Literature DB >> 33188495

Repurposing drug molecules for new pulmonary therapeutic interventions.

Piyush P Mehta1, Vividha S Dhapte-Pawar2.   

Abstract

Drug repurposing with novel strategies has substantially contributed to the identification and analysis of new molecules for better pulmonary intervention. This review would offer insights into the drug repurposing for effective pulmonary therapy. The review begins by explaining the relevant background knowledge of drug repurposing, the need for drug repurposing, and their potential advantages in treating pulmonary diseases. This article takes into account clinical trial problems, drug delivery challenges, regulatory issues, and human ergonomics along with chemistry manufacturing and control strategies for effective pulmonary drug repurposing. This article elaborates on pulmonary drug repurposing with help of strengths, weaknesses, opportunities, and threat analysis. In brief, this article is the first inclusive account of drug repurposing for better pulmonary therapy. Graphical abstract.
© 2020. Controlled Release Society.

Entities:  

Keywords:  Drug repurposing; Inhaled formulations and clinical trials; Pulmonary delivery

Mesh:

Substances:

Year:  2020        PMID: 33188495     DOI: 10.1007/s13346-020-00874-6

Source DB:  PubMed          Journal:  Drug Deliv Transl Res        ISSN: 2190-393X            Impact factor:   4.617


  37 in total

Review 1.  Inhalation therapy: an historical review.

Authors:  Mark Sanders
Journal:  Prim Care Respir J       Date:  2007-04

Review 2.  The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions.

Authors:  Prasanthi Polamreddy; Nandu Gattu
Journal:  Drug Discov Today       Date:  2018-12-01       Impact factor: 7.851

3.  Drug Repurposing from an Academic Perspective.

Authors:  Tudor I Oprea; Julie E Bauman; Cristian G Bologa; Tione Buranda; Alexandre Chigaev; Bruce S Edwards; Jonathan W Jarvik; Hattie D Gresham; Mark K Haynes; Brian Hjelle; Robert Hromas; Laurie Hudson; Debra A Mackenzie; Carolyn Y Muller; John C Reed; Peter C Simons; Yelena Smagley; Juan Strouse; Zurab Surviladze; Todd Thompson; Oleg Ursu; Anna Waller; Angela Wandinger-Ness; Stuart S Winter; Yang Wu; Susan M Young; Richard S Larson; Cheryl Willman; Larry A Sklar
Journal:  Drug Discov Today Ther Strateg       Date:  2011

4.  The global burden of respiratory disease.

Authors:  Thomas Ferkol; Dean Schraufnagel
Journal:  Ann Am Thorac Soc       Date:  2014-03

Review 5.  A bibliometric review of drug repurposing.

Authors:  Nancy C Baker; Sean Ekins; Antony J Williams; Alexander Tropsha
Journal:  Drug Discov Today       Date:  2018-01-09       Impact factor: 7.851

Review 6.  Phytoconstituent based dry powder inhalers as biomedicine for the management of pulmonary diseases.

Authors:  Piyush Mehta; C Bothiraja; Kakasaheb Mahadik; Shivajirao Kadam; Atmaram Pawar
Journal:  Biomed Pharmacother       Date:  2018-09-24       Impact factor: 6.529

Review 7.  The potential to treat lung cancer via inhalation of repurposed drugs.

Authors:  Wing-Hin Lee; Ching-Yee Loo; Maliheh Ghadiri; Chean-Ring Leong; Paul M Young; Daniela Traini
Journal:  Adv Drug Deliv Rev       Date:  2018-09-04       Impact factor: 15.470

Review 8.  Drug repurposing: progress, challenges and recommendations.

Authors:  Sudeep Pushpakom; Francesco Iorio; Patrick A Eyers; K Jane Escott; Shirley Hopper; Andrew Wells; Andrew Doig; Tim Guilliams; Joanna Latimer; Christine McNamee; Alan Norris; Philippe Sanseau; David Cavalla; Munir Pirmohamed
Journal:  Nat Rev Drug Discov       Date:  2018-10-12       Impact factor: 84.694

9.  The Drug Repurposing Hub: a next-generation drug library and information resource.

Authors:  Steven M Corsello; Joshua A Bittker; Zihan Liu; Joshua Gould; Patrick McCarren; Jodi E Hirschman; Stephen E Johnston; Anita Vrcic; Bang Wong; Mariya Khan; Jacob Asiedu; Rajiv Narayan; Christopher C Mader; Aravind Subramanian; Todd R Golub
Journal:  Nat Med       Date:  2017-04-07       Impact factor: 53.440

Review 10.  Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.

Authors:  Hossein A Ghofrani; Ian H Osterloh; Friedrich Grimminger
Journal:  Nat Rev Drug Discov       Date:  2006-08       Impact factor: 84.694

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  2 in total

Review 1.  Nanotechnology-Assisted Metered-Dose Inhalers (MDIs) for High-Performance Pulmonary Drug Delivery Applications.

Authors:  Raj Kumar; Piyush Mehta; Konathala Ravi Shankar; Manju A K Rajora; Yogendra Kumar Mishra; Ebrahim Mostafavi; Ajeet Kaushik
Journal:  Pharm Res       Date:  2022-05-12       Impact factor: 4.580

2.  Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product.

Authors:  Maged S Abdel-Kader; Prawez Alam; Gamal A Soliman; Ramadan Al-Shdefat; Obaid Afzal
Journal:  Sci Rep       Date:  2021-07-28       Impact factor: 4.379

  2 in total

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