; Selma Kraft; Abraham Ipe; Lewis Fermaglich
Journal:  Expert Opin Orphan Drugs       Date:  2022-03-01       Impact factor: 1.041

Review 5.  Repurposing drug molecules for new pulmonary therapeutic interventions.

Authors:  Piyush P Mehta; Vividha S Dhapte-Pawar
Journal:  Drug Deliv Transl Res       Date:  2020-11-13       Impact factor: 4.617

Review 6.  Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target.

Authors:  Saiful Islam; Shudong Wang; Nikola Bowden; Jennifer Martin; Richard Head
Journal:  Br J Clin Pharmacol       Date:  2021-07-09       Impact factor: 3.716

Review 7.  Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs.

Authors:  Walter H Moos; Douglas V Faller; Ioannis P Glavas; David N Harpp; Iphigenia Kanara; Anastasios N Mavrakis; Julie Pernokas; Mark Pernokas; Carl A Pinkert; Whitney R Powers; Konstantina Sampani; Kosta Steliou; Demetrios G Vavvas; Robert J Zamboni; Krishna Kodukula; Xiaohong Chen
Journal:  Biores Open Access       Date:  2020-03-31

Review 8.  Revealing Drug-Target Interactions with Computational Models and Algorithms.

Authors:  Liqian Zhou; Zejun Li; Jialiang Yang; Geng Tian; Fuxing Liu; Hong Wen; Li Peng; Min Chen; Ju Xiang; Lihong Peng
Journal:  Molecules       Date:  2019-05-02       Impact factor: 4.411

Review 9.  A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery.

Authors:  Thanigaimalai Pillaiyar; Sangeetha Meenakshisundaram; Manoj Manickam; Murugesan Sankaranarayanan
Journal:  Eur J Med Chem       Date:  2020-04-02       Impact factor: 6.514

Review 10.  Drug repurposing for COVID-19: Approaches, challenges and promising candidates.

Authors:  Yan Ling Ng; Cyrill Kafi Salim; Justin Jang Hann Chu
Journal:  Pharmacol Ther       Date:  2021-06-23       Impact factor: 12.310
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