Literature DB >> 30512937

Nitric Oxide Reductase Activity in Heme-Nonheme Binuclear Engineered Myoglobins through a One-Electron Reduction Cycle.

Sinan Sabuncu1, Julian H Reed2, Yi Lu2, Pierre Moënne-Loccoz1.   

Abstract

FeBMbs are structural and functional models of native bacterial nitric oxide reductases (NORs) generated through engineering of myoglobin. These biosynthetic models replicate the heme-nonheme diiron site of NORs and allow substitutions of metal centers and heme cofactors. Here, we provide evidence for multiple NOR turnover in monoformyl-heme-containing FeBMb1 proteins loaded with FeII, CoII, or ZnII metal ions at the FeB site (FeII/CoII/ZnII-FeBMb1(MF-heme)). FTIR detection of the ν(NNO) band of N2O at 2231 cm-1 provides a direct quantitative measurement of the product in solution. A maximum number of turnover is observed with FeII-FeBMb1(MF-heme), but the NOR activity is retained when the FeB site is loaded with ZnII. These data support the viability of a one-electron semireduced pathway for the reduction of NO at binuclear centers in reducing conditions.

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Year:  2018        PMID： 30512937      PMCID： PMC6470035          DOI： 10.1021/jacs.8b11037

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  39 in total

1.  The cytochrome cbb3 from Pseudomonas stutzeri displays nitric oxide reductase activity.

Authors:  E Forte; A Urbani; M Saraste; P Sarti; M Brunori; A Giuffrè
Journal:  Eur J Biochem       Date:  2001-12

Review 2.  Nitric oxide reductases of prokaryotes with emphasis on the respiratory, heme-copper oxidase type.

Authors:  Walter G Zumft
Journal:  J Inorg Biochem       Date:  2005-01       Impact factor: 4.155

Review 3.  Proton transfer in bacterial nitric oxide reductase.

Authors:  U Flock; J Reimann; P Adelroth
Journal:  Biochem Soc Trans       Date:  2006-02       Impact factor: 5.407

4.  Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus.

Authors:  Yushi Matsumoto; Takehiko Tosha; Andrei V Pisliakov; Tomoya Hino; Hiroshi Sugimoto; Shingo Nagano; Yuji Sugita; Yoshitsugu Shiro
Journal:  Nat Struct Mol Biol       Date:  2012-01-22       Impact factor: 15.369

Review 5.  The production and detoxification of a potent cytotoxin, nitric oxide, by pathogenic enteric bacteria.

Authors:  Anke Arkenberg; Sebastian Runkel; David J Richardson; Gary Rowley
Journal:  Biochem Soc Trans       Date:  2011-12       Impact factor: 5.407

6.  The Semireduced Mechanism for Nitric Oxide Reduction by Non-Heme Diiron Complexes: Modeling Flavodiiron Nitric Oxide Reductases.

Authors:  Corey J White; Amy L Speelman; Claudia Kupper; Serhiy Demeshko; Franc Meyer; James P Shanahan; E Ercan Alp; Michael Hu; Jiyong Zhao; Nicolai Lehnert
Journal:  J Am Chem Soc       Date:  2018-02-07       Impact factor: 15.419

7.  NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle.

Authors:  Hideyuki Kumita; Koji Matsuura; Tomoya Hino; Satoshi Takahashi; Hiroshi Hori; Yoshihiro Fukumori; Isao Morishima; Yoshitsugu Shiro
Journal:  J Biol Chem       Date:  2004-10-25       Impact factor: 5.157

8.  Effect of Outer-Sphere Side Chain Substitutions on the Fate of the trans Iron-Nitrosyl Dimer in Heme/Nonheme Engineered Myoglobins (Fe(B)Mbs): Insights into the Mechanism of Denitrifying NO Reductases.

Authors:  Hirotoshi Matsumura; Saumen Chakraborty; Julian Reed; Yi Lu; Pierre Moënne-Loccoz
Journal:  Biochemistry       Date:  2016-03-29       Impact factor: 3.162

9.  Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages.

Authors:  Tânia M Stevanin; Jay R Laver; Robert K Poole; James W B Moir; Robert C Read
Journal:  Microbes Infect       Date:  2007-04-11       Impact factor: 2.700

10.  The production of nitrous oxide by the heme/nonheme diiron center of engineered myoglobins (Fe(B)Mbs) proceeds through a trans-iron-nitrosyl dimer.

Authors:  Hirotoshi Matsumura; Takahiro Hayashi; Saumen Chakraborty; Yi Lu; Pierre Moënne-Loccoz
Journal:  J Am Chem Soc       Date:  2014-02-03       Impact factor: 15.419
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  5 in total

Review 1.  Biological and Bioinspired Inorganic N-N Bond-Forming Reactions.

Authors:  Christina Ferousi; Sean H Majer; Ida M DiMucci; Kyle M Lancaster
Journal:  Chem Rev       Date:  2020-02-28       Impact factor: 60.622

Review 2.  Not Limited to Iron: A Cobalt Heme-NO Model Facilitates N-N Coupling with External NO in the Presence of a Lewis Acid to Generate N2 O.

Authors:  Erwin G Abucayon; Rahul L Khade; Douglas R Powell; Yong Zhang; George B Richter-Addo
Journal:  Angew Chem Int Ed Engl       Date:  2019-10-31       Impact factor: 15.336

3.  Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors.

Authors:  Evan N Mirts; Ambika Bhagi-Damodaran; Yi Lu
Journal:  Acc Chem Res       Date:  2019-03-26       Impact factor: 22.384

4.  Copper(I) Complex Mediated Nitric Oxide Reductive Coupling: Ligand Hydrogen Bonding Derived Proton Transfer Promotes N2O(g) Release.

Authors:  Gayan B Wijeratne; Mayukh Bhadra; Maxime A Siegler; Kenneth D Karlin
Journal:  J Am Chem Soc       Date:  2019-10-29       Impact factor: 15.419

Review 5.  Molecular understanding of heteronuclear active sites in heme-copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling.

Authors:  Christopher J Reed; Quan N Lam; Evan N Mirts; Yi Lu
Journal:  Chem Soc Rev       Date:  2021-03-01       Impact factor: 54.564
  5 in total

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