Literature DB >> 3051045

Amnesic effect of the novel anticonvulsant MK-801.

M J Benvenga1, T C Spaulding.   

Abstract

MK-801, a reported N-methyl-D-aspartate (NMDA) antagonist with affinity for the phencyclidine (PCP) receptor, injected intravenously in mice before a training trial in a passive avoidance procedure, produced a similar amnesic effect to that produced by the standard amnesic agent scopolamine. Compared to vehicle-treated mice, each drug produced significant amnesia, yet the potency of MK-801 was 40 times that of scopolamine. This result with the MK-801 is consistent with previous reports that drugs which act at PCP recognition sites within the brain produce memory impairing effects in rodents.

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Year:  1988        PMID： 3051045     DOI： 10.1016/0091-3057(88)90445-5

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  15 in total

1.  Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon.

Authors:  Ming-Chong Ng; Chun-Po Hsu; Yao-Ju Wu; Shih-Yu Wu; Yi-Ling Yang; Kwok-Tung Lu
Journal:  Fish Physiol Biochem       Date:  2012-01-04       Impact factor: 2.794

2.  Learning abilities depend on NMDA-receptor density in hippocampus in adult rats.

Authors:  J Stecher; W E Müller; S Hoyer
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

3.  Effects of NMDA receptor antagonists and sigma ligands on the acquisition of conditioned fear in mice.

Authors:  D J Sanger; D Joly
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Spider toxin (JSTX-3) inhibits the memory retrieval of passive avoidance tests.

Authors:  T Himi; H Saito; T Nakajima
Journal:  J Neural Transm Gen Sect       Date:  1990

5.  Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat.

Authors:  I Q Whishaw; R N Auer
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  Cortical DNA methylation maintains remote memory.

Authors:  Courtney A Miller; Cristin F Gavin; Jason A White; R Ryley Parrish; Avinash Honasoge; Christopher R Yancey; Ivonne M Rivera; María D Rubio; Gavin Rumbaugh; J David Sweatt
Journal:  Nat Neurosci       Date:  2010-05-23       Impact factor: 24.884

7.  Behavioral effects of MK-801 in the rat.

Authors:  D F Wozniak; J W Olney; L Kettinger; M Price; J P Miller
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

8.  The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.

Authors:  L J Herberg; I C Rose
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

9.  Dextrorphan attenuates the behavioral consequences of ischemia and the biochemical consequences of anoxia: possible role of N-methyl-d-aspartate receptor antagonism and ATP replenishing action in its cerebroprotecting profile.

Authors:  N Himori; Y Tanaka; M Kurasawa; K Mishima; N Akaike; M Imai; K Ueno; T Matsukura; H Watanabe
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.

Authors:  R F Genovese; X C Lu
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
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